Ketamine add-on treatment for treatment-resistant bipolar depression
Part of Mental health clinical trials.
This study tests whether adding an oral ketamine capsule (called KET-AD) to your current depression medication can help if you have bipolar disorder and haven't improved with at least two other treatments. Ketamine is a medication being researched for depression because it may work differently than standard antidepressants.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18–65 years old and had your first major depressive episode before age 50
- You have bipolar disorder (any type) and are currently in a moderate-to-severe depressed episode without psychosis
- You have tried at least 2 guideline-recommended bipolar depression treatments without adequate improvement, documented in medical records
- You have been on a stable dose of your current bipolar depression medication for at least 6 weeks
- Your weight is proportional to your height (BMI 18–40), with normal or stable thyroid function
- You are willing to stop recreational drugs, attend all study visits, and use contraception if fertile
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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