Virus therapy and low-dose radiation for children with aggressive brain cancer
Part of Brain & nervous system, Cancer clinical trials.
This trial tests whether a special herpes virus (G207) combined with low-dose radiation can help children with high-grade brain tumors (gliomas). The virus is injected into the tumor to attack the cancer cells while radiation helps boost the effect.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must not be pregnant or breastfeeding and must agree to avoid pregnancy during the trial.
- Your tumor must be located in the brain (not in the cerebellum, brainstem, or spinal cord) and must not have spread to multiple lobes of the brain.
- You must not be receiving any other cancer treatments or investigational drugs at the same time.
- You must not be on a high dose of steroids (more than 2 mg of dexamethasone or 10 mg of prednisone daily).
- You must not be taking antiviral medications for herpes infections.
- You must be able and willing to attend all follow-up visits and tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing a virus called HSV G207, which is injected directly into the tumor, to treat children and young adults with a type of brain tumor in the cerebellum that has come back or not responded to standard treatments.
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