Ketoconazole effects on cortisol rhythms in mild adrenal hormone changes
Part of Hormones & metabolism clinical trials.
This study tests whether the drug ketoconazole can safely help regulate daily cortisol patterns in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands make too much cortisol. It will compare how patients with MACS and healthy volunteers respond to the medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have MACS (mild autonomous cortisol secretion) and are already in another study (protocol 19DK0066) – OR you are a healthy volunteer matched by age, sex, and body size
- You can pause certain medications for a short time before the study starts
- You are not pregnant, breastfeeding, or taking estrogen-based hormones
- You do not have severe medical problems like uncontrolled diabetes, anemia, or liver disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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