Clin2
NCT07653464Possibly a fitNot yet recruiting

Insulin effects on blood vessels in obesity

Obesity (BMI>30)Insulin Resistance

Part of Hormones & metabolism clinical trials.

This study looks at how insulin affects blood vessels in people with obesity compared to healthy weight adults. It may help understand why obesity increases heart disease risk.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
64 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must be between 18 and 65 years old.
  • If you have obesity, your body mass index (BMI) must be between 30 and 45, and you must have insulin resistance (a condition where your body doesn't use insulin well).
  • If you are a healthy weight, your BMI must be between 18 and 25, and you must not have insulin resistance.
  • You cannot have diabetes, polycystic ovary syndrome, heart disease, or nerve problems.
  • You cannot be pregnant, breastfeeding, a smoker, or taking weight-loss medications.
  • You must not have any metal implants that are not safe for MRI scans, and you must not be claustrophobic.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05933707Recruiting
Study tiny vesicles and how they affect insulin

This study looks at how very small particles in the body (“extracellular vesicles”) relate to insulin action and how the body handles sugar. It may help researchers understand why some people have better or worse insulin responses.

St Louis, Missouri
NCT07874945Not yet recruiting· Early Phase 1
Insulin effects on blood vessels in obesity

This study looks at how insulin affects blood vessels in people with obesity compared to healthy weight adults. It aims to understand early blood vessel changes that may lead to heart problems, which could help improve prevention and treatment.

NCT05165706Recruiting
Study of how obesity affects insulin resistance over time

This study follows adults over time to understand how weight and body chemistry relate to insulin resistance. It may help researchers learn why insulin resistance happens and what could prevent or improve it.

Stanford, California
NCT06487832Recruiting
Effect of diabetes drug on brain response to insulin

This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) changes how the brain responds to insulin in people with different body sizes. It may help understand if this drug can improve brain function related to insulin.

Tübingen
NCT05743868Recruiting
Study of how insulin resistance affects blood fats

This study looks at how differences in insulin resistance may change how the liver makes triglycerides (a type of blood fat). It may help researchers understand why some people have higher triglycerides and how to target them better.

Amsterdam
NCT07516509Recruiting
How muscle cells respond to blood sugar in different body types

This research study examines how muscle cells handle blood sugar differently depending on whether someone is lean or has obesity, and whether their body resists insulin. Researchers will take small muscle samples to understand the genetic differences, which may help develop better treatments for insulin resistance and metabolic health.

Orlando, Florida

Hear when a new Obesity (BMI>30) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.