Esmolol for septic shock with rapid heart rate
Treatments studied
Part of Infections clinical trials.
This trial tests a medication called esmolol (a short-acting beta-blocker) to see if it can improve blood flow in tiny blood vessels (microcirculation) and help stabilize blood pressure in people with septic shock who have a fast heart rate. The goal is to see if slowing the heart rate can improve organ function and recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 to 85 years old.
- You must have septic shock, meaning a severe infection causing low blood pressure that needs a medication called norepinephrine (a pressor) to keep your blood pressure up.
- Your heart rate must still be 95 beats per minute or higher despite fluids and other treatments.
- You must be on a continuous norepinephrine infusion for at least 6 hours before starting.
- Your doctor must confirm you have enough fluids in your body and that your heart is pumping well (not severely weakened).
- You must be able to have clear images taken of the blood vessels under your tongue.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medication called anisodamine to see if it can improve blood flow in tiny blood vessels under the tongue in people with septic shock. This might help their organs work better and make them recover faster.
This study tests whether adding a sedative called dexmedetomidine affects blood flow in tiny vessels under the tongue and overall circulation in patients with septic shock. It may help doctors choose better sedation to improve recovery.
This study tests whether a medicine called esmolol, which slows the heart rate, can help people with septic shock (a severe infection that causes very low blood pressure) when their heart is beating too fast. Doctors will use ultrasound to make sure it's safe before giving the medicine.
This trial tests whether a heart-rate–controlling medication can better manage a new fast heart rhythm that happens during sepsis shock. It may help reduce heart strain and improve safety compared with standard care.
This Phase 3 trial tests whether landiolol (a short-acting heart-rate–lowering medicine) can improve blood circulation in adults with septic shock whose heart rate is too fast. Doctors will also check that the medication is safe in this critical-care setting.
This trial tests whether giving a medicine called norepinephrine early and adjusting the dose quickly can help people with sepsis who have very low blood pressure. It is for adults who are diagnosed within the last 3 hours and who have not already received this medicine.
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