Preventing fluid buildup after severe brain bleed
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether a special medication given directly into the brain's fluid spaces can prevent fluid buildup (hydrocephalus) after a severe brain bleed. If you've had a severe aneurysm bleed with bleeding into the brain's cavities and already have a drain tube in place, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You had a brain bleed from a burst aneurysm, and it's severe (Hunt Hess grade IV or V).
- The bleed spread into the fluid spaces deep in your brain.
- You already have a drain tube placed in your brain as part of your standard care.
- You can join the study within about 24 hours of getting that drain tube.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 trial tests whether milrinone, a heart-acting medicine, can improve brain blood flow to help prevent delayed brain ischemia after a severe subarachnoid hemorrhage. It may help reduce later brain damage in people who are too ill or sedated for a normal neurologic exam early on.
This trial tests a method to actively flush (irrigate) and help remove an active brain bleed inside the brain. It may help some adults recover better by improving how the blood is cleared after bleeding starts.
This trial tests a special catheter system used to drain cerebrospinal fluid (the fluid around the brain and spinal cord) in adults with bleeding into the brain’s fluid spaces. It may help because doctors can use the catheter soon after the bleeding to manage fluid and pressure.
This trial tests a treatment called neuroendoscopic lavage—a way to wash out a severe brain bleed in newborns using a tiny camera. It may help prevent fluid buildup and brain damage. Doctors want to see if it works better than regular care for babies under one month old with this condition.
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