Pramipexole for anhedonic depression in bipolar disorder
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This study tests whether the drug pramipexole can help treat depression in people with bipolar disorder, especially when they have lost interest or pleasure in things. You must already be on a mood stabilizer and currently in a depressive episode to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have been diagnosed with bipolar I or II disorder by a doctor.
- You are currently having a depressive episode that has lasted at least 2 weeks (but less than 18 months).
- You have lost interest or pleasure in things (anhedonia) that bothers you a lot.
- You are already taking a mood stabilizer medication (like lithium, valproate, or an antipsychotic).
- If you are a woman who could become pregnant, you must use reliable birth control and have a negative pregnancy test.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether OSU6162 can improve depressive symptoms in adults with bipolar depression who are already taking a stable mood-stabilizing medicine. It also checks safety by closely monitoring mood, heart rhythm, and other health factors during the study.
This study tests if a medication called pramipexole can help people with anxiety or depression who also find it difficult to connect socially. It looks at whether the drug can improve your motivation for social interactions and help you feel more connected.
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
This study tests if pramipexole can help people whose OCD hasn't improved with standard treatments like SSRIs or certain antipsychotics. You might qualify if standard therapies haven't worked for you.
This trial tests an investigational drug called LB-102 for people with bipolar I disorder who are currently experiencing a major depressive episode without psychosis. It aims to see if the drug is safe and effective for treating depression symptoms.
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hear when a new Bipolar Disorder (BD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.