Collagenase injection for muscle stiffness after brain or spinal injury
Part of Bones, joints & muscles, Brain & nervous system clinical trials.
This trial tests an injection called collagenase to reduce muscle stiffness (spasticity) in people who had a stroke, brain injury, or spinal cord injury at least 6 months ago. The goal is to make movement easier and improve daily function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 6 months past a stroke, brain injury, or spinal cord injury and medically stable.
- You must have some muscle stiffness (a score of at least 1 on a standard stiffness test).
- You must not be allergic to collagenase (the study drug).
- You must not be currently changing medications for muscle tone (like baclofen).
- You must not have had botulinum toxin (Botox) injections in the target muscles within the last 4 months, or phenol injections within the last 9 months.
- You must not be pregnant, have bleeding disorders, or have connective tissue diseases like Ehlers-Danlos syndrome.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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