Collagenase injection for muscle stiffness after brain or spinal injury
Part of Bones, joints & muscles, Brain & nervous system clinical trials.
This early-phase trial tests if an injection called collagenase (XIAFLEX) can help reduce muscle stiffness caused by stroke, brain injury, or spinal cord injury. It may be an option for patients who have had their injury for at least 6 months and have significant spasticity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your stroke, brain injury, or spinal cord injury happened at least 6 months ago
- Your muscle stiffness is moderate or greater (measured by a standard scale)
- You are not allergic to XIAFLEX or collagenase
- You are not changing medications for muscle stiffness right now
- You have not had Botox injections in the target area in the last 4 months, or phenol injections in the last 9 months
- You do not have a bleeding disorder, are not taking blood thinners (except low-dose aspirin), and are not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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