Clinical trials
Brain (Nervous System) Cancers clinical trials
Below are recruiting brain (nervous system) cancers clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07326566RecruitingPhase 2
Silevertinib and chemo for a type of glioblastoma
This trial tests a new drug, silevertinib, combined with temozolomide (a chemotherapy) for people with a newly diagnosed glioblastoma that has certain genetic markers. It aims to see if this combination works better than standard treatment for tumors with these specific features.
Birmingham, AlabamaAges 18 years+ - NCT06026735Recruiting
Lung cancer with brain spread: a surgical study
This trial looks at people with non-small cell lung cancer that has spread to the brain or the membranes around the brain. It aims to learn more about patients who are already scheduled for brain surgery, such as removing a tumor or placing a drain.
TaipeiAges 20–90 - NCT07393074Recruiting
Liver cancer and nervous system study
This study looks at how the nervous system works in people with liver cancer (hepatocellular carcinoma) or liver scarring (cirrhosis) who need a liver biopsy. It aims to see if there is a link between the nervous system and liver tumors.
LyonAges 18 years+ - NCT07680439RecruitingPhase 2
CAR T cell therapy study for children with DIPG brain tumor
This trial tests a new CAR T cell therapy (BCB-276) for children and young adults with a type of brain tumor called DIPG. The therapy uses your own immune cells that are specially trained to attack the cancer.
Los Angeles, CaliforniaAges 1–26 - NCT03911388RecruitingPhase 1
HSV G207 for Children with Recurrent Cerebellar Brain Tumors
This trial is testing a virus called HSV G207, which is injected directly into the tumor, to treat children and young adults with a type of brain tumor in the cerebellum that has come back or not responded to standard treatments.
Birmingham, AlabamaAges 3–22 - NCT07416188RecruitingPhase 1/Phase 2
LMP744 drug for returning glioblastoma
This trial tests an experimental drug called LMP744 for people whose glioblastoma has come back. It aims to see if the drug can slow or stop tumor growth by targeting specific proteins in cancer cells.
Bethesda, MarylandAges 18–99 - NCT07717827Recruiting
Brain tumor surgery guided by brain wiring maps
This trial uses advanced brain scans to create a detailed map of your brain's wiring before surgery. This helps surgeons remove more tumor safely while protecting important areas that control movement, language, and vision.
Palermo, PAAges 18 years+ - NCT03328078RecruitingPhase 1/Phase 2
Emavusertib for recurrent brain lymphoma after prior treatment
This Phase 1/2 trial tests emavusertib (a targeted medicine) in adults with primary central nervous system lymphoma that has come back or not responded to treatment. It’s designed to find safe dosing and see how well the treatment can control the lymphoma in the brain/spinal fluid.
Phoenix, ArizonaAges 18 years+ - NCT04421560RecruitingPhase 1/Phase 2
Testing pembrolizumab, ibrutinib, and rituximab for PCNSL
This Phase 1/2 study tests how well a combination of pembrolizumab, ibrutinib, and rituximab treats primary CNS lymphoma that came back or didn’t respond after prior brain treatment. It may help shrink the lymphoma and control it in the brain and fluid around the brain.
Boston, MassachusettsAges 18 years+ - NCT07698899RecruitingPhase 1
Study of a new treatment for childhood brain and CNS cancers
This trial tests a radioactive drug (177Lu-DTPA-Omburtamab) given directly into the fluid around the brain for children and teens with certain brain cancers or cancers that have spread to the central nervous system. It aims to see if this treatment is safe and effective for tumors that have come back or not responded to other therapies.
Basking Ridge, New JerseyAges 3–22 - NCT05386108RecruitingPhase 1/Phase 2
Test abemaciclib plus elacestrant for breast cancer brain spread
This trial studies whether the combination of abemaciclib and elacestrant can slow or shrink ER-positive, HER2-negative breast cancer that has spread to the brain. It is designed for people whose cancer has progressed despite prior hormone (endocrine) treatment.
Fullerton, CaliforniaAges 18 years+ - NCT05681195RecruitingPhase 2
Zanubrutinib plus pemetrexed for recurrent brain lymphomas
This trial tests zanubrutinib (a targeted lymphoma medicine) together with pemetrexed (chemotherapy) for lymphoma that has come back or did not respond well in or around the brain. It may help shrink measurable lymphoma and improve control of disease after prior treatments.
Miami, FloridaAges 18 years+ - NCT05859659Recruiting
Hope HOPE study for glioma using pathology and MRI
This study looks at glioma (a type of brain tumor) and uses brain tissue testing, MRI scans, and related measurements to better understand the disease. You may benefit by being closely assessed with MRI and study follow-up, though it’s not necessarily testing a new medicine based on the listed criteria.
Beijing, Beijing MunicipalityAges 18–90 - NCT06303869Recruiting
Deep brain stimulation for speech after stroke
This study tests if deep brain stimulation (a small device implanted in the brain) can improve speech and arm movement after a stroke that affected the deeper parts of the brain. It is designed for people who have trouble speaking clearly (dysarthria) from their stroke.
Pittsburgh, PennsylvaniaAges 18–75 - NCT06649058RecruitingPhase 2
Study on combining drugs and radiation for brain metastases
This trial is for people with cancer that has spread to the brain (brain metastases). It tests a new approach where you start a systemic therapy (drugs that travel through your body) and later add focused radiation to the brain tumors, instead of treating them right away. The goal is to see if this sequence works well and avoids unnecessary side effects.
Houston, TexasAges 18 years+ - NCT06899516Recruiting
Brain tumors and pets: A study of needs and concerns
This study explores the relationship between people with brain tumors and their pets. It uses a questionnaire to better understand what concerns and needs you may have as a pet owner during your illness.
Saint-EtienneAges 18 years+ - NCT07126821Recruiting
Brain disease diagnosis study using vision and language
This trial tests a new computer model that combines brain MRI scans and clinical data to help diagnose brain diseases. It may help doctors make more accurate diagnoses.
Changsha, HunanAges Any age - NCT07137494RecruitingPhase 1
CAR T-cell therapy for CNS lymphoma
This trial tests a new type of CAR T-cell therapy (MB-CART19.1) for people with central nervous system lymphoma (CNSL) that has come back or not responded to treatment. It aims to see if this therapy can help treat the lymphoma in the brain or spinal fluid.
Basking Ridge, New JerseyAges 18 years+ - NCT07143045Recruiting
Zorifertinib for lung cancer that has spread to the brain
This trial tracks how well zorifertinib works as a first treatment for people with a specific type of advanced lung cancer that has spread to the brain or spinal cord lining. Participants may receive zorifertinib or another standard treatment, and researchers will monitor their response over time.
Hefei, AnhuiAges 18 years+ - NCT07162246RecruitingPhase 2
Radiosurgery for large brain tumors and metastases
This trial tests a special high-dose radiation treatment for people who have up to two large brain tumors (metastases) and possibly other smaller ones. The treatment aims to control the tumors while limiting radiation to healthy brain tissue.
Toronto, OntarioAges 18 years+ - NCT03270059RecruitingPhase 2
MRI with special contrast to study brain and other CNS problems
This trial tests whether two special MRI contrast medicines—gadolinium and ferumoxytol—can better diagnose problems in the brain or central nervous system. It may help doctors identify what’s causing symptoms or abnormal brain findings.
Portland, OregonAges 10 years+ - NCT07462507RecruitingPhase 2
Brain tumor inflammation study using a new imaging agent
This trial tests a new PET scan tracer to see inflammation in brain tumors that have not been treated with radiation. It may help doctors better understand and monitor these tumors.
St Louis, MissouriAges 18 years+ - NCT07503717Recruiting
Brain scan surveillance in HER2-positive metastatic breast cancer
This study tests whether regular brain scans (surveillance) help spot brain metastases early in people with HER2-positive breast cancer that has spread to other parts of the body. Participation involves being randomly assigned to either routine brain scans or no extra scans to see which approach is better.
BeaumontAges 18 years+ - NCT07539441RecruitingPhase 1/Phase 2
Mirdametinib for brain and nervous system tumors
This trial tests a drug called mirdametinib for people with specific types of brain tumors or neurohistiocytosis (a rare condition affecting the nervous system). The drug targets mutations that cause these conditions to grow.
Basking Ridge, New JerseyAges 18 years+
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Common questions
- Are there clinical trials for brain (nervous system) cancers?
- Yes. Clin2 currently lists 95 recruiting brain (nervous system) cancers studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain (nervous system) cancers trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain (nervous system) cancers trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.