Experimental oral drug plus chemotherapy for pediatric brain cancer
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests an experimental oral drug (NLG802) combined with a standard chemotherapy called temozolomide for children and young adults with brain or spinal tumors that have come back or not responded. The goal is to see if this combination is safe and can help fight the tumor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- The child must be between 5 and 21 years old (under 22).
- The brain or spinal tumor must have come back after treatment or not responded to treatment.
- The child must be able to swallow capsules (pills) whole.
- They need to be reasonably active (able to do most daily activities) and have a life expectancy of at least 3 months.
- Blood counts and organ function (liver, kidneys, heart) must be within acceptable levels.
- They must be willing to provide a tumor tissue sample and blood samples for research.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests a combination treatment (ibrutinib plus indoximod along with chemotherapy) for children with brain tumors that have come back or are hard to treat. It may help shrink active tumor or control the disease when standard treatments can’t cure it.
This study tests whether Tumor Treating Fields (a wearable electrical device placed on the scalp) combined with temozolomide can treat brainstem gliomas (tumors in key parts of the brainstem). It may help slow tumor growth and improve outcomes for adults who have already finished surgery/radiation or are otherwise ready for the next treatment step.
This trial tests a combination of antiangiogenic drugs (which block blood supply to tumors) for children with certain brain or spinal tumors that have returned or not responded to standard treatment. The goal is to see if this drug combo can shrink or slow the tumor.
This trial tests a combination of three chemotherapy drugs (irinotecan, temozolomide, and vincristine) in children and teens whose solid tumors have come back or stopped responding to standard treatment. The goal is to see if this combination can help shrink or control the tumors.
This trial tests a combination of chemotherapy drugs (topotecan given into the spine plus maintenance chemo) for children under 6 with high-risk embryonal brain tumors. The goal is to see if this approach can improve outcomes after initial treatment.
This study tests a new combination of medicines (temozolomide, anlotinib, and bemarituzumab) taken during radiation therapy for children with a type of brain tumor called diffuse midline glioma. The goal is to see if this approach can help improve outcomes compared to standard treatment.
Hear when a new Progressive Pediatric Brain Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.