Combined ablation and clip repair for leaky mitral valve with atrial fibrillation
Part of Heart & circulation clinical trials.
This trial tests a procedure that combines two treatments for people with atrial fibrillation and a leaky mitral valve that causes symptoms. The procedure aims to fix the valve leak and restore normal heart rhythm, which may improve quality of life and reduce symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your heart's pumping function is normal or near-normal (ejection fraction 50% or higher).
- You have severe mitral regurgitation (a leaky mitral valve) rated 3+ or 4+.
- You have atrial fibrillation that is not well controlled (fast heart rate) and medication has not been able to control it.
- You are willing to attend all follow-up visits as required by the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a clip repair device for a type of leaky mitral valve caused by heart failure or atrial fibrillation (not by other valve problems). It aims to improve symptoms like shortness of breath and fatigue.
This trial tests a treatment for people with atrial fibrillation who also have a leaky mitral valve. It aims to see if treating both conditions together can improve symptoms.
This study tests whether catheter ablation (a procedure to correct irregular heartbeats) helps people with atrial fibrillation who have already had a successful MitraClip repair for a leaky mitral valve. It aims to see if the ablation improves heart rhythm and quality of life.
This study tests whether a catheter ablation procedure (a way to fix abnormal heart rhythms) can help people who have both constant atrial fibrillation and severe mitral regurgitation (a leaky heart valve). It is for people whose heart valve leak is caused by the rhythm problem, not by valve damage.
This trial tests a minimally invasive procedure (transcatheter edge-to-edge repair) to fix a leaky mitral valve caused by an enlarged atrium, not by heart muscle damage. It might be an option if your mitral regurgitation is related to atrial issues and your heart's pumping strength is normal.
This trial tests if catheter ablation—a procedure to fix heart rhythm—can help people with a leaky mitral valve that is caused by atrial fibrillation (functional mitral regurgitation). If you have persistent atrial fibrillation and moderate leaky valve, you may benefit from this treatment.
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