Metformin or zoledronate gel with minimally invasive surgery for gum disease in well-controlled diabetes
Part of Hormones & metabolism, Mouth & dental clinical trials.
This study tests whether applying a metformin or zoledronate gel during a minimally invasive gum surgery helps heal deep gum pockets and bone loss better than surgery alone. It's for people with type 2 diabetes that is well controlled (HbA1c under 7%).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have type 2 diabetes and your blood sugar is well controlled (HbA1c less than 7%).
- You have advanced gum disease (stage III or IV) with at least one deep pocket of 5 mm or more.
- You have a bone defect around a tooth that is at least 3 mm deep, confirmed by X-ray and a special 3D scan (CBCT).
- You are not a smoker.
- You are not pregnant or breastfeeding.
- You are not taking certain medications like bisphosphonates (for bone conditions) or other drugs that affect bone.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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