Bicarbonate dialysis for kidney failure patients

This trial tests whether taking sodium bicarbonate tablets by mouth can help correct low bicarbonate levels in people on hemodialysis, compared to using higher bicarbonate in the dialysis fluid. It aims to find a safer and more effective way to treat metabolic acidosis, a common condition in dialysis patients.

This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.

This trial tests if giving sodium bicarbonate helps critically ill patients who have both metabolic acidosis (too much acid in the blood) and acute kidney injury (sudden kidney trouble). It aims to see if this treatment can improve outcomes.

This trial tests whether adding an “alkali” treatment (to raise low blood bicarbonate) can improve blood vessel and kidney graft function in people whose kidney transplant is about 1 year old. It may help if you have lower-than-normal bicarbonate levels while on stable transplant and blood pressure medicines.

This study tests an oral medicine called Veverimer to see if it safely corrects low bicarbonate levels (metabolic acidosis) in people with chronic kidney disease. It might help you feel better and protect your kidneys.

This trial studies whether using a dialysis fluid with a different bicarbonate level can help people with long-term kidney failure treated with regular hemodialysis. If you qualify, you may be assigned to receive a specific bicarbonate concentration during your dialysis sessions.