Brain stimulation for leg stiffness and pain in multiple sclerosis
Part of Bones, joints & muscles, Brain & nervous system, Immune system & allergy, Pain clinical trials.
This trial tests a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) to see if it can reduce leg spasticity (stiffness) and pain in people with multiple sclerosis. It uses magnetic pulses to stimulate the brain, and does not require surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of multiple sclerosis (MS) using the 2024 McDonald criteria.
- Your disability level is moderate, with an EDSS score between 2.5 and 6.0 (can walk without aid or with some assistance).
- You have significant stiffness (spasticity) in at least one muscle group of one leg, as measured by a doctor.
- You have leg pain of at least 4 out of 10 on a pain scale.
- Your MS medications have been stable for at least 3 months before joining.
- You do not have epilepsy, metal implants, or implanted electronic devices (like a pacemaker) that would make brain stimulation unsafe.
- You are not pregnant or breastfeeding, and you have not had an MS relapse in the last 30 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a noninvasive brain stimulation technique (rTMS) can help people with multiple sclerosis who have leg stiffness and weakness. You will receive daily sessions over two weeks to see if it improves walking and quality of life.
This study tests a non-invasive brain stimulation technique called tDCS, which uses a mild electrical current to improve thinking, balance, and movement in people with multiple sclerosis. It may help with daily functioning and quality of life.
This study tests if transcranial magnetic stimulation (TMS) can help reduce muscle stiffness (spasticity) and improve balance in people with multiple sclerosis. TMS uses magnetic pulses to stimulate parts of the brain.
This trial tests a non-invasive treatment that uses gentle electrical stimulation on the back of the neck to help improve hand and arm function for people with multiple sclerosis. It could help you regain some dexterity and control in daily tasks.
This trial tests a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) to see if it helps improve symptoms in people with multiple sclerosis (MS). It may offer a non-drug option to manage symptoms like fatigue, walking difficulties, or other issues.
This trial tests whether painless magnetic stimulation of the brain (non-surgical) can reduce long-lasting nerve pain after spinal cord injury. It may help people whose spinal cord injury-related pain has been present for at least six months.
Hear when a new Multiple sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.