Treating emotional numbness in depression
Part of Mental health clinical trials.
This study tests whether adding a medication called lumateperone to your current antidepressant helps with emotional numbness, such as feeling flat, detached, or not caring about things you used to enjoy. If you qualify, you'll receive the study drug or a placebo alongside your usual antidepressant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of major depressive disorder (depression).
- You feel emotionally numb or blunted—like you're not feeling emotions as strongly as you used to.
- You are currently taking an antidepressant but still have emotional symptoms.
- You are not taking other antipsychotic medications, certain other medicines, or cannabis.
- You do not have significant liver problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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