Preventive treatment for radiation-induced brain swelling in lung cancer
Part of Brain & nervous system, Cancer, Injuries & trauma, Lungs & breathing clinical trials.
This trial tests whether giving a drug called Endostar early can prevent or reduce brain swelling after radiation therapy for lung cancer that has spread to the brain. It compares early use to giving the drug only after swelling appears.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have non-small cell lung cancer (the most common type of lung cancer).
- You have between 1 and 15 brain metastases (tumors that spread to the brain) with a total volume under 15 mL, and the largest tumor is no bigger than 4 cm.
- You are either about to receive stereotactic radiosurgery (a precise form of radiation) and have significant swelling around the brain tumors, or you already have radiation-induced brain swelling or necrosis (tissue damage) after having this radiation.
- Your general health is reasonably good, with a Karnofsky score of 60 or higher, meaning you can care for yourself with some help.
- You have adequate bone marrow and organ function, such as enough white blood cells, platelets, and hemoglobin, and your liver and kidneys work well enough.
- If you are of childbearing age, you must have a negative pregnancy test and agree to use effective birth control during the study and for 6 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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