Stopping heart failure drugs after excellent response to cardiac resynchronization therapy
Part of Heart & circulation clinical trials.
This trial studies whether patients with non-ischemic cardiomyopathy who have responded extremely well to a special pacemaker (CRT) can safely stop their heart failure medications. It aims to see if their heart function stays stable without these drugs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You were diagnosed with a type of heart muscle disease that is not caused by clogged arteries (non-ischemic cardiomyopathy).
- You had a specific heart rhythm pattern called left bundle branch block (LBBB) from the start, when your heart's pumping was first found to be weak.
- You have a special pacemaker or defibrillator (CRT device) that has been pacing your heart more than 95% of the time, with a narrow paced beat (QRS < 140 ms).
- An echocardiogram done at least 6 months after getting your device shows your heart's pumping function is back to normal (ejection fraction of 50% or higher) and your heart chambers are not enlarged.
- You have not had any heart failure hospitalizations or urgent visits since getting your device, and you do not need a water pill (loop diuretic) for fluid buildup.
- You have no family history of this type of heart muscle disease in a first-degree relative, and you have no severe valve problems or a history of dangerous heart rhythms requiring ICD shocks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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