Semaglutide before and after weight-loss revision surgery
Part of Hormones & metabolism clinical trials.
This study tests whether taking semaglutide (a once-weekly injection that helps control appetite and blood sugar) before and after a second weight-loss surgery can help people who regained weight after an initial sleeve gastrectomy. The goal is to see if the medicine improves weight-loss outcomes compared to surgery alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a sleeve gastrectomy at least 2 years ago.
- You have regained at least 20% of the weight you originally lost after that surgery.
- Your current body mass index (BMI) is 35 or higher, or 30 or higher with an obesity-related condition like diabetes or high blood pressure.
- Your doctor has approved you for revision surgery to a gastric bypass.
- You have had an upper endoscopy and imaging tests to check your stomach.
- You have not used semaglutide or similar weight-loss injections in the last 6 months.
- You do not have certain stomach problems (like a leak, narrowing, or large hiatal hernia) that require surgery without delay.
- You are not pregnant, breastfeeding, or planning pregnancy during the study, and you use reliable birth control if you could become pregnant.
- You do not smoke currently, and you are not taking other weight-loss medications within the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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