Early versus delayed semaglutide after weight-loss surgery
Part of Hormones & metabolism clinical trials.
This study tests whether starting semaglutide (a weekly injection that helps with weight loss) soon after surgery works better than waiting to see if you need it. If you have not lost enough weight one year after your surgery, this trial may help you decide the best time to start this medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had either sleeve gastrectomy or gastric bypass surgery at least 12 months ago at one of the participating centers.
- You have lost less than 20% of your total weight since the surgery. If you lost less than 10%, you can join right away. If you lost 10% to less than 20%, you can join if your weight has been stable for at least 3 months or by 18 months after surgery.
- You have not used any GLP-1 weight-loss medications (like semaglutide, liraglutide, or tirzepatide) since your surgery.
- You have not had significant weight regain (more than 25% of the weight you lost) since your lowest weight.
- You are able to give yourself injections and agree to the study procedures, including an upper endoscopy (a scope to check your stomach).
- You are not pregnant or planning pregnancy during the study, do not have type 1 diabetes, a history of medullary thyroid cancer, pancreatitis, or untreated severe depression or active eating disorder.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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