Pacemaker tuning for heart failure with preserved pumping function
Part of Heart & circulation clinical trials.
This trial tests whether adjusting the lower rate of an already-implanted pacemaker can improve symptoms and exercise capacity in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff to fill properly.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have heart failure with preserved ejection fraction (HFpEF), meaning your heart's pumping ability is normal (at least 50%) but you have symptoms like shortness of breath or fatigue.
- You have symptoms that limit your activity (NYHA class II or III) despite taking the best available heart failure medications.
- You already have an FDA-approved pacemaker (like a cardiac resynchronization therapy device) that can be programmed to adjust the lower heart rate.
- You are willing to undergo tests such as exercise testing, echocardiography, blood pressure checks, and blood draws.
- You are not pregnant, breastfeeding, or planning to become pregnant during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
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This study tests a pacemaker-based therapy designed to improve heart failure symptoms in people who have a type of heart failure where the heart pumps normally but doesn't relax properly. If you're getting a pacemaker for another reason and have heart failure with preserved pumping function, this could be an option.
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