Tocilizumab for acute ischemic stroke after clot removal
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial studies whether giving an anti-inflammatory drug called tocilizumab after emergency clot removal improves recovery from a severe stroke caused by a blocked artery in the brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had a stroke caused by a blocked large artery in the front part of the brain and are scheduled for emergency clot removal within 12 hours of when symptoms started.
- You can provide informed consent, or a legal representative can do so for you.
- If you are a woman who can become pregnant, you must use a highly effective birth control method.
- You do not have active infections, cancer, blood disorders, or liver problems that would make the treatment unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving a medication called tirofiban directly into the artery (intra-arterially) after a successful clot removal can improve recovery after a stroke. Tirofiban helps prevent new clots from forming, which may reduce the chance of another stroke.
This trial tests adding the anti-clotting drug tirofiban to standard clot removal for people who have a stroke due to a narrowed artery in the brain. The goal is to see if this combination improves outcomes without raising bleeding risk.
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This trial tests whether giving tirofiban (a blood thinner) shortly after the standard clot-busting drug tenecteplase can improve recovery from a moderate stroke. It is for people who have had a stroke within the last few hours and do not have certain risk factors like irregular heart rhythm or recent bleeding.
This trial tests whether adding a second medicine (tirofiban) to standard clot-busting treatment can help people who are not improving after the first hour. It is for people with a moderate to severe stroke who are not candidates for a clot-removal procedure.
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