Clinical trials
Adult Congenital Heart Disease clinical trials
Below are recruiting adult congenital heart disease clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04848844Recruiting
Congenital heart disease transplant registry study for adults
This study collects and shares anonymous information about adults being considered for a heart transplant because of a congenital (from birth) heart problem or an inherited heart muscle condition. The goal is to better understand these patients and support research that may improve care.
HamburgAges 18 years+ - NCT05258981Recruiting
MRI and testing study linking genes and thinking in adults
This study looks at how patterns on brain MRI scans and genes relate to thinking and test performance in adults. It may help researchers better understand long-term brain and cognitive outcomes and how they differ between people with specific early-life heart conditions and healthy controls.
Boston, MassachusettsAges 24–35 - NCT06089902Recruiting
European registry for anomalous aortic origin of coronary arteries
This is a European registry for people with an anomalous origin of a coronary artery from the aorta (AAOCA). It will track how the condition is treated—whether with surgery or monitoring—to learn what works best.
Padova, PDAges Any age - NCT06260059RecruitingPhase 4
Jardiance for adults with congenital heart disease and reduced heart function
This study tests a medicine called Jardiance (an SGLT2 inhibitor) to see if it helps improve heart function in adults with congenital heart disease who have recently experienced a drop in their heart pumping ability. Participants will take the medication alongside standard heart failure treatments.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06371937Recruiting
Heart and blood vessel disease biobank study
This study creates a collection of skin cells (turned into stem cells in a lab) from people with various heart and blood vessel conditions. It aims to find new ways to understand and treat these diseases.
London, OntarioAges 18–80 - NCT05670132Recruiting
Heart and brain rehab for youth with congenital heart disease
This trial tests a combined heart and brain rehabilitation program for young people with moderate to complex congenital heart disease. The goal is to improve both heart health and thinking skills, such as memory and attention.
BrusselsAges 8–25 - NCT06723704Recruiting
Long-term outlook in adults with congenital heart disease
This study looks at how adults with congenital heart disease (a heart problem you were born with) do over time. By reviewing medical records, doctors hope to learn what affects long-term health and help improve care for patients like you.
Rome, RMAges 18 years+ - NCT06769529Recruiting
Study of adults with congenital heart disease
This study follows adults born with a heart condition to see how they do over time, whether they had surgery or not. It aims to learn more about their health journey.
BolognaAges 18 years+ - NCT06775639Recruiting
Can we skip a heart artery test before surgery?
This study looks at whether people with adult congenital heart disease can skip a pre-surgery artery test (coronary angiography) if they already had a CT scan. If you qualify, you might help doctors find safer, simpler ways to prepare for heart surgery.
BolognaAges 18 years+ - NCT06784440Recruiting
Finding noninvasive markers of graft injury after heart transplant
This study looks for noninvasive markers (like blood or urine tests) that can show if a heart transplant is being injured. It aims to make monitoring safer and easier for children and adults with congenital heart disease who have had a transplant.
BolognaAges Up to 44 years - NCT06932081Recruiting
Study of SGLT2i in adults with congenital heart disease
This trial is a registry that follows adults with congenital heart disease who have started taking an SGLT2 inhibitor medication. The goal is to learn how well this treatment works for this group of patients.
Baltimore, MarylandAges 18 years+ - NCT06952933Recruiting
Trauma and resilience in adults with congenital heart disease
This study surveys adults with congenital heart disease to understand how psychological trauma and resilience affect their health. You would complete online questionnaires about your experiences and coping.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06969924Recruiting
How CRT works for adults with congenital heart disease
This study looks at how well cardiac resynchronization therapy (CRT) works for adults who were born with a heart defect. Researchers will review medical records to see if the therapy helps improve heart function.
Leiden, South HollandAges 18 years+ - NCT02258724Recruiting
Adults with congenital heart disease in Swiss GUCH centers
This study is a national registry that collects health information from adults (age 18+) with congenital heart disease. It may help researchers better understand care and outcomes in people treated at specialized Swiss centers.
BaselAges 18 years+ - NCT07477197Recruiting
Heart Institute Biobank for Adult Congenital Heart Disease
This study collects blood and tissue samples and health information from adults with or at risk for congenital heart disease or related heart conditions. It aims to help researchers better understand these conditions and improve future treatments.
Cincinnati, OhioAges 16 years+ - NCT05865119Recruiting
Best treatment approach for a certain heart wall defect
This study looks at the best treatment plan for people with a specific type of hole in the heart wall that affects the right side of the heart. It may help doctors choose an approach based on how well it works for patients who need treatment.
BordeauxAges 12 years+ - NCT06469918Recruiting
Support community for congenital heart defects
This trial is for people affected by congenital heart defects. It offers a support community (Co-Op) to help you connect, share, and get resources.
Rochester, MinnesotaAges birth+ - NCT07356778RecruitingPhase 4
Study of sotatercept for Eisenmenger syndrome patients
This trial tests a new drug called sotatercept for people with Eisenmenger syndrome or a related heart defect that hasn't been repaired. It may help if current treatments aren't working well enough.
Fukuoka, Not Required For This CountryAges 18 years+ - NCT07559253Recruiting
Heart Care Transition Education Led by Nurses or Doctors
This study tests whether nurse-led or doctor-led education helps young people with congenital heart disease (a heart condition present from birth) transition from pediatric to adult care. The goal is to make this transition smoother and more accessible for all patients, including those with disabilities.
Madison, WisconsinAges 12–26 - NCT07758894Recruiting
Breathing without a breathing tube during heart transplant surgery
This study tests whether heart transplant surgery can be done while the patient is awake and breathing on their own, instead of using a breathing tube. If successful, it may lead to faster recovery and fewer complications.
Guangzhou, GuangdongAges 18 years+ - NCT06688396Recruiting
Finding early signs of dilated cardiomyopathy with AI and mobile screening
This trial uses a smartphone app to screen first-degree relatives of people with dilated cardiomyopathy (DCM) for early signs of the condition. It aims to detect heart muscle weakness before symptoms start, so that treatment can begin sooner.
Lancaster, PennsylvaniaAges 18 years+ - NCT07456085Enrolling by invitationPhase 3
Rivaroxaban vs warfarin for mechanical heart valves
This trial compares a newer blood thinner (rivaroxaban) to the standard one (warfarin) for people with mechanical heart valves who have had clots or bleeding while on warfarin, or who cannot easily monitor their INR levels. It aims to see if rivaroxaban is safer and more effective.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT07558109Recruiting
Digital Heart Ultrasound Study
This study tests a new digital method for analyzing heart ultrasound images. Researchers want to see if computer software can help doctors read heart scans more accurately and quickly.
Hong KongAges 18 years+ - NCT07192952RecruitingPhase 3
Long-term safety of finerenone in children and young adults with heart failure
This study tests the long-term safety of the drug finerenone when taken alongside standard heart failure treatments in children and young adults with weakened heart pumping function (left ventricular systolic dysfunction). It includes both children already in a related study and new infants under 6 months old.
Aurora, ColoradoAges Up to 18 years
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Common questions
- Are there clinical trials for adult congenital heart disease?
- Yes. Clin2 currently lists 29 recruiting adult congenital heart disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a adult congenital heart disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a adult congenital heart disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.