Clinical trials
Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 5,650 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04928508RecruitingPhase 1
Testing SHetA2 for advanced solid tumor cancers
This early-phase study tests SHetA2, a new treatment, in people whose solid tumor cancer has returned or grown despite other treatments. It’s designed to check safety and see whether the treatment can help shrink or control cancer.
Oklahoma City, OklahomaAges 18 years+ - NCT05477849RecruitingPhase 1
Study drug for people with advanced solid tumors
This Phase 1 trial tests the safety and early effects of VG2025 in people with advanced solid cancers that have stopped responding to standard treatments. It’s mainly looking for side effects and how the body processes the drug, and it may offer a new option when other treatments haven’t worked.
Hangzhou, ZhejiangAges 18–75 - NCT04423185RecruitingPhase 2
Precision medicine trial for rare advanced solid tumors
This study tests targeted drugs or immunotherapy based on the genetic features of your tumor. It may help people with rare, advanced cancers whose disease has progressed after standard treatment options.
BeijingAges 18 years+ - NCT04150640RecruitingPhase 2
Chemo drug combination for advanced stomach or esophagus cancer
This Phase 2 trial tests whether a combination of chemo drugs (oxaliplatin and liposomal irinotecan) plus trastuzumab works better for people with advanced stomach or esophagus adenocarcinoma that has specific tumor markers (HER2 and PDL1). It may help shrink tumors and improve control of the cancer in people who have not had prior treatment for advanced disease.
Madison, WisconsinAges 18 years+ - NCT02840019Recruiting
MRI scans during pregnancy to study baby and placenta development
This study uses advanced MRI pictures of the fetus (the baby) and placenta to better understand normal development and possible problems. You may qualify if you’re between 18 and 40 weeks pregnant and can have the MRI safely.
Boston, MassachusettsAges 18–45 - NCT04891510Recruiting
Compare fat grafting products in breast surgery
This trial compares three methods for moving your own fat into the breast during breast surgery. It may help improve how well fat grafting works and how surgeons choose the best method for you.
New York, New YorkAges 18 years+ - NCT05219955Recruiting
Study of caregiver stress and sleep in older adults
This study looks at how caregiver stress affects sleep problems—especially trouble getting going in the morning. If you are a caregiver for someone with dementia and have specific morning sleep/energy difficulties, you may be able to join and help researchers better understand what helps.
Pittsburgh, PennsylvaniaAges 55 years+ - NCT04793152Recruiting
Tested vancomycin dosing for serious MRSA using different lab targets
This trial compares two ways of dosing vancomycin (an antibiotic) for serious MRSA infections by using different blood test targets. The goal is to see if the newer approach works at least as well as the standard one, while keeping patients safe.
Hamilton, OntarioAges 18 years+ - NCT04685226RecruitingPhase 1/Phase 2
Testing ICP-723 for advanced solid tumors you can’t remove
This trial studies ICP-723 (a new medicine) in people with advanced cancers that cannot be removed with surgery, and in some primary brain (CNS) tumors. It’s an early-phase study (Phase 1/2) to see how the treatment works and how safe it is.
Hefei, AnhuiAges 12 years+ - NCT04219254RecruitingPhase 1/Phase 2
Testing BI-1206 with pembrolizumab for advanced solid cancers
This early-phase trial studies BI-1206 together with pembrolizumab to treat advanced solid tumors. It may be an option if your cancer has progressed after prior anti–PD-1/PD-L1 treatment (or, in some groups, if standard treatments aren’t suitable).
Los Angeles, CaliforniaAges 18 years+ - NCT04478006Recruiting
Translational research for childhood blood cancers
This study looks at childhood leukemia and related blood disorders. It may help researchers learn more about the diseases and how to improve treatments for children.
Hong Kong, HksarAges Up to 18 years - NCT04260165Recruiting
Wrist surgery options for certain wrist arthritis
This trial compares two types of wrist surgery for osteoarthritis in the wrist bones (SLAC/SNAC stage II–III). It may help you and your surgeon choose the procedure that best improves pain and wrist function for your specific wrist arthritis pattern.
HelsinkiAges 18–75 - NCT06816927RecruitingPhase 2
Immunotherapy trial for glioblastoma with nivolumab and relatlimab
This trial tests whether two immunotherapy drugs, nivolumab and relatlimab, can help treat glioblastoma (GBM), a type of brain tumor. It is for people newly diagnosed or who haven't had radiation or chemotherapy yet and are scheduled for surgery.
Durham, North CarolinaAges 18 years+ - NCT06962254RecruitingPhase 1
Imatinib and Trametinib for KRAS-mutated solid tumors
This trial tests a combination of two targeted drugs, imatinib and trametinib, for people with advanced solid tumors that have a specific KRAS mutation (G12X). It may be an option if standard treatments have stopped working or are not available.
Taichung, TaichungAges 20 years+ - NCT06262919Recruiting
Monitoring safety of Tafinlar/Mekinist for BRAF-positive tumors
This study tracks the safety of the combination therapy Tafinlar and Mekinist in people with advanced or returning solid tumors that have a BRAF mutation, except for colorectal cancer. It aims to make sure the treatment is safe in the real world.
Nagakute, Aichi-kenAges 6–99 - NCT06208410RecruitingPhase 1/Phase 2
JS105 plus other treatments for advanced solid tumors
This trial tests a new drug called JS105 combined with other anti-cancer therapies for people with certain advanced breast, ovarian, endometrial, or cervical cancers. It aims to find out if these combinations are safe and effective.
Zhengzhou, HenanAges 18–75 - NCT06205602RecruitingPhase 2
HIV treatment with antibodies for a cure in Africa
This study tests if giving antibodies along with standard HIV medications can help control the virus without daily pills. It may lead to a functional cure for people living with HIV.
GaboroneAges 18–60 - NCT06133062RecruitingPhase 2
Study of atezolizumab, bevacizumab, and proton therapy for advanced liver cancer
This trial tests a combination of two immunotherapy drugs (atezolizumab and bevacizumab) plus targeted proton radiation for liver cancer that cannot be removed by surgery. The goal is to see if this approach can shrink tumors and improve outcomes for people with intermediate or advanced stage liver cancer.
Taoyuan City, TaiwanAges 18 years+ - NCT05801237RecruitingPhase 1/Phase 2
Study of two drugs for advanced solid tumors
This Phase 1/2 study tests two investigational medicines (PE0116 and PE0105) in people with advanced solid cancers that have spread or cannot be removed by surgery. It may help shrink tumors or slow disease when standard treatments have not worked or are not tolerated.
ShanghaiAges 18–75 - NCT07128303RecruitingPhase 1
GS-5319 for adults with solid tumors lacking MTAP
This trial tests an investigational drug called GS-5319 in people with solid tumors that are missing a protein called MTAP. It is for those whose cancer has continued to grow after other treatments or who cannot have standard therapy.
Boston, MassachusettsAges 18 years+ - NCT05701150Recruiting
Connects advanced solid-tumor patients to tumor gene data
This trial builds a large database using your existing tumor genetic test results (DNA and/or RNA). It may help researchers better understand advanced cancers and use gene patterns to guide future care.
Freiburg im Breisgau, Baden-WurttembergAges 18 years+ - NCT06464198Recruiting
Radiation and chemo after surgery for salivary gland cancer
This study tests giving radiation and chemotherapy together after surgery for aggressive salivary gland cancers of the head and neck. It aims to see how well this standard treatment works in real-world settings.
ErlangenAges 18–99 - NCT07440511Recruiting
Spleen stiffness test for advanced liver scarring
This study tests a new way to measure liver scarring using a non-invasive ultrasound of the spleen (spleen stiffness measurement). It's for people with fatty liver disease (MASLD) who have advanced fibrosis (scarring) to see if this method can accurately detect the severity of liver damage.
RomeAges 18 years+ - NCT06907017Recruiting
CorWave left heart pump first-in-human study
This trial tests a new left ventricular assist device (LVAD) for people with advanced heart failure who are not responding to standard treatments and are eligible for a heart transplant. The pump helps the heart circulate blood.
Sydney, New South WalesAges 18–75
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Common questions
- Are there clinical trials for advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 5,650 recruiting advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Locally Advanced Non-Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.