Clinical trials
Alcohol Use Disorder clinical trials
Below are recruiting alcohol use disorder clinical trials, each written for real people, not researchers. We’re tracking 368 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05827159RecruitingPhase 3
Medications started in the ER for alcohol use disorder
This study tests whether starting certain medications in the emergency room can help people with moderate to severe alcohol use disorder reduce heavy drinking and withdrawal problems after they leave the ER. It compares outcomes for participants who receive the study medications soon after an ER visit.
New Haven, ConnecticutAges 18–80 - NCT06269627RecruitingPhase 4
Brain activity study for alcohol use treatment
This trial tests how the medication acamprosate affects brain activity in people with moderate to severe alcohol use disorder. It may help researchers understand how this treatment works.
Bethesda, MarylandAges 21–65 - NCT07451574Enrolling by invitation
Study of non-alcoholic drinks for alcohol treatment
This study tests whether providing non-alcoholic drinks helps people in treatment for alcohol use disorder. You must be enrolled in Ria Health and have at least two symptoms of alcohol use disorder.
Stanford, CaliforniaAges 21–89 - NCT07216872Recruiting
Deep TMS to reduce heavy drinking in alcohol use disorder
This trial tests a non-invasive brain stimulation device (Deep TMS) to help people with alcohol use disorder reduce or stop heavy drinking. It uses magnetic pulses to target brain areas linked to addiction.
Tuscaloosa, AlabamaAges 18–86 - NCT03667846RecruitingPhase 2
Biomarker-guided treatment for drinking and PTSD symptoms
This Phase 2 study tests whether blood/brain “biomarkers” can help choose a treatment plan for people who have alcohol use disorder and PTSD. The goal is to improve outcomes related to drinking and PTSD symptoms compared with a standard approach.
New York, New YorkAges 18–70 - NCT03827460RecruitingPhase 1
Study tests how men and women respond to alcohol abstinence
This Phase 1 study looks at sex differences in how the body and brain respond when people stop drinking alcohol for a short time. You may be asked to complete questionnaires and provide blood samples to measure changes during the abstinence period.
Indianapolis, IndianaAges 21–35 - NCT03845205Recruiting
Liver transplant timing study for alcohol-related liver disease
This study compares early versus standard liver transplant timing for people whose liver illness was caused by alcohol use. It looks at treatment outcomes to see which approach helps patients do better.
Baltimore, MarylandAges 18 years+ - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT04135846RecruitingPhase 2
Alpha-blocker medicine to help reduce alcohol drinking
This Phase 2 trial tests whether blocking certain body signals (alpha receptors) with a study medicine can help people with alcohol use disorder cut down or stop drinking. You may be able to join if you meet alcohol-use criteria and can safely take the study drug.
Providence, Rhode IslandAges 18 years+ - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04598399Recruiting
Mindfulness program for alcohol relapse prevention
This study compares two non-medication programs to help people with alcohol use disorder stay away from relapse. It tests whether mindfulness-based relapse prevention works better than relaxation meditation without a guide.
AngersAges 18 years+ - NCT04616781RecruitingPhase 2/Phase 3
Ketone drink study for alcohol use disorder brain function
This study tests whether a ketone-based treatment (a ketone ester) can change brain activity in people with alcohol use disorder who are not currently seeking treatment. You may also have brain scans, so the study is looking for safe MRI eligibility and certain health factors.
Philadelphia, PennsylvaniaAges 21–65 - NCT04770025RecruitingPhase 2
Brain stimulation with therapy for risky alcohol use
This study tests whether a non-invasive brain stimulation device can make standard psychotherapy work better for people who drink in a risky way. It’s designed for community participants who are not already in alcohol-use treatment.
Albuquerque, New MexicoAges 21–60 - NCT04773691Recruiting
High-frequency brain stimulation to help cut alcohol use
This trial tests whether high-frequency rTMS (a non-surgical brain stimulation) can reduce how much alcohol you drink. It targets people with alcohol use disorder who are not fully stopping, and who want to cut down after a past relapse or failed withdrawal attempt.
DijonAges 18 years+ - NCT04929288Recruiting
Study how hormones affect alcohol risk in men and women
This study looks at how brain activity and hormone-related factors may help explain differences in alcohol risk between men and women. It may help researchers understand why alcohol use differs by sex and how risk develops.
Columbus, OhioAges 21–26 - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT04998916Recruiting
Brain stimulation to reduce heavy drinking in alcohol use disorder
This trial tests a type of noninvasive brain stimulation to see if it can reduce drinking and related “wanting” to drink. It may help people with alcohol use disorder who are currently drinking heavily.
Charleston, South CarolinaAges 21–65 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT05042102RecruitingPhase 2
Donepezil plus brain training for alcohol use disorder
This Phase 2 study tests whether donepezil, along with structured cognitive (brain) training, can improve outcomes for people with alcohol use disorder. It will measure whether this combination helps after recent heavy drinking, while tracking safety over about 13 weeks.
West Haven, ConnecticutAges 18–80 - NCT05102942Recruiting
Online training to improve attention for alcohol use disorder
This study tests whether an online attention-focused training program can help people with alcohol use disorder better control their attention and urges. It may offer an extra tool alongside standard primary treatment.
Valby, Capital Region of DenmarkAges 18–75 - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05365347Recruiting
Program to reduce risky alcohol use in early psychosis
This study tests an intervention aimed at helping people with early psychosis who also drink in a risky way. It may help reduce problematic drinking during a critical early period of illness.
Halifax, Nova ScotiaAges 16–35
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Common questions
- Are there clinical trials for alcohol use disorder?
- Yes. Clin2 currently lists 368 recruiting alcohol use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a alcohol use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a alcohol use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.