Biologics clinical trials

Personalized treatment study for psoriasis and joint health

This study tests whether a personalized treatment plan can help people with psoriasis and psoriatic arthritis, and also looks at how these conditions affect the heart. The goal is to find better ways to treat you and protect your heart health.

3D printed mesh for breast reconstruction after mastectomy

This trial tests a new 3D printed biodegradable mesh used during breast reconstruction right after a mastectomy for breast cancer. It aims to see how well the mesh works for cosmetic results and safety.

Biologic and targeted therapy registry for arthritis patients

This registry is collecting information about people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis who are starting or needing biologic or targeted medicines. It may help researchers better understand how these treatments work in real life.

Severe obesity tissue study during surgery

This study collects small tissue samples during certain abdominal surgeries to better understand what drives severe obesity and related blood-sugar patterns. If you agree to the extra sampling, your information and samples may help researchers build a “biological atlas” that could guide future treatments.

Biology and outcome registry for acute leukemia patients

This is a research registry that collects information and lab/blood sample data to better understand what acute leukemia looks like biologically and how patients do over time. It may help future treatment decisions, but it does not describe testing a new drug.

Dietary supplement study on aging markers and body health

This study tests whether a dietary supplement containing humic and fulvic acids (natural compounds) can improve markers of biological aging, inflammation, and how your body handles toxins. Researchers will check blood samples to see if the supplement affects these markers over time.

Slowing aging through comprehensive health screening and interventions

This study helps healthy older adults understand their biological age—how old your body actually is—and tests personalized interventions to help you age more slowly and stay healthier longer. Researchers will perform detailed health assessments and then guide you through targeted treatments based on your individual aging profile.

Heart rate monitoring to predict biologic therapy response in IBD

This study tests whether a wearable heart rate monitor can help predict how well biologic medications work for people with Crohn's disease or ulcerative colitis. If you are starting infliximab or vedolizumab for the first time, you may be eligible.

Walking Pattern Study After Ankle Cartilage Repair Surgery

This trial will study how walking patterns change after a type of ankle surgery called microfracture with a scaffold, which helps repair a damaged area of bone and cartilage. It may help you if you have that specific defect and are planning this surgery.

Combination therapy for metastatic colorectal cancer with RAS mutation

This trial tests a new drug called XS-03 combined with standard chemotherapy and bevacizumab for people with metastatic colorectal cancer that has a specific genetic change called a RAS mutation. It aims to see if this combination is more effective than current treatments.

Biologic therapy for early psoriatic arthritis

This study looks at whether starting biologic treatments early, even before joint pain appears, can help people with psoriasis who have signs of joint inflammation on ultrasound. You may be eligible if you have moderate to severe psoriasis but no joint symptoms yet.

Study of a cooling cap to prevent hair loss from chemo

This trial tests a cooling cap (DA-020) to see if it can prevent hair loss during breast cancer chemotherapy. It may help you keep more of your hair while getting treatment.

Study of anifrolumab for lupus patients not yet on strong treatments

This trial tests if a new drug called anifrolumab can help treat lupus in people who haven't taken strong medications like biologics or immunosuppressants before. It looks at overall disease activity and the chance to reduce steroid use.

An Unblinded, Single Arm, Pilot Observational Study to Test the Safety, Tolerability, Immunogenicity and the Biological Effects of TRB-001 Vaccination in Individuals Who Have Previously Undergone aSyn Immunotherapy

Study immune system disorders and genetics using lab samples

This study aims to better understand primary immune disorders by collecting genetic and blood (and related) information. It may help researchers identify what causes these conditions and improve future testing and care.

Tirzepatide for hot flashes in postmenopausal women with obesity

This study tests whether tirzepatide, a weekly injection, can reduce hot flashes and slow biological aging in postmenopausal women with obesity. It may help if you are experiencing bothersome hot flashes and are willing to follow a diet and exercise plan.

Secukinumab for Ankylosing Spondylitis in Biologic-Free Patients

This study is looking at how well secukinumab works for people with ankylosing spondylitis in Korea who have never taken a biologic or JAK inhibitor before. It aims to understand if the drug helps control symptoms over a short period of time.

Gut germs and pain after kidney transplant

This study looks at whether the germs in your gut (microbiome) and certain chemicals in your blood affect pain after a kidney transplant. By joining, you may help doctors better understand and manage pain for future kidney transplant patients.

Amicidin-β for infected surgical or traumatic wounds

This trial tests a topical solution called Amicidin-β for people with infected surgical or traumatic wounds. It may help treat the infection without needing strong oral or IV antibiotics.

B019 for relapsed or refractory B-cell acute lymphoblastic leukemia

This trial tests a new treatment called B019 for people whose B-cell acute lymphoblastic leukemia has come back or not responded to standard therapy. The treatment targets specific proteins on the cancer cells to help your immune system fight the leukemia.

Registry study tracking side effects from radiation and medicines

This study follows people with cancer to better understand which treatments cause certain side effects when radiation is combined with targeted (molecular) medicines. Your participation may help doctors predict and manage side effects more safely in the future.

BIOMEDE 2.0 trial for DIPG and similar brainstem gliomas

This phase 3 study tests targeted treatments (ONC201 or everolimus) for children with DIPG or similar diffuse midline brain tumors, based on the tumor’s genetic markers. It aims to improve outcomes by matching treatment to the tumor biology and comparing approaches in a randomized way.

Study of EBV-positive T/NK-cell lymphoma and related diseases

This study collects medical information and blood samples from people with Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases to better understand how these conditions progress and respond to treatment. It includes a retrospective part (looking back at medical records) and a prospective part (following people forward in time).

Teprotumumab for active thyroid eye disease

This study tests a drug called teprotumumab for people with active thyroid eye disease. It is designed to help reduce eye bulging and other symptoms, and may be an option if you have not had strong treatments before.