Clinical trials
Bipolar I Disorder clinical trials
Below are recruiting bipolar i disorder clinical trials, each written for real people, not researchers. We’re tracking 183 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05157620Recruiting
Yoga and exercise program for veterans with severe mental illness
This trial tests an exercise and yoga-style wellness program to help veterans with severe mental health conditions feel and function better. It may help with symptoms and overall well-being, especially if your condition is currently stable.
Pittsburgh, PennsylvaniaAges 18–70 - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+ - NCT04946916Recruiting
Testing blood/brain marker levels and thinking problems in psychiatric illness
This study looks at neurofilament light (a brain/nerve injury marker) and how it relates to thinking and memory problems in people with certain psychiatric conditions. It may help researchers understand brain changes and cognitive impairment, which could guide better diagnosis in the future.
BronAges 45–80 - NCT01980147Recruiting
Skills for Wellness program for youth coping with mental health risks
This trial tests a structured skills program to help children and teens (ages 9–21) cope with early mental health warning signs such as anxiety, mood swings, or unusual thoughts. It may help participants build practical coping tools and well-being.
Halifax, Nova ScotiaAges 9–21 - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT07101107Recruiting
Understanding social and brain responses in bipolar depression
This study looks at how people with bipolar depression and healthy volunteers process social situations and how their bodies respond. It may help researchers find better ways to support people with bipolar disorder.
Innsbruck, TyrolAges 18–65 - NCT07026461RecruitingPhase 4
TMS for depression: comparing two brain stimulation methods
This trial compares two types of transcranial magnetic stimulation (TMS) to see which works better for people with depression. TMS uses magnetic pulses to stimulate brain areas involved in mood regulation.
ÖrebroAges 18 years+ - NCT07684911Recruiting
Long-term effects of TMS for depression
This study looks at how well the benefits of transcranial magnetic stimulation (TMS) last over time for people with depression that didn't get better with other treatments. It also uses brain scans to find markers that might predict who will keep doing well.
RennesAges 18 years+ - NCT05648591RecruitingPhase 4
Iloperidone study for teens with schizophrenia or bipolar I
This Phase 4 study checks how safe and well-tolerated iloperidone is when used in a typical, open-label way for teenagers. It may help doctors better understand side effects and safety in teens with schizophrenia or bipolar I disorder.
Dothan, AlabamaAges 12–17 - NCT04987229Enrolling by invitationPhase 3
Kid’s long-term safety follow-up for OLZ and SAM treatment
This study checks how safe a kid’s ongoing treatment is over a longer period. It is mainly for children who already finished a related study and may benefit from continuing the same medicines.
Dothan, AlabamaAges 10–17 - NCT07494305RecruitingPhase 2
Testing a new drug for bipolar depression
This trial tests an investigational drug called LB-102 for people with bipolar I disorder who are currently experiencing a major depressive episode without psychosis. It aims to see if the drug is safe and effective for treating depression symptoms.
Bentonville, ArkansasAges 18–65 - NCT04057378RecruitingPhase 4
Testing the best electrical settings for ECT for depression
This trial studies which electrical “pulse settings” work best during electroconvulsive therapy (ECT) for people with depression. It may help doctors personalize ECT so the treatment is safer and works as well as possible for you.
ÖrebroAges 18 years+ - NCT05958940Recruiting
Bright light therapy study for depression
This trial studies whether daily bright light therapy can reduce depressive symptoms. It’s for adults with depression (including some with bipolar depression), and you would fill out questionnaires and be screened for safety.
EindhovenAges 18–65 - NCT07085923Recruiting
Heart health study for people with mental illness
This study tests a program to improve heart health in people with schizophrenia or bipolar disorder who take antipsychotic medication or lithium and have a high body weight. The goal is to help reduce heart disease risk.
OsloAges 25–70
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Common questions
- Are there clinical trials for bipolar i disorder?
- Yes. Clin2 currently lists 183 recruiting bipolar i disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar i disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar i disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.