Clinical trials
Bipolar Disorder I or II clinical trials
Below are recruiting bipolar disorder i or ii clinical trials, each written for real people, not researchers. We’re tracking 2,377 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07172516RecruitingPhase 3
Study of azetukalner vs placebo for bipolar depression
This trial tests whether the study drug azetukalner can help reduce depression symptoms in people with bipolar I or II disorder who are currently having a depressive episode. You would be randomly assigned to receive either the drug or a placebo (inactive pill) to see which works better.
Tucson, ArizonaAges 18–74 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Little Rock, ArkansasAges 18–75 - NCT06696755RecruitingPhase 2
Study of icalcaprant for bipolar depression
This study tests an oral medication called icalcaprant for adults with bipolar I or II who are currently in a depressive episode. The goal is to see if it reduces symptoms and whether it's safe when taken alongside your usual mood stabilizer.
Huntsville, AlabamaAges 18–65 - NCT06920940Recruiting
Ketogenic diet for bipolar disorder in teens
This study tests whether a ketogenic diet (a very low-carb, high-fat diet) can help teens with bipolar disorder who are currently feeling depressed or have mixed symptoms. Participants will receive medical and dietitian support while trying the diet for up to 12 weeks.
Los Angeles, CaliforniaAges 12–21 - NCT05427123Recruiting
Study for kids and teens with bipolar or cyclothymic disorder
This trial is testing treatments for children and teens (ages 9–19) who have been diagnosed with bipolar disorder or cyclothymic disorder. It also requires regular participation from a caregiver so the team can track symptoms and response over time.
Los Angeles, CaliforniaAges 9–19 - NCT06804525Recruiting
Adapting a mental health survey in Hong Kong
This study adapts a mental health survey for Hong Kong adults. It is open to adults aged 25 and older who live in randomly selected households and can speak Chinese or English.
Hong KongAges 25 years+ - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT05025605RecruitingPhase 1
Study medicine for agitation in youth with bipolar or schizophrenia
This Phase 1 trial tests whether BXCL501 is safe and can help reduce agitation in children and teens who have bipolar disorder or schizophrenia. You may be considered if your agitation is significant during screening, but certain recent medication and health factors can make you ineligible.
Anaheim, CaliforniaAges 10–17 - NCT07213466RecruitingPhase 4
Personalized weight-loss medication for bipolar disorder
This study wants to see if a personalized approach with FDA-approved weight-loss medications can help people with bipolar disorder who are overweight or have obesity, while staying on their mood stabilizer treatment. It might be a good fit if you have bipolar disorder and struggle with your weight.
Rochester, MinnesotaAges 18–65 - NCT07622927Recruiting
Family conversations about bipolar disorder risk in youth
This study helps families talk about bipolar disorder when a parent or caregiver has it. Researchers are creating and testing a new tool to help young people understand their risk and recognize early warning signs, with the goal of getting help sooner if needed.
Dallas, TexasAges 7 years+ - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Phoenix, ArizonaAges 18–65 - NCT06184581RecruitingPhase 4
Lithium vs lamotrigine for bipolar II disorder
This trial compares lithium and lamotrigine to see which is better for treating bipolar II disorder. You could get one of these two medicines to help manage your mood swings.
CopenhagenAges 18–70 - NCT06560957Recruiting
Timed eating for bipolar depression study
This study tests if a timed eating schedule (eating within a set window each day) can help improve depression symptoms in people with bipolar disorder. The goal is to see if this eating pattern can stabilize mood and energy.
Ottawa, OntarioAges 18–55 - NCT06740890RecruitingPhase 4
Exercise and a new medication for schizophrenia or bipolar disorder
This study tests whether a combination of a daily medication (olanzapine-samidorphan) and a structured exercise program can help people with schizophrenia, schizoaffective disorder, or bipolar disorder improve their health and well-being.
New York, New YorkAges 18–65 - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Chandler, ArizonaAges 18–70 - NCT07221864Recruiting
Emotions and brain activity in bipolar disorder
This study uses brain scans to understand emotions in bipolar disorder. It compares people with bipolar who are currently depressed or in a mixed state to healthy volunteers, and involves up to two visits to the research center.
Tulsa, OklahomaAges 18–65 - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT06134349Recruiting
Bipolar Lithium Imaging Scan Study
This study uses MRI scans to look at how lithium affects the brain in people with bipolar disorder. It may help researchers understand why lithium works and how to use it better.
Leiden, South HollandAges 18 years+ - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06373016Recruiting
Ketone drink study for stable bipolar disorder
This study tests whether a ketone drink can change how the body uses energy in people with bipolar disorder. It may help understand new ways to manage the condition.
Belmont, MassachusettsAges 18–45
Hear when a new Bipolar Disorder I or II trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for bipolar disorder i or ii?
- Yes. Clin2 currently lists 2,377 recruiting bipolar disorder i or ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder i or ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder i or ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.