Clinical trials
Breast Cancer Invasive clinical trials
Below are recruiting breast cancer invasive clinical trials, each written for real people, not researchers. We’re tracking 717 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06650748Enrolling by invitationPhase 2
A study of hormone therapy with or without a targeted drug for breast cancer
This trial tests if adding a targeted drug (CDK4/6 inhibitor) to hormone therapy works better than hormone therapy alone for women with a certain type of breast cancer (HR+/HER2-). The study measures the activity of tumor cells (Ki-67) to help decide treatment.
BeijingAges 18–70 - NCT06637150RecruitingPhase 3
Dalpiciclib with hormone therapy for early breast cancer
This trial tests whether adding the drug dalpiciclib to standard hormone therapy improves outcomes for people with a certain type of early breast cancer (hormone receptor-positive, HER2-negative). It may help lower the risk of the cancer coming back.
ShanghaiAges 18–70 - NCT06606730RecruitingPhase 3
Personalized pembrolizumab after strong chemo response for early triple-negative breast cancer
This trial is for people with early triple-negative breast cancer who had a strong response to chemotherapy combined with pembrolizumab before surgery. It aims to find the best way to continue using pembrolizumab after surgery to reduce the risk of cancer coming back.
BrusselsAges 18 years+ - NCT05900206RecruitingPhase 2
Trastuzumab deruxtecan vs standard chemotherapy before breast surgery
This Phase 2 study compares trastuzumab deruxtecan to standard chemotherapy given before surgery for HER2-positive breast cancer. It aims to see which treatment works better to shrink the tumor and spread before the operation.
MalmöAges 18 years+ - NCT06533826RecruitingPhase 2
Testing two antibody drugs for HER2-low breast cancer
This trial tests two antibody-drug conjugates (Enhertu and Datroway) for breast cancer that is HER2-low or HER2-0. It aims to find the best treatment sequence for people whose cancer has stopped responding to prior therapy.
Birmingham, AlabamaAges 18 years+ - NCT06535893RecruitingPhase 2
Testing new treatments for early breast cancer
This trial tests new treatments for early breast cancer (stage II or III). It aims to find better therapies that can stop the cancer from coming back, and you may receive a promising new drug.
Nagoya, Aichi-kenAges 18–80 - NCT06517212RecruitingPhase 2
Tirzepatide for weight loss in MRD-positive early breast cancer
This study tests whether the weight-loss drug tirzepatide (Mounjaro) can help prevent breast cancer from coming back in people who are overweight and have a sign of leftover cancer cells in their blood (called MRD-positive). You must have already finished at least one year of hormone therapy for early-stage breast cancer.
Dallas, TexasAges 18 years+ - NCT06502691RecruitingPhase 1/Phase 2
New imaging test to measure PARP in metastatic breast cancer
This trial tests a new imaging scan called [18F]FTT PET that may show how much of a protein called PARP is in your tumors. This could help doctors decide if a PARP inhibitor (a type of targeted therapy) is right for you. You may be able to join if you have metastatic breast cancer and are already planning to take a PARP inhibitor.
Seattle, WashingtonAges 18 years+ - NCT06512558Recruiting
Using augmented reality for breast cancer surgery planning
This trial tests whether augmented reality can help doctors locate tumors that cannot be felt during breast cancer surgery. If you are having surgery for a non-palpable breast lesion and need an MRI, you may be able to join.
Clermont-FerrandAges 18–100 - NCT04138719RecruitingPhase 2
Test two chemotherapy combos before breast surgery for triple-negative cancer
This trial compares two different chemotherapy combinations given before surgery (neoadjuvant therapy) for people with triple-negative breast cancer. It looks to see which drug combination works better to control the cancer before and around the time of the operation.
Shijiazhuang, HebeiAges 18–70 - NCT06445738Recruiting
Can some women safely skip radiation after breast cancer surgery?
This trial is for women 50 and older with early-stage, hormone-positive or HER2-positive breast cancer. It tests whether it is safe to skip radiation therapy after a lumpectomy if an MRI before surgery shows the breast tissue looks a certain way.
San Francisco, CaliforniaAges 50 years+ - NCT06446882Recruiting
HER2DX test to guide treatment for early HER2+ breast cancer
This trial tests whether a new test (HER2DX) can help doctors choose the best treatment combination for HER2-positive breast cancer before surgery. It's for people whose cancer hasn't spread and who haven't started therapy yet.
GrazAges 18 years+ - NCT06441890RecruitingPhase 2
Personalized chemo before breast cancer surgery
This trial tests whether giving chemotherapy before surgery, guided by the genetic profile of your tumor, can improve outcomes for a specific type of HER2-positive breast cancer. It aims to tailor treatment to each person's cancer biology.
Chicago, IllinoisAges 18 years+ - NCT06375798Recruiting
Breast conservation with radiation during surgery for early breast cancer
This trial is for women aged 55 or older with very early-stage breast cancer (stage 0 or 1) who want to save their breast. It tests giving a single dose of radiation during the lumpectomy instead of weeks of daily radiation afterward.
Shijiazhuang, HebeiAges 55 years+ - NCT06439693RecruitingPhase 2
Sequential therapy for newly diagnosed HER2+ breast cancer that has spread
This trial tests a sequence of targeted therapies for people newly diagnosed with HER2-positive breast cancer that has spread to other parts of the body. The goal is to find a treatment plan that can potentially cure the cancer.
Boston, MassachusettsAges 18 years+ - NCT06361940RecruitingPhase 2
Short-term hormone therapy before breast cancer surgery
This trial is testing how well a short course of hormone-blocking pills (endocrine therapy) works before surgery in women with early-stage hormone receptor-positive HER2-negative breast cancer. The goal is to understand what makes some cancers resistant to these treatments.
Milwaukee, WisconsinAges 18 years+ - NCT06362616Recruiting
Pre-surgery partial breast radiation for recurrent breast cancer
This trial tests a shorter course of radiation to just part of the breast before surgery for women who have had breast cancer return in the same breast. It's for those who have already had radiation to that breast and have a specific type of cancer (ER+, HER2-).
AmsterdamAges 51 years+ - NCT04069884Recruiting
Avoid extra lymph-node radiation for certain node-positive breast cancers
This trial tests a way to decide whether you can safely receive less radiation to lymph nodes after surgery for breast cancer that has spread to nearby nodes. If you qualify as “low risk,” the goal is to reduce radiation exposure while keeping cancer control safe.
Guangzhou, GuangdongAges 18–70 - NCT05184582Recruiting
Exercise program during chemotherapy for breast cancer
This trial studies whether a structured exercise program during pre-surgery chemotherapy can be safely done and may help people feel and function better during treatment. You may join if you have invasive breast cancer and can commit to the exercise plan while on chemotherapy.
MelbourneAges 18–100 - NCT06327490RecruitingPhase 2
ICG-guided vs. traditional lymphatic drainage for breast cancer surgery
This trial compares a new imaging method (ICG) to the standard method for manual lymphatic drainage during breast cancer surgery. It aims to reduce swelling in the arm after lymph node removal.
Gainesville, FloridaAges 18–99 - NCT06328465Recruiting
MRI for early detection of breast cancer spread
This trial is testing a new way to use MRI scans to find breast cancer that has spread to other parts of the body early. It is for people who have had aggressive breast cancer (HER2 positive or triple negative) and finished treatment with surgery, but still have a higher risk of the cancer coming back.
MilanAges 18–75 - NCT06324240RecruitingPhase 1
Personalized vaccine plus immunotherapy for triple-negative breast cancer
This trial tests a personalized vaccine made from your tumor combined with immunotherapy drugs (pembrolizumab or ipilimumab) for triple-negative breast cancer. It aims to help your immune system recognize and attack cancer cells.
Atlanta, GeorgiaAges 18 years+ - NCT06300125Recruiting
Freezing small low-risk breast tumors without surgery
This trial tests cryoablation (freezing the tumor with a needle) as a way to treat small, low-risk breast cancers without surgery. It is for women 50 or older whose cancers are hormone-receptor-positive and haven't spread to lymph nodes.
MilanAges 50 years+ - NCT05760612RecruitingPhase 3
After breast cancer surgery, test neratinib plus trastuzumab
This trial studies whether adding neratinib to standard trastuzumab treatment after neoadjuvant (before-surgery) therapy lowers the risk of breast cancer coming back. It is for people whose breast cancer is hormone-receptor positive and HER2 positive, with residual cancer found after neoadjuvant treatment.
GuangzhouAges 18–70
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Common questions
- Are there clinical trials for breast cancer invasive?
- Yes. Clin2 currently lists 717 recruiting breast cancer invasive studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer invasive trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer invasive trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.