Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06992336RecruitingPhase 2
Circulating tumor DNA guided extra treatment for early triple-negative breast cancer
This trial tests whether using a blood test to detect leftover cancer DNA after initial treatment can help doctors decide if extra therapy is needed for people with early triple-negative breast cancer. It aims to improve outcomes for those with remaining disease after neoadjuvant therapy.
Guangzhou, GuangodngAges 18–70 - NCT07233863Recruiting
Lymphovenous bypass for preventing lymphedema in breast cancer
This trial tests a surgery (lymphovenous bypass) to prevent or slow down lymphedema (arm swelling) in breast cancer patients who have already had lymph nodes removed. It may help those with early-stage lymphedema who haven't tried physical therapy yet.
Jakarta, Jakarta Special Capital RegionAges 18 years+ - NCT07115043RecruitingPhase 1/Phase 2
Study of AZD6750 for advanced solid tumors
This trial tests a new drug called AZD6750 for people with advanced solid tumors that have not responded to standard treatments. It aims to see if the drug is safe and effective.
Grand Rapids, MichiganAges 18 years+ - NCT02570815RecruitingPhase 1
Fluorescent-guided robotic lung surgery for early lung cancer
This early-stage trial tests a robotic lung surgery that uses a special dye with near-infrared light to help the surgeon remove only the tumor area. If you have a small, early lung cancer, this approach may help improve accuracy while limiting how much lung is removed.
Hamilton, OntarioAges 18 years+ - NCT04356235Recruiting
Comparing immediate vs delayed breast implant reconstruction results
This study compares two timing options for rebuilding the breast with implants, looking at cosmetic results, quality of life, and patient satisfaction. It may help you understand which approach could fit you better and what to expect over follow-up time.
BudapestAges 18–65 - NCT06694181Recruiting
Safe and explainable AI for heart, sepsis, and breast cancer patients
This trial uses artificial intelligence (AI) to create prediction models for three groups: cardiology patients, sepsis patients, and breast cancer patients. It aims to make these models safe and easy to understand for doctors.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07467330RecruitingPhase 3
Breast cancer trial: Adding capecitabine to standard treatment
This trial tests if adding a chemotherapy drug called capecitabine to the combination of dalpiciclib and hormone therapy works better than dalpiciclib and hormone therapy alone for advanced breast cancer that is hormone receptor-positive and HER2-negative. It is for people who have not had these treatments before.
Fuzhou, FujianAges 18 years+ - NCT04151940Recruiting
PET/CT scan changes during chemo with immune therapy
This study looks at how PET/CT scan results change while you receive chemo plus an immune therapy (a PD-1/PD-L1 medicine) for stage IV lung cancer. The goal is to better understand what the scans mean during treatment, which may help guide care in the future.
Seattle, WashingtonAges 18 years+ - NCT04858009RecruitingPhase 2
Warm chemotherapy placed in the belly for pancreatic cancer spread
This Phase 2 study tests a treatment that warms chemotherapy and delivers it directly into the abdomen to treat pancreatic cancer that has spread to the lining of the belly (peritoneum). You may be eligible if you completed earlier chemotherapy and your body shows signs the cancer is responding, with limited spread in the abdomen.
Rochester, MinnesotaAges 18–80 - NCT07219147RecruitingPhase 1
Combination treatment for advanced prostate cancer
This trial tests a combination of two treatments for advanced prostate cancer that has stopped responding to hormone therapy. One treatment is a targeted radiation therapy (177Lu-PSMA-617) and the other is an immunotherapy (sipuleucel-T) that helps your immune system fight the cancer.
Duarte, CaliforniaAges 18 years+ - NCT06911606RecruitingPhase 2
Serplulimab with chemotherapy before surgery for limited-stage small cell lung cancer
This trial tests adding an immunotherapy drug called serplulimab to standard chemotherapy before surgery for limited-stage small cell lung cancer (LS-SCLC). The goal is to see if this combination helps shrink the tumor and improve outcomes for patients who have not received prior treatment.
Guangzhou, GuangdongAges 18–75 - NCT05319639RecruitingPhase 1/Phase 2
Irinotecan plus immunotherapy for stomach cancer
This Phase I/II trial tests how well irinotecan combined with tislelizumab (an immunotherapy) treats advanced stomach or gastroesophageal junction adenocarcinoma. It mainly looks at safety and the best way to use this combination, and may help shrink tumors or slow disease growth.
Fuzhou, FujianAges 18–75 - NCT05851053Recruiting
Study of heart function years after breast cancer treatment
This study checks how well your heart works long after breast cancer treatment. If you joined the earlier de BLOC-I study, you may be invited for follow-up to understand long-term heart effects.
GroningenAges Any age - NCT06245889RecruitingPhase 2
PET-Guided Therapy for Triple-Negative Breast Cancer
This trial tests whether a special PET scan can help guide the best combination of chemotherapy and immunotherapy before surgery for patients with triple-negative breast cancer. It aims to personalize treatment and improve outcomes.
Baltimore, MarylandAges 18 years+ - NCT05910294Recruiting
Preventing and improving sexual health in early breast cancer
This study looks at ways to prevent and treat sexual discomfort in people with hormone-receptor positive breast cancer. It targets women who are not having current vaginal dryness or pain related to lower estrogen, and may help protect sexual comfort during cancer-related hormone treatment.
Basking Ridge, New JerseyAges 18 years+ - NCT06214195RecruitingPhase 3
Shengmai San to prevent heart damage from breast cancer therapy
This trial tests if a traditional Chinese medicine called Shengmai San can protect the heart during chemotherapy and targeted therapy for HER2-positive breast cancer. Patients take the supplement alongside standard treatment to see if it reduces the risk of heart problems.
Hangzhou, ZhejiangAges 18 years+ - NCT05825482Recruiting
Testing different breast surgery margin samples with a guidance tool
This study compares two ways surgeons take “margin” samples (tissue from the edge of the tumor area) during breast-conserving surgery for early breast cancer. It uses a guidance device to help collect these samples and aims to see which approach better supports safe, effective treatment.
Akron, OhioAges 18 years+ - NCT07341867RecruitingPhase 1
Dose changes for cancer treatment in people with Duffy null
This trial tests if changing the dose of certain chemotherapy drugs can help people with a genetic trait called Duffy null avoid side effects like low white blood cell counts. It is for people with multiple myeloma or triple-negative breast cancer starting specific treatments.
Boston, MassachusettsAges 18 years+ - NCT05325632RecruitingPhase 2
HER2 breast cancer vaccine plus chemo and targeted antibodies
This Phase 2 study tests a personalized immune-therapy vaccine made from your immune cells, given with weekly paclitaxel and HER2-targeted antibodies (trastuzumab and pertuzumab). It aims to improve treatment outcomes for people with HER2-positive breast cancer before standard local treatment (like surgery and radiation).
Tampa, FloridaAges 18 years+ - NCT06069115Recruiting
How radiation affects lung function in breast cancer patients
This study looks at how radiation therapy for breast cancer may affect your lungs over time. Researchers will measure lung function and see if problems develop, so they can better understand and protect patients.
Novosibirsk, Novosibirsk OblastAges 18 years+ - NCT06789653Recruiting
Using age-related proteins in early breast cancer
This study is testing a new way to use proteins in your blood that change with age to better understand early-stage breast cancer. It may help doctors personalize your care.
Chapel Hill, North CarolinaAges 22–66 - NCT07187726Recruiting
Trial to predict arm swelling risk during breast cancer radiation
This trial checks if telling you about your personal risk of arm swelling (based on a computer prediction) helps prevent it. You'll wear a compression sleeve during radiation and be monitored closely.
ArrasAges 18 years+ - NCT06086132Recruiting
Preventing heart damage from cancer treatment
This trial tracks how cancer treatments affect the heart. It may help doctors find ways to prevent heart problems during your treatment.
BolognaAges 18 years+ - NCT06261918Recruiting
Breast cancer study: linking metabolism to tumor behavior
This study looks at how your metabolism (things like blood sugar and cholesterol) might be linked to tumor genes and growth in people with breast cancer. The goal is to find new ways to treat the disease based on your metabolic profile. You may be eligible if you have locally advanced breast cancer (Stage II–III) and are willing to share your medical records.
RomaAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,201 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.