Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06880029RecruitingPhase 1/Phase 2
Timing of chemo and immunotherapy for breast cancer
This trial is testing whether the time of day you receive chemotherapy and pembrolizumab (immunotherapy) affects how well they work against triple-negative breast cancer. It's for people who will get these treatments before surgery.
Vila Nova de Gaia, RegiãoAges 18–75 - NCT06955156RecruitingPhase 2
Trilaciclib with immunotherapy and chemo for early TNBC
This trial tests a new drug combination for people with locally advanced triple-negative breast cancer who haven't had treatment yet. The goal is to see if adding trilaciclib to standard chemo and immunotherapy works better before surgery.
BeijingAges 18–75 - NCT06995443Recruiting
Can light therapy help 'chemo brain' after breast cancer?
This study tests whether a special light therapy (photobiomodulation) can help improve the 'chemo brain' – memory and thinking problems – that some women experience after breast cancer chemotherapy. If you've had memory issues since chemo and finished treatment within the past year, you may be able to join.
ValenciennesAges Any age - NCT07066189Recruiting
Lifestyle, Exercise, and Nutrition for Triple-Negative Breast Cancer
This study tests whether a healthy lifestyle program (diet and exercise) can help improve the results of breast cancer treatment before surgery. It's for women with triple-negative breast cancer who are getting chemotherapy and immunotherapy.
New Haven, ConnecticutAges 18 years+ - NCT07070765Recruiting
Study on dapagliflozin to protect the heart during breast cancer chemo
This trial tests if a heart-protecting drug called dapagliflozin can help prevent heart damage in breast cancer patients receiving a type of chemotherapy called anthracycline. It may be an option if you have low to medium heart risk factors.
Aberdeen, AberdeenshireAges 18–70 - NCT07256119Recruiting
Can a supplement help ease radiation skin burns?
This study tests whether taking an antioxidant called alpha lipoic acid can reduce skin irritation caused by radiation therapy in women with early-stage breast cancer. If you qualify, you would receive the supplement during your radiation treatment to see if it helps protect your skin.
ZagazigAges 18–75 - NCT07283692RecruitingPhase 2
New drug combo for triple-negative breast cancer before surgery
This trial tests a new drug, serplulimab, combined with standard chemotherapy (paclitaxel and carboplatin) given before surgery for triple-negative breast cancer. The goal is to see if this combination can shrink tumors more effectively.
ShanghaiAges 18–70 - NCT07332975Recruiting
Blood test for tumor DNA in early triple-negative breast cancer
This study is for people with early-stage triple-negative breast cancer (TNBC) that has not been treated yet. Researchers want to see if tracking tumor DNA in your blood can help guide treatment decisions. You would receive standard chemotherapy and surgery, plus give blood samples.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07335081RecruitingPhase 2
ctDNA in HER2-positive early breast cancer before surgery
This trial is testing whether monitoring ctDNA (genetic material from the tumor in your blood) can help guide treatment for HER2-positive breast cancer before surgery. It is for people with early-stage (Stage II or III) disease who have not yet started treatment.
ShanghaiAges 18–70 - NCT07677839Recruiting
Study using ultrasound to look at normal lymph nodes before breast surgery
This study uses a special type of ultrasound (UHFUS) to take detailed images of your lymph nodes before and during breast cancer surgery. The goal is to better understand normal lymph node anatomy, which may help prevent lymphedema (swelling) after surgery.
Sacramento, CaliforniaAges 18 years+ - NCT07351487RecruitingPhase 2
Chemo plus immunotherapy and anti-angiogenic drug for TNBC before surgery
This trial tests whether adding sintilimab (an immunotherapy) and bevacizumab (a drug that blocks blood supply to tumors) to standard chemotherapy before surgery can improve outcomes for women with stage II or III triple-negative breast cancer. It may help your immune system fight the cancer more effectively.
HefeiAges 18–75 - NCT07362914RecruitingPhase 3
Steroid cream for hand-foot skin reactions from chemo
This trial tests whether a corticosteroid cream can prevent or reduce hand-foot skin reactions caused by liposomal doxorubicin (a type of chemotherapy) in breast cancer patients. If you are starting this chemo and are concerned about skin side effects, this study may offer a way to manage them.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07369505RecruitingPhase 1
A study of Sapu003 for advanced tumors sensitive to mTOR
This trial tests a new drug, Sapu003, in people with certain advanced cancers that may respond to mTOR-targeted therapy. It is looking at two groups: postmenopausal women with a type of breast cancer (HR+/HER2-), and adults with kidney, liver, neuroendocrine, or TSC-related tumors. The goal is to see if Sapu003 is safe and effective.
AdelaideAges 18 years+ - NCT07426809Recruiting
A study to improve lumpectomy surgery with real-time imaging
This study tests a new imaging tool that helps surgeons see cancer margins in real time during a lumpectomy, aiming to reduce the need for a second surgery. It is for women with early-stage breast cancer who are planning a lumpectomy.
Beaumont, DublinAges 18 years+ - NCT07447440Recruiting
Study on natural fats linked to obesity-related diseases
This trial explores how certain natural fats in the body might affect diseases linked to obesity, such as breast cancer. It aims to see if these fats can reduce inflammation and improve health.
Pamplona, NavarreAges Any age - NCT07474337Recruiting
Mindfulness breathing for breast cancer symptom control
This trial tests whether simple mindfulness breathing exercises can help manage symptoms in people who are starting chemotherapy for breast cancer. You will be asked to practice breathing exercises and report how you feel.
ElâzığAges 18 years+ - NCT07476170Recruiting
HR+/HER2- advanced breast cancer treatment patterns in China
This study looks at the real-world treatment patterns and outcomes for people with HR+/HER2- advanced breast cancer who started their first treatment in China between 2024 and 2027. It aims to understand what treatments are used and how well they work in everyday practice.
Bingjie, Beijing MunicipalityAges 18–99 - NCT07498855Recruiting
Testing deep inspiration breath-hold for breast radiation
This trial checks how well a breathing technique (deep inspiration breath-hold) works when you have radiation to the lymph nodes in your chest. It looks at whether holding your breath during treatment helps protect your heart and lungs.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07548762Recruiting
Skin-Sparing vs. Standard Mastectomy for Breast Cancer
This study compares two surgical approaches to remove breast cancer: one that preserves more of the skin (skin-sparing) versus a standard approach. The goal is to see which method results in fewer wound-healing problems after surgery.
Guangzhou, GuangdongAges 18–75 - NCT07151963Enrolling by invitation
Can brain stimulation reduce chemo nerve pain in breast cancer?
This study tests a gentle brain stimulation treatment (called theta burst) to see if it can reduce nerve pain caused by breast cancer chemotherapy. If you have ongoing tingling or burning in your hands or feet, this treatment aims to calm those symptoms without using more medication.
New Taipei CityAges 18–80 - NCT06652295Enrolling by invitation
Self-physiotherapy for lymphedema
This trial tests whether a self-guided physiotherapy program can help manage lymphedema (arm swelling) after breast cancer treatment. If you have had breast cancer-related lymphedema for a while and haven't had recent treatment for it, this study may offer a way to take control of your symptoms.
IzmirAges 18–65 - NCT05952453RecruitingPhase 2
New ovarian cancer treatment with chemo plus maintenance medicines
This Phase 2 trial tests giving chemotherapy before surgery, then continuing two medicines afterward (olaparib and pembrolizumab). It’s designed for people with newly diagnosed Stage III/IV ovarian, fallopian tube, or primary peritoneal cancer who may benefit from tighter control of the disease.
Birmingham, AlabamaAges 18 years+ - NCT05059444Recruiting
Blood test study to watch for cancer coming back
This study looks at whether blood tests can detect signs that cancer may return after curative-intent treatment. You would have blood drawn around your usual follow-up visits for up to 5 years, and your de-identified health data would be shared with study investigators.
Birmingham, AlabamaAges 18 years+ - NCT04606030Recruiting
Tested lymph surgery for breast-cancer–related arm swelling
This trial studies a specialized lymph surgery (called VLNT, moving lymph tissue) to treat swelling in an arm caused by breast cancer treatment. It may help reduce lymphedema that doesn’t fully improve with compression and elevation.
Chicago, IllinoisAges 18–75
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,194 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.