Clinical trials
Caffeine clinical trials
Below are recruiting caffeine clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06712667Recruiting
Coffee and intense exercise: a caffeine metabolism study
This study looks at how coffee affects people who do intense exercise, and how their bodies process caffeine. It may help understand if coffee can improve exercise performance or recovery.
Shenzhen, GuangdongAges 18–40 - NCT06855108RecruitingPhase 3
Caffeine for newborn brain injury after oxygen loss
This trial tests if giving caffeine to newborns who had low oxygen at birth can help protect their brains. It compares caffeine plus standard care to placebo plus standard care for moderate to severe hypoxic ischemic encephalopathy (HIE).
SaidpurAges Up to 6 hours - NCT07022496RecruitingPhase 4
Can oral caffeine help with acute migraine attacks?
This trial tests whether taking caffeine by mouth can reduce the severity of a migraine attack when it happens. It may offer a simple, at-home option for people with different types of migraine.
CairoAges 18–60 - NCT07262060RecruitingPhase 2
Preventing kidney problems in preterm babies with caffeine
This study tests whether giving caffeine to very premature babies can help protect their kidneys as they grow. We will use a special light monitor on the skin to check blood flow to the brain and kidneys.
Madison, WisconsinAges 12 hours–4 days - NCT07434752RecruitingPhase 4
Energy drink with caffeine and green tea for fat burning during exercise
This study tests whether an energy drink containing caffeine and green tea extract helps increase fat burning while you exercise. Researchers want to see if it can boost your metabolism during physical activity.
Southport, QueenslandAges 18–45 - NCT07570121RecruitingPhase 1
How Caffeine Moves Through Pregnancy and to the Baby
This study looks at how caffeine is absorbed and transferred to a baby during pregnancy in women at risk of early delivery. Researchers hope to understand safe caffeine use in this situation and potentially help prevent complications.
Indianapolis, IndianaAges 18 years+ - NCT07665723RecruitingPhase 1
Study of afimkibart and other medicines in ulcerative colitis
This study looks at how afimkibart affects the way your body processes certain other medicines. It is for people with moderate to severe ulcerative colitis and helps researchers understand how to use this treatment safely.
Chula Vista, CaliforniaAges 18–60 - NCT07710768RecruitingPhase 1
A study on how UBT251 affects certain drugs in people with extra weight
This study tests if a new medicine called UBT251 changes how the body processes caffeine, midazolam (a sedative), and warfarin (a blood thinner). It is for generally healthy adults with a Body Mass Index (BMI) between 27 and 40.
Cypress, CaliforniaAges 18–65 - NCT06942117Recruiting
Caffeine's effect on understanding speech in noise
This trial tests whether drinking caffeine helps young adults hear speech better in noisy places. If you have normal hearing, don't smoke, and don't have certain health issues, you might be able to join.
Istanbul, IstanbulAges 18–30 - NCT07339722RecruitingPhase 1
Study of LY4515100 in healthy volunteers
This trial tests a new oral medication in healthy volunteers to see how it moves through the body and how safe it is. Taking part helps researchers understand how the drug works before it's studied in people with a certain condition.
Dallas, TexasAges 18–65 - NCT05761756Recruiting
Study of oxygen side effects in otherwise healthy adults
This study looks at what happens in the body when oxygen levels are too high, to better understand the mechanism of oxygen toxicity. You may be eligible if you are a healthy, non-smoking adult without certain medical conditions.
Durham, North CarolinaAges 18–45 - NCT06345716RecruitingPhase 2
Pain relief for kidney stones at home after ER
This study tests whether combining paracetamol with either tramadol or caffeine works better than a placebo for pain from kidney stones when you leave the emergency room. It aims to find a simple, effective pain reliever to take home.
MonastirAges 18–99 - NCT06432504Recruiting
How coffee affects your energy use
This study looks at how coffee affects your body's energy use (metabolic rate). It may help researchers understand the effects of coffee on healthy adults.
Shenzhen, GuangdongAges 18–40 - NCT06533137Recruiting
How your mind can influence the placebo effect
This trial studies how your awareness and personal beliefs affect the placebo effect—a real improvement in symptoms from a treatment that has no active medicine. Researchers are looking at healthy people to understand how the mind and body interact, which could help improve future treatments.
MilanAges 18 years+ - NCT06748989Recruiting
Dietary supplement for memory and focus in postmenopausal women
This study tests whether a dietary supplement containing PQQ, GABA, caffeine, and B vitamins can improve thinking and memory in healthy women after menopause. Participation involves taking the supplement for a period and completing simple cognitive tests.
Debrecen, HBAges 18 years+ - NCT07024940Recruiting
Caffeine and pre-workout effects on exercise
This study tests how caffeine and a pre-workout supplement affect your exercise performance. You'll take either a placebo or the supplement and do short exercise tests to see if it helps you perform better.
St Louis, MissouriAges 18–35 - NCT07210099Recruiting
Olive Supplement and Fat Burning During Exercise
This study tests whether a supplement made from olives (OliPhenolia®) can help your body burn fat more efficiently during exercise. It may be a good fit if you're a healthy, active adult in the UK.
CambridgeAges 21 years+ - NCT07238465RecruitingPhase 3
Exploring nervous system function in Down syndrome
This trial studies how the nervous system works in people with Down syndrome. It may help understand differences in body functions and improve future care.
Aurora, ColoradoAges 18–50 - NCT07324941Recruiting
EEG and caffeine timing in premature infants
This study uses EEG brain scans to find the best time to stop caffeine treatment in premature babies. Caffeine is given to help with breathing, and the goal is to see if brain activity can guide when to safely stop it.
BursaAges Up to 1 month
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Common questions
- Are there clinical trials for caffeine?
- Yes. Clin2 currently lists 43 recruiting caffeine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a caffeine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a caffeine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.