Clinical trials
Cancer Cachexia clinical trials
Below are recruiting cancer cachexia clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04627376Recruiting
Program to help prevent cancer-related weight and muscle loss
This trial tests a “multimodal” program meant to help people with cancer avoid developing cachexia, a condition that causes unwanted weight and muscle loss. It may help you stay stronger and maintain weight if you are not yet in advanced or rapidly worsening stages.
LimassolAges 18 years+ - NCT06112964Recruiting
Brain and behavior changes in cancer-related weight loss
This study looks at changes in thinking, behavior, and brain structure that can happen when people with cancer lose weight and appetite (called cachexia). Researchers will use questionnaires and brain scans to understand these changes, which may help improve care for people with cancer.
CambridgeAges 18 years+ - NCT06868849RecruitingPhase 1/Phase 2
Study of JMT203 for Cancer-Related Weight Loss
This trial tests a new drug called JMT203 for people with cancer-related weight loss (cachexia). It aims to see if the drug can help prevent or reverse weight loss in patients with certain solid tumors who are also receiving or have recently completed anti-cancer therapy.
ZhejiangAges 18 years+ - NCT07033026RecruitingPhase 2
Study of NGM120 for weight loss in colorectal cancer
This study tests an experimental drug called NGM120 for people with colorectal cancer who are losing weight (a condition called cancer cachexia). It is a placebo-controlled trial, meaning some participants will receive the drug and some will receive a placebo, to see if the drug helps stop or reverse this weight loss.
Los Angeles, CaliforniaAges 18 years+ - NCT07072728RecruitingPhase 2
Psilocybin therapy for anxiety in cancer patients
This trial tests whether psilocybin (a psychedelic drug given with talk therapy) can help people with cancer who have adjustment disorder—a condition where a cancer diagnosis causes severe anxiety or stress. It focuses on reducing anxiety and improving emotional well-being.
Abbotsford, VictoriaAges 18–80 - NCT07237464RecruitingPhase 1
Safety study of GB18 injection in healthy adults
This early-phase trial tests a new injection called GB18 in healthy adults to see if it is safe and how the body processes it. It may help researchers understand how to treat conditions that involve the immune system.
Beijing, Beijing MunicipalityAges 18–55 - NCT07670286Recruiting
Spotting early warning signs of pancreatic cancer wasting
This study checks if advanced computer analysis of your tumor and body can predict severe weight loss and muscle wasting (cachexia) from pancreatic cancer. If you join, you may help doctors find earlier warning signs to improve treatment.
BeijingAges 18 years+ - NCT05606523Recruiting
Test gut bacteria treatment for weight loss in pancreatic cancer
This study looks at how changing the gut microbiome (gut bacteria) may help people with pancreatic cancer regain strength and slow or reverse cancer-related weight loss (cachexia). It also studies gut bacteria differences in people with pancreatic cancer who are losing weight versus those whose weight is stable, and in healthy volunteers.
GenevaAges 18 years+ - NCT07408505Recruiting
New appetite drug for weight loss in advanced pancreatic cancer
This trial tests a new form of a drug (nano-megestrol acetate) to help people with advanced pancreatic cancer who are losing weight and have poor appetite. It aims to see if it can improve cachexia, a condition of severe weight loss and muscle wasting.
JinanAges 18–75 - NCT04406662Recruiting
Study for people living with incurable cancer
This study enrolls adults with advanced, incurable cancer to better understand care and outcomes in everyday settings. It may help by guiding improvements for people receiving treatment for symptom relief (palliative care).
EdinburghAges 18 years+ - NCT06898255RecruitingPhase 1
GFS202A for advanced solid tumors with weight loss
This study tests a new drug called GFS202A for people with advanced solid tumors who are experiencing weight loss or have a low body mass index (cachexia). The goal is to see if the drug is safe and can help improve appetite and weight.
Guangzhou, GuangdongAges 18–80 - NCT07519837Recruiting
Understanding Cancer Wasting in Digestive Cancers
This study explores why certain cancers cause patients to lose weight and muscle (called cancer cachexia) and tests ways to reverse it. Researchers will study tissue samples from patients with cancers of the food pipe, liver, stomach, or bile ducts to understand what's happening at a cellular level.
Shenyang, LiaoningAges 18 years+ - NCT06780423Recruiting
Muscle changes in colorectal cancer cachexia
This study compares muscle changes in people with colorectal cancer who have experienced weight loss (cachexia), those with colorectal cancer without weight loss, and healthy volunteers. Participants will have their trunk and leg muscles examined to understand how cachexia affects the body.
Diepenbeek, LimburgAges 18 years+ - NCT07643558Recruiting
Fish oil and weight training for cancer patients' muscle health
This study tests whether taking fish oil supplements combined with progressive weight training exercises can help preserve or build muscle strength in cancer patients undergoing treatment. The goal is to help you maintain physical function and quality of life during cancer care.
Erlangen, BavariaAges 18 years+ - NCT05642819Recruiting
MRI before and after surgery for abdominal cancers
This study uses extra detailed MRI scans before and/or around planned abdominal surgery to help researchers understand changes in the body. It includes people having surgery for certain cancers and some people having surgery for non-cancer (benign) conditions.
EdinburghAges 18 years+ - NCT07249775Recruiting
Study of new drug FID-022 for pancreatic cancer
This trial tests a new study drug called FID-022 for people with pancreatic cancer. It is a first-in-human study, meaning it is the first time this drug is being tested in people, and researchers want to see if it is safe and how it works.
Tampa, FloridaAges 18 years+ - NCT04067167Recruiting
Exercise bands versus muscle stimulation for people with cancer
This trial compares two types of exercise—flexible resistance band training versus a type of muscle stimulation—to see which is safe and helpful during cancer treatment. It may help improve physical function while you’re receiving anti-cancer care.
ErlangenAges 18 years+ - NCT07519564RecruitingPhase 1
Study of GB18 Injection for Cancer-Related Weight Loss
This Phase 1 trial tests a new drug called GB18 to help cancer patients who have experienced significant weight loss and muscle wasting—a condition called cancer cachexia. The drug works by targeting a specific protein involved in weight loss, and researchers want to learn if it can help patients regain weight and strength while also being safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07231120RecruitingPhase 1
Testing SXRN injection for cancer-related weight loss
This trial tests a new injection called SXRN for people with advanced cancer who have lost weight and appetite (cancer cachexia). The goal is to see if it is safe and might help improve weight and appetite.
Beijing, Beijing MunicipalityAges 18–75 - NCT06940102Recruiting
A study on megestrol acetate for weight loss in advanced digestive cancer
This study tests a special form of megestrol acetate (a medicine that can help with appetite and weight gain) in people with advanced digestive system cancers who are about to start or are already taking a type of targeted therapy called a TKI. The goal is to see if it helps with cancer-related weight loss and wasting (cachexia).
Shenyang, LiaoningAges 18 years+ - NCT07112196RecruitingPhase 2/Phase 3
Visugromab for cancer-related weight loss
This trial tests a medicine called visugromab for people with advanced cancer who have also lost weight. It aims to help with that weight loss (cachexia) and potentially improve your quality of life.
Norwich, ConnecticutAges 18 years+ - NCT07338487RecruitingPhase 1
Nanocrystalline megestrol acetate with chemoradiation for advanced cervical cancer
This trial tests a newer form of megestrol acetate (a medication that can help with appetite and weight) given alongside standard chemotherapy and radiation for locally advanced cervical cancer that cannot be removed by surgery. The study aims to see if this combination is safe and effective.
Changsha, HunanAges 18 years+ - NCT05865535RecruitingPhase 1
Dose study of AV-380 for cancer-related weight loss
This Phase 1 trial tests a new drug (AV-380) in people with solid tumor cancer who are losing weight and muscle because of cancer. It mainly helps researchers find a safe dose and see how the body responds, and it may offer a new option for cancer-related cachexia.
Beverly Hills, CaliforniaAges 18 years+ - NCT05376592Recruiting
Study genes and weight loss in pancreatic cancer
This study looks at how a person’s genetic variations may relate to cancer-related weight loss (cachexia) in pancreatic cancer. It may help researchers better understand who is most at risk and guide future treatments.
Charlotte, North CarolinaAges 18 years+
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Common questions
- Are there clinical trials for cancer cachexia?
- Yes. Clin2 currently lists 39 recruiting cancer cachexia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer cachexia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer cachexia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.