Clinical trials
Cancer (With or Without Metastasis) clinical trials
Below are recruiting cancer (with or without metastasis) clinical trials, each written for real people, not researchers. We’re tracking 13,308 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05010681RecruitingPhase 2
Lenvatinib plus immunotherapy after prior liver cancer treatment
This Phase 2 trial tests lenvatinib combined with the immunotherapy drug sintilimab in people with advanced liver cancer who got worse after prior PD-1/PD-L1 treatment. It aims to slow cancer growth and improve outcomes after immune therapy hasn’t worked.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05010772RecruitingPhase 1
Maintenance treatment study for AML in remission
This Phase 1 trial tests whether continuing decitabine alone or with other targeted drugs can help prevent AML from coming back after you reach remission. It’s designed to study safety and how well these maintenance options work for people who are not immediately able to get a stem cell transplant.
Houston, TexasAges 18 years+ - NCT05011045Recruiting
Brain radiation study tracking thinking and memory changes
This study looks at how whole-brain radiation affects thinking, memory, and other brain function in people with blood cancers that involve the brain. It may help doctors understand what to expect and which supportive treatments or monitoring could be useful.
Houston, TexasAges 18 years+ - NCT05011487RecruitingPhase 2
Before-surgery osimertinib plus chemotherapy for EGFR lung cancer
This study tests whether giving osimertinib together with chemotherapy before surgery can shrink and control EGFR-mutant, stage III lung cancer so it can be fully removed. If it works, it may improve the chances that the cancer does not come back after surgery.
Guangzhou, GuangdongAges 18–75 - NCT05014464RecruitingPhase 2
Testing ALK-targeted pills for ALK-positive advanced squamous cancer
This Phase 2 study tests whether ALK-targeted drugs can shrink or control advanced squamous cell cancer that has spread. You may be eligible if your tumor has an ALK gene rearrangement and you have not had prior cancer medicines for this stage.
Changsha, HunanAges 18 years+ - NCT05019703RecruitingPhase 2
Atezolizumab plus cabozantinib for teen osteosarcoma
This trial studies a combination of two medicines—atezolizumab and cabozantinib—for teenagers and young adults with osteosarcoma that has come back or spread. It aims to slow or shrink the cancer and help control disease that can’t be fully removed with surgery.
Boston, MassachusettsAges 12 years+ - NCT05022446Recruiting
Survey study on how COVID-19 affected lung procedures
This study is a survey sent to U.S. lung doctors to understand how COVID-19 changed the way certain lung procedures are done. Your answers could help improve future care and planning during respiratory outbreaks.
Houston, TexasAges Any age - NCT05023434Recruiting
Brain stimulation study for hand strength in brain tumor patients
This study uses brain stimulation during surgery to see how it affects hand strength and hand function. It may help doctors understand which brain areas are important for hand movement in people with certain brain tumors.
Milwaukee, WisconsinAges 18–75 - NCT05023772Recruiting
Laser and targeted radiation for spine metastases
This trial tests a combination treatment that uses a laser and focused radiation to shrink tumors in the spine and help stabilize the area near the spinal cord. It’s meant for adults with certain types of solid cancers that have limited spread in the spine and who are not good candidates for surgery.
Detroit, MichiganAges 18 years+ - NCT05024162Recruiting
MRI and biopsy study of how prostate tumors grow
This study looks at whether special MRI details can help predict how invasive your prostate cancer tumor is. It combines MRI images with your biopsy results to see if MRI patterns can match how aggressive the cancer may be.
Halifax, Nova ScotiaAges Any age - NCT05024214RecruitingPhase 1/Phase 2
Test of envafolimab plus lenvatinib for advanced solid tumors
This trial studies whether combining envafolimab (an anti-immune cancer medicine) with lenvatinib (a targeted pill) can shrink or control advanced cancers that have stopped responding to standard care. It may help people whose tumors are not curable with usual treatments, by testing a new combo and finding safe doses.
Bengbu, AnhuiAges 18 years+ - NCT05025774Recruiting
Exercise program study for young heart, leukemia, and lung survivors
This study looks at how an exercise program affects fitness and lung function in young people who are survivors of certain conditions (heart transplant, leukemia, or lung disease from prematurity). The goal is to see whether exercise can improve breathing and overall physical function safely.
Minneapolis, MinnesotaAges 8–25 - NCT05026983RecruitingPhase 2
Targeted drugs for melanoma spread to the brain
This Phase 2 trial tests two targeted medicines (binimetinib and encorafenib) for melanoma that has spread to the brain. It focuses on people whose tumor has a specific BRAF V600 mutation and who have brain metastases that are progressing or need treatment.
Houston, TexasAges 18 years+ - NCT05025813RecruitingPhase 2
Pembrolizumab before surgery or radiation for high-risk skin SCC
This Phase 2 trial tests pembrolizumab (an immune therapy) given before surgery to see if it can help control high-risk invasive cutaneous squamous cell carcinoma. The goal is to improve outcomes by treating cancer earlier and then following with standard surgery and radiation if needed.
Camperdown, New South WalesAges 18 years+ - NCT05029063RecruitingPhase 3
Rivaroxaban to prevent clots in cancer patients with new catheters
This Phase 3 study tests whether the medicine rivaroxaban can prevent dangerous blood clots in people with cancer who have a central venous catheter placed recently. It may help reduce clot risk while your catheter is in place, but you must meet safety and bleeding-risk criteria.
Halifax, Nova ScotiaAges 18 years+ - NCT05030597Recruiting
PET scans targeting FAP for oral cancer and recurrence
This trial uses a special PET scan that targets a substance called FAP to better find oral squamous cell cancer and check for recurrence. It may help doctors see where cancer activity is and guide treatment planning, especially around surgery and (for some people) neoadjuvant therapy before surgery.
Wuhan, HubeiAges 18–70 - NCT05031910Recruiting
Virtual 3D guidance for head and neck cancer surgery
This study tests whether a virtual reality (3D computer) model of surgery can help surgeons improve how head and neck cancer operations are planned and done. You may benefit from more personalized surgical planning, if you’re eligible for standard surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05033301Recruiting
Nurse Ned Clinic support for prostate cancer survivors
This study tests a nurse-led clinic (“Nurse Ned Clinic”) to see how well it supports men after curative (potentially curative) prostate cancer treatment. It may help you manage follow-up care during survivorship if you are at low risk of cancer coming back.
Toronto, OntarioAges 18 years+ - NCT05033678Recruiting
Teledermoscopy and AI help review your skin spot images
This study tests a way for doctors to send clear images of your skin spot to be reviewed remotely using teledermoscopy (digital images of the skin). It may help speed up specialist input and improve how skin spots are assessed.
LundAges 15 years+ - NCT05033392RecruitingPhase 2
PD-1 therapy plus chemotherapy before stomach cancer surgery
This Phase 2 trial tests whether adding a PD-1 antibody (JS001/toripalimab) to chemotherapy before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction adenocarcinoma. It aims to help shrink the tumor and make surgery more effective.
Shenzhen, GuangdongAges 18–79 - NCT05037825Recruiting
Study gut microbes with immune therapy in several solid cancers
This trial looks at how the gut microbiome (the bacteria in your digestive system) relates to outcomes when you take standard immune “checkpoint” cancer medicines. If you’re eligible, they’ll collect stool samples while you receive treatment for certain cancers.
Elizabethtown, KentuckyAges 18 years+ - NCT05038358Recruiting
Study of immune and chemo resistance in colorectal tumors
This study looks at how the immune system around a colorectal tumor relates to resistance to chemotherapy. You may be able to join if you are having surgery soon for colorectal cancer and have not yet had chemotherapy before surgery.
GrenobleAges 18 years+ - NCT05039632RecruitingPhase 1/Phase 2
NBTXR3 plus radiation with anti-PD-1 for advanced lung or liver cancers
This study tests whether adding NBTXR3 (given into a tumor) and targeted radiation to anti–PD-1/PD-L1 immunotherapy can improve cancer control in advanced cancers that have spread to the lung and/or liver. Participants may be assigned to different radiation approaches to try to trigger tumor shrinkage in both treated and nearby or distant tumor areas.
Houston, TexasAges 18 years+ - NCT05040360RecruitingPhase 2
Chemotherapy after surgery for high-risk pancreatic NET tumors
This Phase 2 trial studies whether giving chemotherapy after surgery can lower cancer recurrence risk in people with high-risk pancreatic neuroendocrine tumors (NETs). It may help you by testing an added treatment after the tumor has been removed.
Anchorage, AlaskaAges 18 years+
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Common questions
- Are there clinical trials for cancer (with or without metastasis)?
- Yes. Clin2 currently lists 13,308 recruiting cancer (with or without metastasis) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer (with or without metastasis) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer (with or without metastasis) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Liver Metastasis Colon Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Colorectal Cancer Liver Metastasis
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Leptomeningeal Metastasis of Breast Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.