Clinical trials · Los Angeles, CA
Cancer clinical trials in Los Angeles
We’re tracking 1,000 recruiting cancer studies with a site in or near Los Angeles — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Los Angeles
- NCT04920032RecruitingPhase 1
Blood test–guided extra treatment for colon cancer recurrence risk
This Phase 1 study uses a blood test called ctDNA to decide whether and how to adjust treatment in people with colon cancer who still have a small amount of disease left after surgery. If your blood test remains positive, the trial aims to reduce recurrence risk by guiding treatment changes.
Orange, CaliforniaAges 18 years+ - NCT07062172Recruiting
Lung cancer screening for family members
This trial offers a low-dose chest CT scan to screen for lung cancer in family members of people with a specific genetic mutation driving their lung cancer. It aims to catch cancer early in those at higher risk.
Orange, CaliforniaAges 18–80 - NCT05524584RecruitingPhase 2
Anastrozole, fulvestrant, and abemaciclib for hormone-positive breast cancer
This trial tests whether combining three medicines can better control hormone-receptor–positive, HER2-negative metastatic breast cancer that cannot be cured with surgery or radiation. It may help shrink tumors and slow disease growth compared with standard hormone therapy approaches.
Orange, CaliforniaAges 18 years+ - NCT06136624RecruitingPhase 3
Comparing a new drug to standard hormone therapy for advanced prostate cancer
This trial tests a new pill, opevesostat, against other hormone treatments for men with metastatic castration-resistant prostate cancer that has progressed after previous therapies. It aims to see which approach works better.
Orange, CaliforniaAges 18 years+ - NCT06335667Recruiting
MRI vs. TURBT for muscle-invasive bladder cancer
This study compares two ways to check if bladder cancer has grown into the muscle layer: an MRI scan (mpMRI) versus a standard surgery called TURBT (where a small tool removes a sample of the tumor). The goal is to see if the MRI can be as accurate as the surgery, so future patients might avoid an extra procedure.
Orange, CaliforniaAges 18 years+ - NCT06244771RecruitingPhase 1/Phase 2
Testing FMC-376 for KRAS G12C mutated solid tumors
This study tests a new targeted pill called FMC-376 for people whose cancer has a specific KRAS G12C mutation. The goal is to see if it can shrink tumors or slow their growth when other treatments have stopped working.
Orange, CaliforniaAges 18 years+ - NCT06592638RecruitingPhase 1
ZG006 for small cell lung cancer
This trial tests a new drug called ZG006 for people with small cell lung cancer that has not responded to or can no longer tolerate standard treatments. The goal is to find the best dose and see if it can help shrink or control the cancer.
Orange, CaliforniaAges 18–75 - NCT07447050RecruitingPhase 2
Riluzole to Prevent Chemo-Related Cognitive Problems
This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.
Orange, CaliforniaAges 18 years+ - NCT06632977RecruitingPhase 2
Matching targeted treatments to your prostate cancer's genetics
This trial is testing whether matching your cancer's specific genetic changes to a targeted treatment can help control metastatic prostate cancer that has stopped responding to standard hormone therapy and chemotherapy. You may receive a drug, a radioactive treatment, or a combination based on your tumor's molecular profile.
Orange, CaliforniaAges 18 years+ - NCT07581080Recruiting
Biofield therapy to ease fatigue from cancer immunotherapy
This study tests whether Reiki—a hands-on healing practice—can help reduce severe tiredness in cancer patients receiving immunotherapy drugs. If it works, it could offer patients another way to manage fatigue alongside their cancer treatment.
Orange, CaliforniaAges 18 years+ - NCT06577441RecruitingPhase 2
Adding enasidenib to usual care for higher-risk MDS with IDH2 mutation
This trial tests whether adding enasidenib (a targeted pill) to the standard chemotherapy (cedazuridine-decitabine) works better than the chemotherapy alone for people with higher-risk myelodysplastic syndrome (MDS) whose cells have a specific change in the IDH2 gene.
Orange, CaliforniaAges 18 years+ - NCT05886049RecruitingPhase 1
Testing a menin drug with standard chemo for newly diagnosed AML
This early-phase study tests a menin inhibitor drug (SNDX-5613) combined with standard induction chemotherapy (daunorubicin plus cytarabine) in newly diagnosed AML with specific gene changes (NPM1 or FLT3 status, or MLL/KMT2A or NUP98). It may help patients whose AML has these genetic features respond better to intensive treatment.
Orange, CaliforniaAges 18–75 - NCT06219941RecruitingPhase 2
Studying AZD0901 for Claudin18.2-positive advanced solid tumors
This trial tests a new drug called AZD0901 for people with advanced solid tumors that have a specific protein on their surface. It aims to see if the drug can shrink or slow the growth of these tumors.
Orange, CaliforniaAges 18 years+ - NCT07064018RecruitingPhase 1/Phase 2
SPEDOX-6 for advanced solid tumors
This trial tests a new form of the chemotherapy drug doxorubicin, called SPEDOX-6, for people with certain advanced solid tumors that haven't responded to at least two prior treatments. The drug is designed to deliver doxorubicin directly to cancer cells while possibly reducing side effects.
Orange, CaliforniaAges 18 years+ - NCT05733689RecruitingPhase 1
Testing new pre-surgery treatment for stomach and esophagus cancer
This Phase 1 trial tests how well a tailored (response-adapted) chemotherapy plan works before surgery for stomach or gastroesophageal junction cancer. It aims to improve treatment planning while checking early safety.
Orange, CaliforniaAges 18 years+ - NCT07200830RecruitingPhase 3
Testing different schedules of a targeted radiation drug for advanced prostate cancer
This trial tests two different dosing schedules of a drug called Lutetium-177 PSMA RLT, which delivers radiation directly to prostate cancer cells. It is for men with advanced prostate cancer that has stopped responding to hormone therapy and has spread, who have not yet had chemotherapy for this stage of the disease.
Orange, CaliforniaAges 18 years+ - NCT06811116RecruitingPhase 1/Phase 2
Adding sapanisertib to cabozantinib for beta-catenin mutant liver cancer
This trial tests whether adding a new drug (sapanisertib) to the usual chemotherapy (cabozantinib) can help people with advanced liver cancer that has a specific genetic change (beta-catenin mutation). It is for patients who have already had at least one prior treatment and are looking for a new option.
Orange, CaliforniaAges 18 years+ - NCT06549088Enrolling by invitation
Lung cancer tissue imaging study using light
This study tests a new imaging technique that uses light to look at lung tissue removed during surgery. It may help doctors see cancer details more clearly without damaging the tissue.
Orange, CaliforniaAges 18 years+ - NCT07097142RecruitingPhase 3
Shorter radiation for bladder cancer with chemo
This trial tests if a shorter course of radiation therapy works as well as the usual longer course for people with bladder cancer who are also receiving standard chemotherapy. The goal is to see if shorter treatment can reduce side effects while still being effective.
Orange, CaliforniaAges 18 years+ - NCT05803382RecruitingPhase 1
Adding a new drug to capecitabine for metastatic colorectal cancer
This Phase 1 study tests a new anti-cancer drug (ZEN003694) added to the usual chemotherapy capecitabine. It is for adults with colorectal cancer (and possibly other cancers) that has spread or cannot be removed and has continued despite prior standard treatment.
Orange, CaliforniaAges 18 years+ - NCT06580002RecruitingPhase 2
Can Riluzole Help with Chemo Brain? A Pilot Study
This study tests if a medicine called riluzole (currently used for ALS) can help with 'chemo brain' – memory and thinking problems after cancer treatment. It is for people who feel their mental sharpness has declined after breast cancer therapy, certain chemotherapies, or brain radiation.
Orange, CaliforniaAges 18 years+ - NCT04410302Recruiting
Personalized tumor research for bladder, lung, stomach, and liver cancers
This study uses a small sample of your tumor to grow it in the lab, which may help researchers understand your cancer better and find treatments that work for you.
Orange, CaliforniaAges 21–100 - NCT07000084RecruitingPhase 3
Testing gemcitabine with BCG for returning bladder cancer
This trial tests whether adding a chemotherapy drug called gemcitabine to the usual BCG therapy can help prevent bladder cancer from coming back again. If you have had BCG before and your cancer returned, this study might offer a more effective treatment option.
Orange, CaliforniaAges 18 years+ - NCT06520345RecruitingPhase 3
A new treatment for advanced prostate cancer that has stopped responding to hormone therapy
This trial tests a new radioactive drug (177Lu-TLX591) plus standard care against standard care alone for men with metastatic castration-resistant prostate cancer that has progressed on an androgen receptor pathway inhibitor. The goal is to see if this targeted radiation can help control the cancer.
Orange, CaliforniaAges 18 years+
Hear when a new Cancer trial opens near Los Angeles, CA
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Cancer trials in other cities
Where these studies are running near Los Angeles
Institutions with a site for the recruiting cancer studies listed above.
- University of California, Irvine Medical Center / UC Irvine Health · 19 studies
- UC Irvine Health · 8 studies
- University of California, Irvine (UCI) Health - UC Irvine Medical Center · 2 studies
- Chao Family Comprehensive Cancer Center
- City of Hope Orange County Lennar Foundation Cancer Center
- Kaiser Permanente Riverside Medical Center
- Research Site
- Zelgen Site 105
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in California.
Common questions
- Are there cancer clinical trials near Los Angeles?
- Yes. We're currently tracking 1,000 recruiting cancer studies with a site near Los Angeles, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Los Angeles?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Los Angeles to take part?
- Not necessarily. These studies have a site near Los Angeles, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Los Angeles regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.