Clinical trials
Cannabis clinical trials
Below are recruiting cannabis clinical trials, each written for real people, not researchers. We’re tracking 158 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07354412Enrolling by invitation
Can cannabis affect anesthesia and inflammation in spine surgery?
This study looks at how using cannabis before or during lumbar spine surgery might affect anesthesia and inflammation. It compares patients who have used cannabis to those who have not, to see if there are differences in pain, recovery, or side effects.
Columbia, MissouriAges 18 years+ - NCT05160688Enrolling by invitation
Study of brain and mood changes when stopping cannabis
This study looks at how thinking (cognition) and psychiatric symptoms (mood/mental health symptoms) change during a period without cannabis. It uses special matched twin pairs to compare changes after stopping.
Aurora, ColoradoAges 31–47 - NCT06457841Recruiting
Stress and Resilience in Afro-Descent Adults
This study looks at how stress and resilience affect people who use alcohol or cannabis to cope. It's for adults of Afro-descent who have used alcohol or cannabis at least a few times recently and are not in treatment for substance use.
Dallas, TexasAges 18–30 - NCT07594496Enrolling by invitation
Cannabis Withdrawal in Blood Cancer Patients During Stem Cell Transplant
This study looks at whether patients with blood cancers who use cannabis experience withdrawal symptoms when hospitalized for stem cell transplant or CAR-T therapy (a type of immunotherapy). Understanding these symptoms could help doctors better support patients during treatment.
Scottsdale, ArizonaAges 18 years+ - NCT05991882Recruiting
Mobile app study for young adults who use alcohol and marijuana
This trial tests a mobile app (phone-based) program for young adults who use both alcohol and marijuana. It aims to help you reduce risky use and improve your confidence in handling these substances.
Honolulu, HawaiiAges 18–30 - NCT06446479RecruitingPhase 2
THC's effect on alcohol use and brain reward
This study tests whether THC (the active ingredient in cannabis) can change how much alcohol you drink and how your brain responds to rewards. You will have MRI scans and take THC or a placebo, then drink alcohol in a controlled setting.
Aurora, ColoradoAges 21–40 - NCT07524985Recruiting
Cannabis Use Study: Understanding Effects in Daily Users
This study looks at how cannabis affects people who use it regularly in their daily lives. Researchers will use a smartphone app to track your experiences and better understand cannabis use in the general population.
Montreal, QuebecAges 18 years+ - NCT03972124RecruitingPhase 2
Cannabis to prevent migraine attacks before they start
This Phase 2 trial tests whether using cannabis can prevent migraine attacks from happening. It specifically looks at people with chronic migraine who have tried and not benefited from other prevention medicines.
Calgary, AlbertaAges 25 years+ - NCT07439471Recruiting
Study on tobacco and cannabis co-use in young adults
This study looks at why and how young adults use both tobacco and cannabis together. It may help understand patterns of use and improve future health programs.
Buffalo, New YorkAges 18–30 - NCT06699251Recruiting
Brief chat with your doctor about alcohol or cannabis for teens
This study tests whether a short, one-time conversation with a primary care provider can help teens who are at risk for alcohol or cannabis use. It's designed for young people ages 12–17 who get care at two specific health systems.
Commerce, CaliforniaAges 12–19 - NCT06430580RecruitingEarly Phase 1
Cannabinoids and stress response in heavy cannabis users
This early-phase study tests how cannabinoids affect your body's reaction to stress. If you use cannabis daily and have cannabis use disorder, you may be able to join to help researchers understand these effects better.
Tallahassee, FloridaAges 18–50 - NCT07339150Recruiting
App to reduce alcohol and marijuana use in college students
This trial tests a mobile app designed to help college students reduce their drinking and marijuana use. If you're a student who has had alcohol in the last 90 days, this may be a way to get support.
Charlotte, North CarolinaAges 18–26 - NCT07398443Recruiting
Study of marijuana and tobacco use in young adults
This study looks at how young adults use both marijuana and tobacco, and aims to understand their behaviors. It involves tasks and questionnaires, and may help develop better support for people who use both substances.
Providence, Rhode IslandAges 18–25 - NCT03332966Recruiting
Study of teens’ experiences in mental health care
This study looks at how young people experience mental health clinic care and how that relates to health outcomes. You may be invited if you are starting care in an adolescent mental health clinic.
HelsinkiAges 15–18 - NCT03995121Recruiting
Brain scan study using a PET tracer
This study tests how a special PET scan tracer behaves in your brain. It may help researchers better understand brain activity and improve imaging for future studies.
New Haven, ConnecticutAges 18–85 - NCT04704271RecruitingPhase 1
Study on THC effects in people with past cannabis use
This Phase 1 study looks at how THC (the main mind-altering ingredient in cannabis) affects healthy volunteers shortly after use. It focuses on differences between people and includes those who have used cannabis before.
West Haven, ConnecticutAges 18–55 - NCT04810858Recruiting
Study how chronic marijuana affects brain inflammation in HIV
This study looks at whether ongoing marijuana use changes “brain inflammation” and brain cell injury in people living with HIV. It may help researchers understand potential risks or protective effects and how treatment and brain health interact.
Winston-Salem, North CarolinaAges 25–59 - NCT04883255RecruitingEarly Phase 1
Study cannabis effects on brain function in adults with HIV
This early-phase study looks at how cannabis (and the body’s cannabinoid system) may affect thinking and brain-related measures in people with HIV. You may be asked to avoid cannabis and complete several brain and health assessments to see how these factors relate.
San Diego, CaliforniaAges 18–65 - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT05119244Recruiting
Study of environment factors in lung cancer
This study looks at how environmental factors may relate to lung cancer in adults. If you are between 18 and 59 and were treated for primary lung cancer at a participating hospital, you may be able to join.
Le Plessis-RobinsonAges 18–59 - NCT05337033RecruitingPhase 2
Testing cannabis for chronic headaches in teens
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
Vancouver, British ColumbiaAges 14–17 - NCT05351801RecruitingPhase 2
Test cannabis-based treatment for nerve pain
This Phase 2 study tests cannabis-derived products to see if they reduce neuropathic (nerve-related) pain in veterans. It may help people whose pain is persistent and causes significant daily impact, especially if certain exam tests show allodynia (pain from normally non-painful touch).
San Diego, CaliforniaAges 21 years+ - NCT05465538RecruitingPhase 1/Phase 2
PET imaging study using SV2A in older adults
This early-phase study tests a PET scan tracer called SV2A in adults age 50 and older. It aims to help researchers understand how the tracer works in the brain/body, which could support future diagnostic or treatment research.
New Haven, ConnecticutAges 50 years+ - NCT05514899RecruitingPhase 2
Cannabidiol and THC study for gut health and brain inflammation in HIV
This Phase 2 study tests whether cannabidiol (CBD) and tetrahydrocannabinol (THC) change the gut microbiome and brain-related inflammation in people with HIV. It may help researchers understand new ways to reduce inflammation, but you would need strict cannabis and CBD/THC avoidance during the study.
San Diego, CaliforniaAges 21–70
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Common questions
- Are there clinical trials for cannabis?
- Yes. Clin2 currently lists 158 recruiting cannabis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cannabis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cannabis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.