Clinical trials
Chronic Low Back Pain clinical trials
Below are recruiting chronic low back pain clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07211464Recruiting
ACT plus exercise for older adults with chronic low back pain
This study tests whether combining acceptance and commitment therapy (ACT) with exercise helps older adults manage ongoing low back pain. If you've had pain for at least 3 months and it's been bothering you, this approach might teach you new ways to cope and move better.
Hong KongAges 60 years+ - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT06859957RecruitingPhase 3
Melatonin for chronic low back pain
This trial tests if melatonin can help reduce chronic low back pain. If you have had low back pain for at least 3 months that limits your daily activities, this study might be for you.
RotterdamAges 18–65 - NCT06915896Recruiting
Chronic back or neck pain: predicting therapy outcomes
This study looks at people with long-term low back or neck pain who are waiting for physical therapy. It aims to find what factors predict how well they will do with different treatment paths.
Florence, FIAges 18 years+ - NCT07222462Recruiting
Radiofrequency ablation for chronic low back pain
This study tests if radiofrequency ablation, a procedure that uses heat to block pain signals from the facet joints in your spine, can help people with long-term low back pain that hasn't improved with other treatments like physical therapy.
Atlanta, GeorgiaAges 18 years+ - NCT06751160Recruiting
Dry needling vs. soft tissue massage for tight hamstrings
This study compares two treatments—dry needling and soft tissue massage—to see which works better for relieving tight hamstring muscles in people with low back pain.
Lahore, Punjab ProvinceAges 20–40 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85 - NCT06944730Recruiting
Trunk muscle training for better movement and balance in low back pain
This study tests whether trunk muscle training can improve the quality of your movements and balance if you have chronic low back pain. It is designed for people with moderate pain and no other major health issues.
Hong KongAges 18–55 - NCT06771713Recruiting
Brief Pain Reprocessing Therapy for Veterans with Chronic Back Pain
This trial tests a type of talk therapy called Brief Pain Reprocessing Therapy for Veterans with long-term low back pain. The therapy is done over video calls, so you can join from home. It aims to help retrain how your brain processes pain signals.
Ann Arbor, MichiganAges 18 years+ - NCT06940063Recruiting
Music therapy for chronic low back pain
This trial tests whether an active music-based program can help reduce chronic low back pain. It is for adults aged 18 to 65 whose pain has lasted at least 3 months and has been present on most days.
Denton, TexasAges 18–65 - NCT07470307Recruiting
Exercise for chronic low back pain: Pilates vs. strength training
This trial compares dynamic lumbar strengthening exercises to Pilates, both combined with myofascial release, for people with ongoing low back pain. It aims to find which approach works better for reducing pain and improving function.
Lahore, Punjab ProvinceAges 25–35 - NCT06888895Recruiting
Stretching for tight hamstrings in low back pain
This study compares two types of hamstring stretching techniques (passive vs. active-passive) to see which one improves flexibility more in people with chronic low back pain. It may help you if your hamstrings feel tight and your pain has lasted at least 3 months.
Cébazat, FranceAges 18–65 - NCT07058376Enrolling by invitation
Herbal medicine for chronic low back pain
This trial tests whether a herbal medicine strategy can safely and effectively reduce chronic low back pain lasting over 3 months. It may be an option if your pain has been moderate to severe and you are looking for alternative treatments.
Seoul, Gangnam-GuAges 19–69 - NCT06902233Recruiting
Brain stimulation for chronic low back pain
This trial tests if a non-invasive brain stimulation technique can help people with long-lasting low back pain. It uses mild electrical currents to adjust brain activity and may reduce pain and improve daily function.
Dunedin, OtagoAges 18–75 - NCT07681336Recruiting
Ear nerve stimulation for chronic low back pain
This trial tests if stimulating the vagus nerve through the ear can reduce chronic low back pain in people who haven't gotten enough relief from painkillers. It aims to see if this non-invasive treatment can help manage pain without medication.
Ghent, Oost-VlaanderenAges 30–60 - NCT06828016Recruiting
Foot Reflexology for Chronic Low Back Pain
This study tests whether foot reflexology—a gentle massage of the feet—can help relieve chronic low back pain that has lasted more than 12 weeks. It is a safe, non-drug approach that may be a good option for people looking for a natural way to manage their pain.
New Taipei CityAges 18–100 - NCT06821607Recruiting
Telerehab for chronic low back pain
This study tests if online rehabilitation therapy can help people with ongoing low back pain. You would connect with a specialist from home.
Baltimore, MarylandAges 18–64 - NCT06080464Recruiting
Doctor satisfaction with VERABAND™ for chronic low back pain
This study tests how satisfied doctors are with a wearable device called VERABAND™ that monitors movement in people with chronic low back pain. If your pain limits your ability to move, you may be able to help researchers understand if this device is useful during your regular non-surgical treatment.
La Jolla, CaliforniaAges 18–85 - NCT06706479Enrolling by invitation
Brain stimulation for balance in older adults with back pain
This study tests whether a gentle, non-invasive electrical brain stimulation technique (called high-definition tDCS) can improve balance in older adults with chronic low back pain. Participants receive either real or sham stimulation during balance training sessions.
Hong Kong, Hong KongAges 60–85 - NCT07709416Recruiting
Testing toludesvenlafaxine for long-lasting low back pain
This study tests an experimental medication called toludesvenlafaxine to see if it can help people with long-lasting low back pain that has no clear cause. If you have moderate to severe lower back pain for more than 3 months and haven't taken antidepressants before, this may be an option for you to explore.
BeijingAges 18–75 - NCT05963451Recruiting
Testing treatments for long-term low back pain from facet joints
This study focuses on people with long-lasting low back pain that likely comes from the small “facet” joints in the lower spine. It aims to better understand brain, psychological, and biology changes to help optimize treatment for this type of back pain.
Sherbrooke, QuebecAges 18–75 - NCT06568198RecruitingPhase 2
Brain stimulation study for chronic low back pain
This trial tests whether a noninvasive brain stimulation technique called tACS can help reduce chronic low back pain. Participants will have brain scans and receive the treatment over several sessions.
Charlestown, MassachusettsAges 18–60 - NCT07675304RecruitingEarly Phase 1
Mesotherapy for chronic low back pain study
This trial tests whether injecting a natural substance (collagen) into the lower back can safely reduce chronic pain. It may help people with pain that hasn't spread to the legs.
WarsawAges 18–65 - NCT06347991Recruiting
Chiropractic self-care app study for back pain in Alberta
This study tests an app called SelfBack that helps chiropractic patients manage their own long-term low back pain. You will use your smartphone to receive personalized exercises and tips. It may help you take control of your back pain between chiropractic visits.
Edmonton, AlbertaAges 18 years+
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Common questions
- Are there clinical trials for chronic low back pain?
- Yes. Clin2 currently lists 270 recruiting chronic low back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic low back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic low back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.