Clinical trials
Chronic Low Back Pain clinical trials
Below are recruiting chronic low back pain clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04783454Recruiting
Preventing neck and back pain in teleworkers
This study tests ways to prevent neck and back pain in people who work at a computer from home or an office. If you qualify, you may be assigned to an intervention aimed at reducing pain and improving comfort.
Ghent, East FlandersAges 18–69 - NCT03912519Enrolling by invitation
Testing two ways to numb lumbar back pain with radiofrequency
This study compares two needle-based techniques to treat long-lasting low back pain by stopping overactive pain signals from specific back joints. If you’ve already tried physical therapy and pain medicines without enough relief, this trial may test which technique works better for pain reduction.
Nashville, TennesseeAges 40 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT05066334RecruitingPhase 2
Back pain trial using your own stem cells in discs
This Phase 2 trial tests whether injecting your own stem cells into a few back discs can reduce chronic low back pain that has not improved with standard treatments. It may help by targeting disc-related (degenerative) wear seen on MRI, but it requires detailed MRI and blood test screening.
Roma, ItalyAges 18–65 - NCT05100381Recruiting
Dry needling for long-lasting lower back muscle pain
This study tests whether dry needling (thin needles placed into specific muscles) can reduce moderate, long-lasting lower back pain. It focuses on people who have pain from trigger points in a specific back muscle, rather than pain caused by other medical problems.
Tehran, Tehran ProvinceAges 18–45 - NCT05231265Recruiting
Lumbar surgery effect on walking complexity in chronic low back pain
This study looks at how lumbar spine surgery (fusion or artificial disc “prosthesis” on one or two levels) affects how complex your walking looks and feels. It may help doctors better understand what to expect from surgery and how it changes movement in people with long-term low back pain.
NîmesAges 18 years+ - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05422040Recruiting
Dry needling or tecartherapy for long-term low back pain
This study compares two physical therapies—dry needling versus tecartherapy—to see which helps people with long-lasting, non-specific low back pain. You may be eligible if your pain has lasted more than 6 weeks and is not caused by nerve or serious underlying conditions.
Alcalá de Henares, MadridAges 18–65 - NCT05452876RecruitingPhase 2
Back care program for adults with certain spine problems
This study tests a back-care pathway (a structured plan for care) for adults with specific spine-related conditions. It aims to see whether this approach improves care for people in Alberta who may benefit from organized back treatment and guidance.
Edmonton, AlbertaAges 18 years+ - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05511012Recruiting
Testing movement-control assessment in low back pain
This study checks whether a therapist’s judgment about how your back controls movement matches objective measurements (more technical testing). It may help improve how low back pain rehabilitation is assessed and planned.
Brest, FinistèreAges 18–99 - NCT05540548Recruiting
Podiatry assessment for balance and pain in chronic back pain
This study looks at whether a foot and posture specialist can help measure how balance relates to the pain you feel in chronic low back pain. It may help doctors better understand what to focus on for pain that lasts for months.
ValenciennesAges 18 years+ - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT05706103Recruiting
Exercise therapy for recurrent low back pain with brain changes
This trial studies whether a specific exercise program can improve recurrent low back pain by changing activity in muscles and the brain. If you have non-specific low back pain that comes and goes over time, you may be asked to do exercises and undergo brain and muscle testing (including MRI).
Ghent, Oost-VlaanderenAges 18–45 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05776771Recruiting
Spine movement study for people with back or neck pain
This study measures how your spine and back/neck move using motion testing and equipment. It may help researchers better understand differences between people with spine pain and people without.
Columbus, OhioAges 18 years+ - NCT05832918Recruiting
Core exercises plus brain tasks for chronic low back pain
This study tests whether doing core (stability) exercises along with simple cognitive (thinking) tasks can reduce long-lasting low back pain. It may help if your pain has lasted at least 3 months and you can safely take part in exercise.
Tehran, Iran (the Islamic Republic Of)Ages 18–55 - NCT05840302Recruiting
Pain education program to increase activity in chronic low back pain
This trial studies whether teaching “pain neuroscience” (how pain works in the body and brain) helps people with long-term low back pain move more. It compares an education program as part of a multidisciplinary rehab to usual care during your planned hospital stay.
Lamalou-les-BainsAges 18 years+
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Common questions
- Are there clinical trials for chronic low back pain?
- Yes. Clin2 currently lists 270 recruiting chronic low back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic low back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic low back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.