Clinical trials
Chronic Migraine Headache clinical trials
Below are recruiting chronic migraine headache clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+ - NCT07159750Recruiting
Study on new migraine drugs in real life
This study tracks how well new migraine medications (like Aimovig, Emgality, Ajovy, Vyepti, Qulipta, and Nurtec) work in everyday use. It may help you and your doctor understand if these treatments are a good option for your migraines.
Miami, FloridaAges 18 years+ - NCT07223008Recruiting
Bilateral artery embolization for chronic migraine
This trial tests a procedure called bilateral middle meningeal artery embolization to see if it reduces chronic migraine symptoms in people who haven't found relief from other treatments. It's for those with frequent, disabling migraines that affect both sides of the head.
Baltimore, MarylandAges 18–80 - NCT07348783Recruiting
Yoga for chronic migraine and cluster headache
This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.
HuddingeAges 18–65 - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study
This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.
Barcelona, BarcelonaAges 18 years+ - NCT06485336RecruitingPhase 2
Atorvastatin for prevention of chronic migraine
This trial tests whether the cholesterol drug atorvastatin can reduce the number of migraine days in people with chronic migraine (15 or more headache days per month, including at least 8 migraine days). If you have frequent migraines and haven't tried statins before, this study may offer a new preventive option.
BergenAges 18–65 - NCT07015411Recruiting
Neuro supplements for migraine prevention
This trial tests whether a combination of vitamins and supplements can help prevent migraines. It's for adults who have migraines often (at least 6 days per month) and want to try a non-drug option.
MechelenAges 18–75 - NCT06322407Recruiting
Ultrasound-guided neck injection for treating chronic migraine
This study tests whether a nerve block injection near the neck (called stellate ganglion block), guided by ultrasound, can reduce chronic migraine pain. It may be a good option if you have chronic migraine and haven't found relief from standard preventive medications.
Beijing, Beijing MunicipalityAges 18–65 - NCT06549270Recruiting
Biochemical study of migraine patients
This trial looks at the chemical changes in the blood of people with migraine. It aims to better understand the disease and may help find new treatments. You may qualify if you have episodic or chronic migraine and have not tried CGRP-targeting drugs.
PaviaAges 18–75 - NCT06974617Recruiting
Nerve block vs. Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (sphenopalatine block) and Botox injections. It aims to see which one works better for reducing headache days.
CairoAges 18–65 - NCT07698249Enrolling by invitation
Headache diary for migraine patients
This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.
Edison, New JerseyAges 18 years+ - NCT06562413Recruiting
Finding New Biological Clues in Hard-to-Treat Migraine
This study looks for new biological markers in people whose migraines don't respond to standard treatments. It aims to better understand why some migraines are hard to treat and may help guide future therapies.
PaviaAges 18–75 - NCT06562400Recruiting
New treatments for resistant migraine
This trial is testing new approaches for people whose migraines haven't improved with multiple preventive treatments. The goal is to find better options for those with hard-to-treat migraine.
PaviaAges 18–75 - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT05337033RecruitingPhase 2
Testing cannabis for chronic headaches in teens
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
Vancouver, British ColumbiaAges 14–17 - NCT05903027Recruiting
Testing gepant migraine treatment for better side effects
This trial studies how well a “gepant” medicine works for different types of migraine and how tolerable it is. It may help if you have frequent migraines and you can keep a headache diary as the study asks.
FlorenceAges 18 years+ - NCT06461767Recruiting
rTMS for chronic migraine without recent prevention
This study tests whether repetitive transcranial magnetic stimulation (rTMS) — a noninvasive treatment using magnetic pulses on the head — can help prevent and treat chronic migraine pain. It may be an option for people who have never tried or are currently off migraine prevention medicines.
SohagAges Any age - NCT03404336Recruiting
Well-being therapy for chronic migraine in outpatients
This study tests whether a “well-being therapy” program can reduce symptoms of chronic migraine compared with a control therapy. You may qualify if you have long-lasting chronic migraine and can follow the study schedule.
Florence, FlorenceAges 18–65 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT03972124RecruitingPhase 2
Cannabis to prevent migraine attacks before they start
This Phase 2 trial tests whether using cannabis can prevent migraine attacks from happening. It specifically looks at people with chronic migraine who have tried and not benefited from other prevention medicines.
Calgary, AlbertaAges 25 years+
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Common questions
- Are there clinical trials for chronic migraine headache?
- Yes. Clin2 currently lists 67 recruiting chronic migraine headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic migraine headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic migraine headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.