Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06674772Recruiting
Migraine study measuring CGRP levels by age and sex
This study measures a substance called CGRP in saliva from people with migraine and healthy volunteers to see how it changes with age and sex. It may help researchers understand migraine better.
Barcelona, BarcelonaAges 6–75 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT04715685Recruiting
Mind-body balance program for children with migraine
This trial studies a mind-body balance approach to help reduce symptoms and disability from pediatric migraine. You may join if your child has migraine headaches and can follow study routines, including keeping a headache diary.
Aurora, ColoradoAges 10–17 - NCT07348783Recruiting
Yoga for chronic migraine and cluster headache
This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.
HuddingeAges 18–65 - NCT07022496RecruitingPhase 4
Can oral caffeine help with acute migraine attacks?
This trial tests whether taking caffeine by mouth can reduce the severity of a migraine attack when it happens. It may offer a simple, at-home option for people with different types of migraine.
CairoAges 18–60 - NCT06459635Recruiting
Migraine attack prediction study using smartphone tracking
This study uses a smartphone app or device to track your body signals and predict when a migraine attack is about to start. It is designed for people with frequent (10–14 days per month) migraines.
Madrid, MadridAges 18–65 - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT06203873Recruiting
Comparing biodegradable vs. metal heart-hole closures for migraine
This trial compares two types of devices (biodegradable vs. metal) to close a small hole in the heart (PFO) in people who have migraine not controlled by usual treatments. It aims to see which device works better to reduce migraine attacks.
Beijing, Beijing MunicipalityAges 18–65 - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT07021859Recruiting
Migraine with aura study using CGRP to trigger attacks
This study tests whether a substance called CGRP (a protein linked to migraines) can safely trigger a migraine with aura in people who already have this condition. You'll receive an infusion and be monitored to see how your body responds.
Glostrup MunicipalityAges 18–65 - NCT07642414Recruiting
Digital program combining exercises and mindfulness for migraines
This 12-week online program uses exercises, mindfulness, and digital tracking to help reduce migraines. You'll work with the app on your smartphone while staying on your current migraine medications.
San Francisco, CaliforniaAges 18 years+ - NCT05903027Recruiting
Testing gepant migraine treatment for better side effects
This trial studies how well a “gepant” medicine works for different types of migraine and how tolerable it is. It may help if you have frequent migraines and you can keep a headache diary as the study asks.
FlorenceAges 18 years+ - NCT06409832Recruiting
Study of rimegepant for migraine prevention
This study tests a medicine called rimegepant to see if it helps prevent migraines. If you have migraine at least 4 days per month, this might be for you.
Florence, FlorenceAges 18 years+ - NCT05484349RecruitingPhase 3
Tizanidine to prevent frequent migraine attacks
This Phase 3 trial tests tizanidine to help prevent migraine attacks. If you have frequent migraine with or without aura, it compares tizanidine against placebo while tracking your headaches in diaries.
Luzhou, SichuanAges 18–65 - NCT06921109Recruiting
Virtual reality for headache relief in kids
This study tests if using virtual reality to learn relaxation techniques can help reduce headaches in children and teens who have migraines or frequent tension headaches.
Sart Tilman, LiegeAges 8–15 - NCT06716489Recruiting
Exercise study for women with migraine
This study tests whether aerobic exercise can help reduce migraine symptoms and improve how your body senses and responds to pain. It is specifically for women aged 18–48 who have migraine headaches 3–8 days per month.
Ribeirão Preto, São PauloAges 18–48 - NCT05334927Recruiting
Headache disorder registry for teens and adults with primary headaches
This study is a headache disorder registry that enrolls people with common, “primary” headache types such as migraine or tension headache, including some with medication-overuse headaches. It collects information to better understand these conditions and who they affect.
Anqing, AnhuiAges 12 years+ - NCT07719608Recruiting
MySalvia system for resistant migraine
This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.
Newnan, GeorgiaAges 22–84 - NCT07754266Recruiting
Headache, ear, and dizziness registry
This study collects information from people who have headaches, ear problems, dizziness, or sinus issues to better understand these symptoms and how they relate to migraine. Your participation may help improve future treatments and diagnosis.
North Kingstown, Rhode IslandAges 18 years+ - NCT04939922Recruiting
Headache and dizziness registry for people with headache disorders
This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.
Hangzhou, ZhejiangAges 4–99 - NCT05418218Recruiting
International headache registry for people with headache diagnoses
This study collects information from people who have headaches to better understand different headache types. You may help researchers by keeping headache records and allowing follow-up over time.
Hangzhou, ZhejiangAges 4–99 - NCT06277063Recruiting
Nerve-stimulation device for headache in children and young adults
This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.
Guangzhou, GuangdongAges 7–20 - NCT05415020Recruiting
Behavior program for chronic migraine
This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 194 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.