Clinical trials · Boston, MA
Chronic pain clinical trials in Boston
We’re tracking 45 recruiting chronic pain studies with a site in or near Boston — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT04689646Recruiting
Mind-body therapy for chronic back pain
This study tests whether a mind-body therapy approach can reduce disability and how bothersome chronic back pain feels. It may help people whose pain has lasted for months and affects daily life.
Boston, MassachusettsAges 18–67 - NCT07023523Recruiting
Controlling brain activity for chronic pain
This study tests if people with fibromyalgia can learn to control their own brain activity using real-time feedback from an MRI machine to reduce pain. It is designed to help those with long-term chronic pain find new ways to manage it.
Boston, MassachusettsAges 18–65 - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+ - NCT06673108RecruitingPhase 2
Light therapy for chronic pelvic pain
This trial tests a light therapy device placed inside the vagina to treat long-term pelvic pain. It may help people whose pain hasn't been helped by other treatments.
Boston, MassachusettsAges 18 years+ - NCT06632535Recruiting
Group visits and chiropractic care for older adults with chronic spine pain
This study tests whether group medical visits combined with chiropractic care can help older adults with chronic neck or back pain. If you join, you'll receive chiropractic treatments and attend group visits to learn pain management strategies.
Boston, MassachusettsAges 65 years+ - NCT06106191Recruiting
Mindfulness program for chronic low back pain
This trial tests a mindfulness-based program designed to help people with long-term low back pain. It aims to see if combining mindfulness with a personalized approach can improve pain management and daily functioning.
Boston, MassachusettsAges 18 years+ - NCT05701982Recruiting
Walking plus Tai Chi coach via video for COPD and pain
This study tests whether a phone/computer program that combines walking training with Tai Chi improves physical function (how well you move) in people who have COPD and long-term body or muscle pain. It may help you build strength, balance, and safer movement—especially if pain makes activity hard.
Boston, MassachusettsAges 40–100 - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Boston, MassachusettsAges 18–75 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Boston, MassachusettsAges 18 years+ - NCT06095050Recruiting
Embolization for chronic shoulder pain
This trial tests a procedure called embolization to treat long-lasting shoulder pain that hasn't improved with other treatments like physical therapy or injections. The goal is to see if blocking certain blood vessels can reduce pain and improve function.
Boston, MassachusettsAges 21–80 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Boston, MassachusettsAges 12–17 - NCT00499317Recruiting
Genetic study of chronic pelvic pain and bladder symptoms
This study looks for genetic (inherited) factors behind chronic pelvic pain and related urinary and sexual symptoms. You may be able to help researchers by providing a few samples and answering short questions, which could improve understanding of these conditions.
Boston, MassachusettsAges Any age - NCT07118722Recruiting
Quiet focus: mindfulness for pain and depression
This study compares two programs—mindfulness-based therapy and a general health program—to see which better helps older Black adults manage long-term pain and mild depression. It aims to find new ways to improve well-being.
Boston, MassachusettsAges 50–120 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT05304286Recruiting
Study of brain and pain in long-lasting post-surgery pain
This trial studies what’s happening in the brain and how pain is processed in people with pain that lasts long after surgery. It may help researchers understand chronic post-surgical pain and find better ways to treat it.
Boston, MassachusettsAges 12 years+ - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Boston, MassachusettsAges 18 years+ - NCT06119698Recruiting
Improving Health for Older Adults With Pain Through Engagement
This study tests a program to help older adults with long-lasting bone, joint, or muscle pain become more active. Participants wear a smartwatch and get support to manage their pain and improve their health.
Boston, MassachusettsAges 55 years+ - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Boston, MassachusettsAges 18 years+ - NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT06870162Recruiting
Pain disengagement training: a writing study for chronic pain
This study tests a writing-based program to help people with chronic pain learn to disengage from pain-related thoughts. It aims to reduce pain catastrophizing and improve daily function.
Boston, MassachusettsAges 18 years+
Hear when a new Chronic pain trial opens near Boston, MA
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Chronic pain trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting chronic pain studies listed above.
- Massachusetts General Hospital · 8 studies
- Brigham and Women's Hospital · 4 studies
- Beth Israel Deaconess Medical Center · 3 studies
- Boston Children's Hospital · 2 studies
- Mass General Brigham · 2 studies
- VA Boston Healthcare System Jamaica Plain Campus · 2 studies
- ActivMed Practices and Research
- Athinoula A. Martinos Center for Biomedical Imaging
What taking part in a chronic pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting chronic pain studies in Massachusetts.
Common questions
- Are there chronic pain clinical trials near Boston?
- Yes. We're currently tracking 45 recruiting chronic pain studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a chronic pain study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New chronic pain studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.