Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 828 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07639060Recruiting
Pain Relief Study Using Freezing Nerve Treatment
This study watches how well a freezing procedure works for chronic pain over 6 to 12 months. Your doctor thinks this procedure could help your pain, and the study simply tracks your recovery through questionnaires to help doctors understand if it works.
Old Saybrook, ConnecticutAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07641504RecruitingPhase 2
Testing LY4065967 for chronic low back pain relief
This study tests whether a new medication called LY4065967 can reduce chronic low back pain. Researchers want to see if it works better than current treatments for people who have had lower back pain for at least 3 months.
Birmingham, AlabamaAges 18 years+ - NCT07696741Recruiting
Pain Reprocessing Therapy for Chronic Lower Back Pain
This study tests a type of talk therapy called pain reprocessing therapy (PRT) for adults with chronic lower back pain. The goal is to see if PRT can help reduce pain and improve quality of life.
Toronto, OntarioAges 18–65 - NCT07766200Recruiting
Pain types in people with long-term low back pain
This study looks at different types of chronic low back pain. It aims to understand how pain affects people differently, which might help improve future treatments.
Kütahya, TürkiyeAges 18–70 - NCT04014829Recruiting
Study of pain processing after planned hysterectomy
This trial looks at how the nervous system and fear of pain may affect pain after a planned hysterectomy. If you qualify, you may be asked about pain levels and pain sensitivity to better understand who may have more pain recovery challenges.
SingaporeAges 21–80 - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT06387706Recruiting
Web-based pain program for older adults
This study tests a fun, web-based program (GAP) to help older adults manage chronic pain through light exercise and coping skills. It's designed for Cantonese speakers who can use a smartphone.
Hong KongAges 60 years+ - NCT07630350Enrolling by invitation
Virtual Reality for Young People With Chronic Pain
This study tests whether wearing virtual reality goggles can help young people (ages 7–21) manage chronic pain in their neck, shoulders, or arms. Researchers want to see if VR activities can reduce pain and improve daily life.
Allison Park, PennsylvaniaAges 7–21 - NCT06317233Enrolling by invitation
Team-based program for chronic pelvic pain in women
This research study tests a team-based program for women with ongoing pelvic pain. The goal is to see if a coordinated approach with different specialists can help manage pain and improve quality of life.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06288282Recruiting
Predicting pain and opioid misuse in chronic back pain
This study looks at how thinking and behavior affect long-term pain and opioid use in people with chronic lower back pain. It aims to find better ways to manage pain and prevent medication misuse.
New York, New YorkAges 18 years+ - NCT06778070Recruiting
Pelvic pain study testing yoga therapy for relief
This trial tests whether yoga therapy can help reduce chronic pelvic pain in women and non-binary individuals over 6 months. You'll join online yoga classes and see if they improve your pain and daily life.
San Francisco, CaliforniaAges 18 years+ - NCT06741579RecruitingPhase 3
Pain relief study for nerve injury pain
This trial tests how well two types of peripheral nerve stimulation (PNS) devices relieve chronic pain caused by a single nerve injury. It looks for people who already have a referral for PNS therapy as part of their usual care and who have gotten at least 50% relief from a diagnostic nerve block.
Palo Alto, CaliforniaAges 18 years+ - NCT07001449Recruiting
Pain education for chronic muscle or joint pain
This study tests a type of pain education that focuses on communication to help people with long-term muscle or joint pain. It aims to see if learning about pain in a new way can help reduce symptoms and improve quality of life.
Lamia, Central GreeceAges 18–65 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85 - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT07717151Recruiting
Preventing long-term pain after surgery for chronic opioid users
This trial tests a method to prevent chronic pain after surgery in people who already take opioids regularly. It may help reduce long-term pain and improve recovery.
AmiensAges 18 years+ - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT04512755Recruiting
AIMS medical outcomes study for new or established patients
This is an observational study where the AIMS team collects information from patients during a first visit or ongoing care. It helps the clinic understand patients’ experiences and outcomes, but it does not test a new medicine.
Seattle, WashingtonAges Any age - NCT04546685Recruiting
Spanish online group program to help manage long-term pain
This trial tests a one-time, Spanish-language online group program (“Empowered Relief”) for people with long-term pain. It may help you learn coping skills and strategies to reduce the impact of chronic pain.
Palo Alto, CaliforniaAges 18 years+ - NCT04587791RecruitingEarly Phase 1
Cannabidiol (CBD) for opioid use disorder and chronic pain
This early study tests whether CBD can reduce symptoms of chronic pain in people receiving opioid maintenance treatment for opioid use disorder. It also looks at safety and whether CBD can be added without causing major problems.
West Haven, ConnecticutAges 18–70 - NCT04662905Recruiting
Testing a closed-loop spinal cord stimulator for chronic pain
This study tests a new way to deliver spinal cord stimulation for chronic pain using a system that adjusts automatically based on what your body is doing. You may be able to join if you’re using the Evoke system as part of the approved treatment plan.
Garran, Australian Capital TerritoryAges 18 years+ - NCT04689646Recruiting
Mind-body therapy for chronic back pain
This study tests whether a mind-body therapy approach can reduce disability and how bothersome chronic back pain feels. It may help people whose pain has lasted for months and affects daily life.
Boston, MassachusettsAges 18–67
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Chronic pain trials by city
Studies with a site in or near these metro areas.
Chronic pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 828 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.