Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 792 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07432685Enrolling by invitation
Can movement predict chronic pain after combat limb injuries?
This study is looking for people with combat-related arm or leg injuries to see if how they move can predict long-term pain. Researchers hope to better understand who might develop chronic pain and help improve treatment.
LvivAges 18–50 - NCT07426367Recruiting
Online therapy for chronic pain and emotional distress
This trial tests an online therapy program that uses acceptance and commitment therapy (ACT) to help people with chronic pain who also feel anxious or depressed. The goal is to improve emotional well-being and daily functioning.
LundAges 18–65 - NCT07432425Recruiting
Exercise programs for chronic neck pain
This study compares different exercise programs to see which one improves physical and mental health in people with chronic neck pain. You may be eligible if you have had neck pain for at least 3 months and it is moderate to severe, but you haven't been in a recent neck pain rehab or exercise program.
Ankara, AltindagAges 20–65 - NCT07404618Recruiting
Video pain relief study for older adults
This study tests a video program to help older adults with ongoing muscle or joint pain learn skills to manage pain and improve daily life. It may be a good fit if pain has been bothering you most days for at least 3 months and gets in the way of your normal activities.
Providence, Rhode IslandAges 55 years+ - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT07331766Enrolling by invitation
Collaborative care for chronic pain patients
This trial tests a team-based treatment approach for people with chronic pain. You'll work with at least two pain clinic specialists to create a care plan that fits your needs.
Ottestad, InnlandetAges 18 years+ - NCT07325110Recruiting
Teens with chronic pain: yoga in occupational therapy
This study looks at whether adding yoga to occupational therapy helps teens with chronic pain better understand their body's signals. It aims to improve daily function and well-being.
Hartford, ConnecticutAges 11–21 - NCT07318519Recruiting
Virtual reality for chronic cancer pain
This study tests whether virtual reality (VR) can help reduce chronic pain in people with cancer. If you have had cancer pain for at least three months and rate your pain as 4 or more out of 10, you may be able to join.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT07287501Recruiting
Pain education and exercise for older adults with chronic pain
This trial is for older adults (65+). It combines pain science education with exercise to help manage chronic pain. You'll learn about how pain works and practice exercises designed to reduce pain and improve movement.
Salamanca, SalamancaAges 65 years+ - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT07266103Recruiting
Personalized brain stimulation for chronic pain study
This study tests whether personalized sessions of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help reduce chronic pain. It aims to understand how this treatment works and how it might be tailored to individuals.
GistrupAges 18–80 - NCT07225049Recruiting
Integrated treatment for PTSD and chronic pain
This study tests a combined therapy for people who have both PTSD and chronic pain. It aims to see if treating both conditions together is more helpful than treating them separately.
New York, New YorkAges 18 years+ - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT07207174Recruiting
Mindfulness vs CBT for chronic pain relief
This study compares two non-drug treatments—mindfulness training and cognitive-behavioral therapy—to see which helps adults with chronic pain better. Both aim to reduce pain and improve quality of life.
Tallahassee, FloridaAges 18 years+ - NCT07194239Recruiting
Lifestyle medicine for chronic pain in older adults
This trial tests if lifestyle changes like diet and exercise can reduce chronic muscle or joint pain in older adults. It focuses on people with long-lasting pain from conditions like arthritis.
Hong KongAges 60 years+ - NCT07190807Recruiting
Optimizing spinal cord stimulation for chronic back and leg pain
This trial tests if a spinal cord stimulator with a new way of adjusting electrical settings (called independent current control) can better manage chronic pain in the back, trunk, or limbs. The goal is to find more effective sequences to reduce pain and improve daily life.
Greenwood, ColoradoAges 18 years+ - NCT07179016Recruiting
Acupressure for chronic pain in rural areas
This trial tests if a self-managed acupressure program can help people living in rural areas manage long-term muscle or joint pain, like neck, back, or knee pain. You would learn to press small seeds on your ear to ease pain.
Columbia, South CarolinaAges 18–85 - NCT07001449Recruiting
Pain education for chronic muscle or joint pain
This study tests a type of pain education that focuses on communication to help people with long-term muscle or joint pain. It aims to see if learning about pain in a new way can help reduce symptoms and improve quality of life.
Lamia, Central GreeceAges 18–65 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT07137715Recruiting
Wellness and recovery for veterans with chronic back or neck pain
This study tests a psychological program to help veterans manage chronic back or neck pain. It aims to improve your wellbeing and daily function through counseling or coaching sessions.
Aurora, ColoradoAges 18 years+ - NCT06208514Recruiting
Brief Pain Exposure Therapy for chronic pain conditions
This study tests a type of talk therapy called Brief Pain Exposure Therapy (BPET) for people with certain chronic pain conditions like fibromyalgia, lupus, or chronic low back pain. It aims to help reduce pain by changing how your brain responds to it.
Ann Arbor, MichiganAges 18 years+ - NCT06574009RecruitingPhase 4
Better options for chronic cancer pain in veterans
This study tests if switching from long-term opioid painkillers to buprenorphine (a different type of pain medication) can provide better pain relief for veterans who have had cancer but are currently cancer-free. It aims to find a safer and more effective way to manage chronic pain.
Indianapolis, IndianaAges 18–99
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Chronic pain trials by city
Studies with a site in or near these metro areas.
Chronic pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 792 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.