Clinical trials
Class I Malocclusion clinical trials
Below are recruiting class i malocclusion clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07162753Recruiting
Ethnic bias check in AI orthodontic diagnosis
This trial checks if an AI system for orthodontic diagnosis works equally well for people of different ethnic backgrounds. You may be eligible if you have a side-view face photo taken before braces or similar treatment.
Istanbul, FatihAges 4 years+ - NCT07773389Recruiting
Early vs late premolar removal for braces
This study compares removing two back teeth early versus later during braces treatment to see which timing leads to better tooth movement. It may help teens and young adults needing braces for crowded teeth or overbite.
IslamabadAges 13–25 - NCT07710391Recruiting
3D printed brace for children with underbite
This trial tests a special 3D-printed brace to fix underbite in children aged 8-13 who still have growing upper jaws. The brace encourages the upper jaw to grow forward and corrects the bite.
BaghdadAges 8–13 - NCT05684510Recruiting
Clear aligners vs braces for mild overbite in adults
This trial compares clear plastic aligners with fixed braces to improve mild overbite (Class II) in adults who have not had orthodontics before. It may help you understand which option works better for your bite and alignment while also checking fit and dental health needs.
Hama, Hama GovernorateAges 15–20 - NCT07703007Enrolling by invitation
Clear aligners for growing kids with mild underbite
This study tests whether clear aligners can fix a mild underbite in growing children aged 8 to 11. It compares how well the aligners move teeth and jaws compared to other treatments.
Al Mansurah, Dakahlia GovernorateAges 8–11 - NCT06984666Enrolling by invitation
Study of facial profiles at 45 degrees
This study looks at facial features from a 45-degree angle to see what makes a beautiful profile. It includes orthodontists, patients who have had braces for over a year, and adults without braces experience. You will have photos taken and answer some questions.
Fuzhou, FujianAges 18–50 - NCT07466641Recruiting
Low-level laser or Piezocision to speed up canine tooth movement
This trial compares two treatments to see if they can safely speed up a specific tooth movement during braces. It tests a low-level laser or a minor surgical procedure called Piezocision against standard care.
Cairo, Cairo GovernorateAges 18–25 - NCT05950581Recruiting
Twin-block braces with clear plates for jaw misalignment
This study tests a removable orthodontic device (twin-block with clear plates) to improve how the upper and lower jaws fit together in children. It may help if you have a specific “Class II” jaw pattern caused mainly by a lower jaw that sits back.
HamaAges 10–13 - NCT07376954Enrolling by invitationPhase 1
Bite correction for children with underbite
This trial tests a special dental device that is glued to the teeth to correct an underbite in children aged 8-11. It aims to improve the way the upper and lower jaws fit together.
Al MansurahAges 8–11 - NCT07340242Recruiting
3D-Printed Braces vs. MARA for jaw alignment
This trial compares two types of braces (a 3D-printed removable brace and a fixed brace called MARA) to see which works better for correcting a bite problem where the lower jaw is too far back. It is designed for teenagers who are still growing and have a large overbite.
Al Mansurah, Dakahlia GovernorateAges 9–14 - NCT07405905Recruiting
Comparing mini implant placements for fixing upper teeth overbite
This study tests two ways of placing small temporary anchors (mini implants) in the jaw to help pull upper front teeth back into a better position. It is for patients who have finished growing and have a Class II overbite, to see which anchor location works best.
Rohtak, HaryanaAges 18–30 - NCT07676695Recruiting
Jaw Device and Sound Waves for Class II Malocclusion
This trial tests a special jaw repositioning device (Twin-Block) combined with low-intensity sound waves (LIPUS) to help treat a class II malocclusion (when the lower jaw is set back) in children and teens. It aims to improve jaw alignment and joint outcomes.
CairoAges 10 months–1.2 years - NCT07752498Enrolling by invitation
Long-term results from twin block treatment
This study checks whether the results from an earlier treatment with the Twin Block appliance, which corrects bite problems, hold up over time. It looks at how stable the teeth and jaw remain years after treatment.
Jönköping, Jönköping CountyAges Any age - NCT07307209Recruiting
Comparing two ways to move upper teeth backward with tiny screws
This trial compares two methods (sliding jigs vs retraction hooks) to move your upper teeth backward using small screws placed in your jawbone. It may help if you have a mild overbite or crowded upper teeth and want to avoid removing teeth.
SanaaAges 14 years+ - NCT06759896Recruiting
Facemask vs braces for underbite in growing children
This trial compares a facemask device with upper braces to correct underbite in children ages 7–10. It aims to find which treatment works better to align the jaw and teeth.
Kuala Lumpur, Kuala LumpurAges 7–10 - NCT06943443Enrolling by invitation
Vitamin D and expander treatment for teens
This trial looks at whether vitamin D levels affect how well a special expander (MARPE) works to fix a narrow upper jaw in teens. If you are 15–18 and have a narrow upper jaw, you may be able to join.
Konya, MeramAges 16–18 - NCT05822271Recruiting
Surgery first plus aligners to improve jaw alignment
This trial studies how well a treatment plan works when you start with jaw surgery and then use clear aligners for orthodontic (teeth/jaw) finishing. It may help people whose jaw growth/position problems are mainly due to the lower jaw being too far forward or the upper jaw being too far back.
Rio de JaneiroAges 17–35 - NCT06511219Recruiting
Moving upper back teeth with a 3D-printed brace
This study tests a new 3D-printed dental device to move the upper back teeth backward in teenagers with an overjet (bucked teeth) and a class II bite. It may help correct the bite without removing teeth or using headgear.
Al MansurahAges 13–18 - NCT06651944Recruiting
Invisalign with jaw advancement aligners
This trial tests Invisalign clear aligners that also help move the lower jaw forward. It may be a good fit if you need both teeth straightening and jaw positioning help.
Richmond, British ColumbiaAges 10–16 - NCT06652230Recruiting
Comparing two ways to place braces for a better smile
This study compares two methods of placing braces to improve smile appearance. It tests if using the natural curve of your smile works better than a standard chart for bracket positioning.
Cairo, ManialAges 11–30 - NCT06944860Recruiting
3D-printed vs. traditional twin block braces for kids
This trial compares a new 3D-printed twin block brace to a traditional one for children with a large overbite (overjet ≥7 mm). It checks how well germs stick, how smooth the brace is, and how well it works—plus how children feel about it.
Kuala Lumpur, Kuala LumpurAges 10–14 - NCT07040176Recruiting
Moving upper back teeth back with aligners or mini-screws
This study compares two ways to move the upper back molars backward to fix an overbite where the upper teeth stick out too far. One method uses clear aligners, the other uses tiny temporary screws in the jawbone.
ThessalonikiAges Up to 30 years - NCT07361172Recruiting
Ready-made vs custom-made braces for jaw correction
This trial compares two types of orthodontic appliances to correct a Class II bite (where the upper teeth sit too far forward). It tests whether a custom-made device works better than a ready-made one for teens.
Al Mansurah, AdakhliaAges 12–16 - NCT07521267Recruiting
Nano-coated screws for teeth straightening in teens
This trial tests special small screws coated with nano-material to help move upper front teeth back into place during braces treatment. The screws act as anchors to make tooth movement more effective for patients with protruding upper front teeth.
Cairo, Cairo GovernorateAges 14–20
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Common questions
- Are there clinical trials for class i malocclusion?
- Yes. Clin2 currently lists 29 recruiting class i malocclusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a class i malocclusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a class i malocclusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.