Clinical trials
Malocclusion clinical trials
Below are recruiting malocclusion clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04117360Recruiting
Speech therapy study for people after jaw alignment surgery
This study looks at how well people can make specific speech sounds before and after jaw alignment treatment. It may help researchers understand whether speech patterns improve with treatment in people with certain bite differences.
Chapel Hill, North CarolinaAges 15–40 - NCT07162753Recruiting
Ethnic bias check in AI orthodontic diagnosis
This trial checks if an AI system for orthodontic diagnosis works equally well for people of different ethnic backgrounds. You may be eligible if you have a side-view face photo taken before braces or similar treatment.
Istanbul, FatihAges 4 years+ - NCT05038865Recruiting
How jaw alignment affects teens’ quality of life
This study compares how different types of bite/jaw alignment affect adolescents’ daily comfort and oral-health-related quality of life. It’s mainly done by asking teens to complete questionnaires and comparing groups with and without malocclusion.
Malmö, Skåne CountyAges 12–19 - NCT05684510Recruiting
Clear aligners vs braces for mild overbite in adults
This trial compares clear plastic aligners with fixed braces to improve mild overbite (Class II) in adults who have not had orthodontics before. It may help you understand which option works better for your bite and alignment while also checking fit and dental health needs.
Hama, Hama GovernorateAges 15–20 - NCT06858670Recruiting
A device to correct deep curve in back molars
This trial tests a small device (auxiliary segmental lingual appliance) placed on the inside of your lower back teeth to help correct a deep curve in your bite. It may be an option for people already in braces whose second molars tilt inward.
HanoiAges 18 years+ - NCT07773389Recruiting
Early vs late premolar removal for braces
This study compares removing two back teeth early versus later during braces treatment to see which timing leads to better tooth movement. It may help teens and young adults needing braces for crowded teeth or overbite.
IslamabadAges 13–25 - NCT07703007Enrolling by invitation
Clear aligners for growing kids with mild underbite
This study tests whether clear aligners can fix a mild underbite in growing children aged 8 to 11. It compares how well the aligners move teeth and jaws compared to other treatments.
Al Mansurah, Dakahlia GovernorateAges 8–11 - NCT07376954Enrolling by invitationPhase 1
Bite correction for children with underbite
This trial tests a special dental device that is glued to the teeth to correct an underbite in children aged 8-11. It aims to improve the way the upper and lower jaws fit together.
Al MansurahAges 8–11 - NCT07710391Recruiting
3D printed brace for children with underbite
This trial tests a special 3D-printed brace to fix underbite in children aged 8-13 who still have growing upper jaws. The brace encourages the upper jaw to grow forward and corrects the bite.
BaghdadAges 8–13 - NCT03513003Recruiting
Pacifier use to improve misaligned baby teeth
This study tests whether using a pacifier can help correct common misalignments in young children’s baby teeth and bite. It may help children whose upper and lower teeth don’t meet properly, with or without tongue thrust.
BaselAges 2–5 - NCT05950581Recruiting
Twin-block braces with clear plates for jaw misalignment
This study tests a removable orthodontic device (twin-block with clear plates) to improve how the upper and lower jaws fit together in children. It may help if you have a specific “Class II” jaw pattern caused mainly by a lower jaw that sits back.
HamaAges 10–13 - NCT07405905Recruiting
Comparing mini implant placements for fixing upper teeth overbite
This study tests two ways of placing small temporary anchors (mini implants) in the jaw to help pull upper front teeth back into a better position. It is for patients who have finished growing and have a Class II overbite, to see which anchor location works best.
Rohtak, HaryanaAges 18–30 - NCT07466641Recruiting
Low-level laser or Piezocision to speed up canine tooth movement
This trial compares two treatments to see if they can safely speed up a specific tooth movement during braces. It tests a low-level laser or a minor surgical procedure called Piezocision against standard care.
Cairo, Cairo GovernorateAges 18–25 - NCT06984666Enrolling by invitation
Study of facial profiles at 45 degrees
This study looks at facial features from a 45-degree angle to see what makes a beautiful profile. It includes orthodontists, patients who have had braces for over a year, and adults without braces experience. You will have photos taken and answer some questions.
Fuzhou, FujianAges 18–50 - NCT07752498Enrolling by invitation
Long-term results from twin block treatment
This study checks whether the results from an earlier treatment with the Twin Block appliance, which corrects bite problems, hold up over time. It looks at how stable the teeth and jaw remain years after treatment.
Jönköping, Jönköping CountyAges Any age - NCT06409923RecruitingPhase 1
Comparing Herbst vs Invisalign for jaw alignment in teens
This trial compares two different braces (a Herbst appliance and Invisalign MA) to see which works better for teenagers whose upper jaw is too far forward. It's for kids who are still growing and have a specific type of overbite.
AnderlechtAges Up to 15 years - NCT07307209Recruiting
Comparing two ways to move upper teeth backward with tiny screws
This trial compares two methods (sliding jigs vs retraction hooks) to move your upper teeth backward using small screws placed in your jawbone. It may help if you have a mild overbite or crowded upper teeth and want to avoid removing teeth.
SanaaAges 14 years+ - NCT06759896Recruiting
Facemask vs braces for underbite in growing children
This trial compares a facemask device with upper braces to correct underbite in children ages 7–10. It aims to find which treatment works better to align the jaw and teeth.
Kuala Lumpur, Kuala LumpurAges 7–10 - NCT06943443Enrolling by invitation
Vitamin D and expander treatment for teens
This trial looks at whether vitamin D levels affect how well a special expander (MARPE) works to fix a narrow upper jaw in teens. If you are 15–18 and have a narrow upper jaw, you may be able to join.
Konya, MeramAges 16–18 - NCT07045779Recruiting
Tongue and mouth muscle patterns in children with open bite
This study looks at children with an anterior open bite to understand their tongue and mouth muscle patterns. It may help find better ways to treat this condition.
GhentAges 6–12 - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
KirikkaleAges 18–40 - NCT05822271Recruiting
Surgery first plus aligners to improve jaw alignment
This trial studies how well a treatment plan works when you start with jaw surgery and then use clear aligners for orthodontic (teeth/jaw) finishing. It may help people whose jaw growth/position problems are mainly due to the lower jaw being too far forward or the upper jaw being too far back.
Rio de JaneiroAges 17–35 - NCT06168695Recruiting
Treating front teeth crossbite to help children's speech
This study looks at how fixing a crossbite (where upper front teeth sit behind lower teeth) can improve speech in children. It may help kids who have trouble saying certain sounds because of their teeth alignment.
Tanta, Gharbia GovernorateAges 8–10 - NCT06315348Recruiting
Gum shaping during braces with a vibration tool
This trial tests a new, less invasive surgical technique (using a special tool that vibrates, not a scalpel) to help reshape the gums while straightening teeth with braces. It is for people who need braces for mild to moderate crowding and have healthy gums.
MadridAges 16–70
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Common questions
- Are there clinical trials for malocclusion?
- Yes. Clin2 currently lists 60 recruiting malocclusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malocclusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malocclusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.