Clinical trials
Malocclusion clinical trials
Below are recruiting malocclusion clinical trials, each written for real people, not researchers. We’re tracking 58 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04117360Recruiting
Speech therapy study for people after jaw alignment surgery
This study looks at how well people can make specific speech sounds before and after jaw alignment treatment. It may help researchers understand whether speech patterns improve with treatment in people with certain bite differences.
Chapel Hill, North CarolinaAges 15–40 - NCT05038865Recruiting
How jaw alignment affects teens’ quality of life
This study compares how different types of bite/jaw alignment affect adolescents’ daily comfort and oral-health-related quality of life. It’s mainly done by asking teens to complete questionnaires and comparing groups with and without malocclusion.
Malmö, Skåne CountyAges 12–19 - NCT07790315Recruiting
Clear aligner comfort study for mild to moderate crowding
This study tests two types of clear aligners to see which one feels more comfortable and works better for patients with mild to moderate crowding. It may help decide which aligner material is better for future patients.
Lahore, Punjab ProvinceAges 15–30 - NCT05684510Recruiting
Clear aligners vs braces for mild overbite in adults
This trial compares clear plastic aligners with fixed braces to improve mild overbite (Class II) in adults who have not had orthodontics before. It may help you understand which option works better for your bite and alignment while also checking fit and dental health needs.
Hama, Hama GovernorateAges 15–20 - NCT07841067Recruiting
3D-printed vs. milled plates for jaw surgery
This study compares two types of titanium plates (3D-printed vs. traditionally milled) used to hold the upper jaw in place after corrective jaw surgery. It aims to see which type is more accurate and reduces surgery time, which could mean a faster recovery for you.
Cairo, New Cairo, Fifth SettlementAges 18 years+ - NCT07773389Recruiting
Early vs late premolar removal for braces
This study compares removing two back teeth early versus later during braces treatment to see which timing leads to better tooth movement. It may help teens and young adults needing braces for crowded teeth or overbite.
IslamabadAges 13–25 - NCT07710391Recruiting
3D printed brace for children with underbite
This trial tests a special 3D-printed brace to fix underbite in children aged 8-13 who still have growing upper jaws. The brace encourages the upper jaw to grow forward and corrects the bite.
BaghdadAges 8–13 - NCT07703007Enrolling by invitation
Clear aligners for growing kids with mild underbite
This study tests whether clear aligners can fix a mild underbite in growing children aged 8 to 11. It compares how well the aligners move teeth and jaws compared to other treatments.
Al Mansurah, Dakahlia GovernorateAges 8–11 - NCT07466641Recruiting
Low-level laser or Piezocision to speed up canine tooth movement
This trial compares two treatments to see if they can safely speed up a specific tooth movement during braces. It tests a low-level laser or a minor surgical procedure called Piezocision against standard care.
Cairo, Cairo GovernorateAges 18–25 - NCT07405905Recruiting
Comparing mini implant placements for fixing upper teeth overbite
This study tests two ways of placing small temporary anchors (mini implants) in the jaw to help pull upper front teeth back into a better position. It is for patients who have finished growing and have a Class II overbite, to see which anchor location works best.
Rohtak, HaryanaAges 18–30 - NCT07376954Enrolling by invitationPhase 1
Bite correction for children with underbite
This trial tests a special dental device that is glued to the teeth to correct an underbite in children aged 8-11. It aims to improve the way the upper and lower jaws fit together.
Al MansurahAges 8–11 - NCT03513003Recruiting
Pacifier use to improve misaligned baby teeth
This study tests whether using a pacifier can help correct common misalignments in young children’s baby teeth and bite. It may help children whose upper and lower teeth don’t meet properly, with or without tongue thrust.
BaselAges 2–5 - NCT06984666Enrolling by invitation
Study of facial profiles at 45 degrees
This study looks at facial features from a 45-degree angle to see what makes a beautiful profile. It includes orthodontists, patients who have had braces for over a year, and adults without braces experience. You will have photos taken and answer some questions.
Fuzhou, FujianAges 18–50 - NCT05950581Recruiting
Twin-block braces with clear plates for jaw misalignment
This study tests a removable orthodontic device (twin-block with clear plates) to improve how the upper and lower jaws fit together in children. It may help if you have a specific “Class II” jaw pattern caused mainly by a lower jaw that sits back.
HamaAges 10–13 - NCT07868705Enrolling by invitation
Comparing small screws for braces in the upper jaw
This study compares two sizes of tiny screws (called miniscrews) that are sometimes used with braces to help move teeth. The screws are placed in the upper jaw to help correct an overbite where the top teeth stick out too far. The study looks at how well the screws work, how stable they are, and how they feel to patients.
Kuala LumpurAges 13–50 - NCT06409923RecruitingPhase 1
Comparing Herbst vs Invisalign for jaw alignment in teens
This trial compares two different braces (a Herbst appliance and Invisalign MA) to see which works better for teenagers whose upper jaw is too far forward. It's for kids who are still growing and have a specific type of overbite.
AnderlechtAges Up to 15 years - NCT07828041Recruiting
Jaw surgery and how it affects jaw joint movement
This study looks at how corrective jaw surgery changes how your jaw joint works. If you are planning to have jaw surgery to correct a severe bite or facial imbalance, this research may help doctors understand the effects on jaw movement.
BudapestAges 18 years+ - NCT07810699Recruiting
Laser or LED light for moving upper canine teeth
This study compares two types of light therapy, laser and LED, to see which one helps move your upper canine teeth faster and more comfortably during orthodontic treatment. It may help reduce treatment time and pain.
Can ThoAges 15–40 - NCT07752498Enrolling by invitation
Long-term results from twin block treatment
This study checks whether the results from an earlier treatment with the Twin Block appliance, which corrects bite problems, hold up over time. It looks at how stable the teeth and jaw remain years after treatment.
Jönköping, Jönköping CountyAges Any age - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
Kirikkale, KırıkkaleAges 18–40 - NCT06652230Recruiting
Comparing two ways to place braces for a better smile
This study compares two methods of placing braces to improve smile appearance. It tests if using the natural curve of your smile works better than a standard chart for bracket positioning.
Cairo, ManialAges 11–30 - NCT07692880Recruiting
Digital vs. conventional brace bonding for teens
This trial compares a new digital method for putting braces on teeth to the usual manual method. If you need braces on both top and bottom and have all your adult teeth, this study may help improve how comfortable and fast your treatment is.
FlorenceAges 12–18 - NCT06651944Recruiting
Invisalign with jaw advancement aligners
This trial tests Invisalign clear aligners that also help move the lower jaw forward. It may be a good fit if you need both teeth straightening and jaw positioning help.
Richmond, British ColumbiaAges 10–16 - NCT07676695Recruiting
Jaw Device and Sound Waves for Class II Malocclusion
This trial tests a special jaw repositioning device (Twin-Block) combined with low-intensity sound waves (LIPUS) to help treat a class II malocclusion (when the lower jaw is set back) in children and teens. It aims to improve jaw alignment and joint outcomes.
CairoAges 10 months–1.2 years
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Common questions
- Are there clinical trials for malocclusion?
- Yes. Clin2 currently lists 58 recruiting malocclusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malocclusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malocclusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.