Clinical trials
Cognition Improvement clinical trials
Below are recruiting cognition improvement clinical trials, each written for real people, not researchers. We’re tracking 110 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06668610Recruiting
Brain stimulation study for mild memory problems
This study tests a non-invasive brain stimulation technique (tDCS) combined with brain wave recording (EEG) to see if it can improve memory and thinking in people with mild cognitive impairment or early dementia.
Caserta, ItalyAges 55–85 - NCT05708001Recruiting
Testing brain stimulation to improve memory in mild impairment
This study tests whether a noninvasive brain stimulation method (tACS) can improve memory in people with mild cognitive impairment (MCI). A caregiver also helps with the stimulation during the study, and success is measured through study visits and memory-related evaluations.
GenevaAges 55–85 - NCT06906328Recruiting
ADHD and addiction: can cognitive training help?
This study tests whether adding a cognitive remediation program to methylphenidate (a medication for ADHD) improves treatment response in adults who have both ADHD and a substance use or behavioral addiction. It aims to help patients manage symptoms better over the short and medium term.
Brest, Brittany RegionAges 18–99 - NCT07419633Recruiting
Study on supplements to improve strength and thinking in older adults
This trial tests if two supplements, HMB and 2-HOBA, taken alone or together, can help improve muscle strength and mental function in healthy adults over 65. The goal is to see if these supplements can improve overall quality of life.
Montreal, QuebecAges 65 years+ - NCT05864274Recruiting
Cognitive training for people on chemotherapy
This trial studies a phone or tablet brain-training program to help with “cancer-related cognitive impairment,” or thinking and memory problems that can happen during chemotherapy. If you’re newly diagnosed with certain gynecologic cancers and are receiving chemotherapy, this may help you see whether the training improves cognitive symptoms.
Birmingham, AlabamaAges 18–90 - NCT06799481Recruiting
Home-based exercise to help brain tumor survivors with thinking and memory
This study tests whether a virtual home-based exercise program can improve thinking and memory problems caused by brain tumor treatment in teens and young adults. It also looks at how exercise affects gut health.
Atlanta, GeorgiaAges 15–39 - NCT06995638Recruiting
Multitasking training for older adults
This study tests whether a special online training program can help older adults improve their ability to multitask and stay focused. You'll do some computer exercises at home and come in for a few checkups, including a blood test.
Newark, New JerseyAges 60–75 - NCT06740747Recruiting
Brain stimulation for schizophrenia symptoms
This study tests a new type of brain stimulation (called intermittent theta-burst stimulation) to see if it helps with symptoms like lack of motivation or trouble thinking clearly in people with schizophrenia. You will also have an MRI scan to see how the brain changes.
Hanover, Lower SaxonyAges 18–65 - NCT07208916Recruiting
Can eating grapes boost strength and thinking in older women?
This study tests whether eating grapes daily can help improve muscle strength and memory in healthy women aged 65 and older. If you join, you will need to follow a special diet that limits certain foods and supplements.
Springfield, MassachusettsAges 65 years+ - NCT07299279Recruiting
Exercise for Brain Health in Parkinson's
This trial studies whether a physical activity program can improve brain health and thinking skills in people with Parkinson's disease who also have mild cognitive impairment. It is designed for those who are not already very active.
Roma, RomeAges 30–80 - NCT05282550RecruitingPhase 2
Trazodone trial to improve sleep in early Alzheimer’s
This study tests whether the sleep medicine trazodone can improve thinking and memory in people with early Alzheimer’s-related changes who also have sleep problems. If better sleep helps the brain, it may improve memory test results over time.
Baltimore, MarylandAges 55 years+ - NCT05770479Enrolling by invitation
Testing long-lasting cognitive training for older veterans
This study looks at whether a cognitive training program you’ve already completed can keep helping over time, and whether it can be improved with “booster” sessions. It may help older veterans maintain thinking and daily functioning skills after earlier training.
San Diego, CaliforniaAges 55 years+ - NCT06498011Recruiting
Training to improve arm and hand function after stroke
This study tests a new type of training that combines thinking, feeling, and moving to help improve arm and hand function after a stroke.
Toronto, OntarioAges 18 years+ - NCT05333250RecruitingPhase 1/Phase 2
Modafinil to reduce cancer-related fatigue
This trial tests whether modafinil can improve cancer-related fatigue in people with advanced cancer. It may help you feel more able to function day to day by reducing how “worn out” you feel.
Ottawa, OntarioAges 18 years+ - NCT06801171Recruiting
Boosting resilience for people with mild memory problems
This study tests a program that combines gentle activities (like meditation, yoga, or tai chi) to help people with mild memory problems feel stronger and more able to handle stress. It is for people aged 60 and older who have mild cognitive issues but are not in therapy or already doing similar practices.
NiceAges 60 years+ - NCT06466460Recruiting
Interactive bike for quality of life in memory loss
This study tests if using a special interactive stationary bike can improve quality of life for older adults with memory or thinking problems who live in nursing homes. You would be asked to pedal the bike a few times, and the program makes it fun and engaging.
ÖrebroAges 65 years+ - NCT05699226Recruiting
Testing whether adjusting ECT treatment helps depression outcomes
This study tests a way of adjusting (titrating) ECT treatment to improve outcomes in people with major depression or bipolar II. It’s mainly for those who already need ECT with right-side electrode placement.
Albuquerque, New MexicoAges 50 years+ - NCT06473987Recruiting
Virtual reality training for better walking after brain injury
This trial tests a virtual reality program that combines thinking and walking exercises to help improve your balance and walking speed. It may be a good fit if you have a traumatic brain injury and walk more slowly than usual.
West Orange, New JerseyAges 18–65 - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT06105307Enrolling by invitation
Improving sleep and fatigue for night shift RNs
This trial uses mobile technology and cognitive-behavioral techniques to help night shift nurses improve their sleep and reduce fatigue. If you work night shifts and have a smartphone, you may be eligible to join.
Cincinnati, OhioAges 18 years+ - NCT04229056Recruiting
Computer training to improve thinking and planning after stroke or Parkinson’s
This trial tests computer-based “self-training” to improve executive function, such as working memory—your ability to hold and use information in mind. It’s for adults with a prior stroke, cardiac arrest, or Parkinson’s disease who have trouble on a specific working-memory task.
CopenhagenAges 18–100 - NCT07379138Recruiting
Talk therapy for distress in advanced melanoma
This study is testing whether a type of talk therapy (cognitive behavioral therapy) can help improve quality of life, including mental health, for people recently diagnosed with advanced melanoma. It is designed to understand and reduce cancer-related distress.
Rochester, MinnesotaAges 18 years+ - NCT07239310Recruiting
Device to improve memory and thinking in early Alzheimer's
This study tests a device called Neuclare that aims to temporarily boost memory and thinking skills in people with mild cognitive impairment or very early Alzheimer's disease. It could offer a non-drug way to help with daily mental tasks.
Cheonan, Chungcheongnam-doAges 55–90 - NCT03574207Recruiting
Brain stimulation study for memory in certain adults
This study tests a targeted, non-surgical brain stimulation method to help people with memory, especially remembering facts over time. It compares healthy adults and adults with amnestic mild cognitive impairment (aMCI), using sessions plus brain scans and memory testing.
Omaha, NebraskaAges 19 years+
Hear when a new Cognition Improvement trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cognition improvement?
- Yes. Clin2 currently lists 110 recruiting cognition improvement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognition improvement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognition improvement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.