Clinical trials
Cognition clinical trials
Below are recruiting cognition clinical trials, each written for real people, not researchers. We’re tracking 1,981 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04153838Enrolling by invitation
Track thinking skills in children over time
This study follows children’s thinking and learning over time using simple testing at school. It aims to better estimate how children’s thinking develops and how it changes as they grow.
Aberdeen, UKAges 6–17 - NCT03948490Recruiting
Cognitive rehab and follow-up for lower grade brain tumors
This study offers cognitive rehabilitation and long-term monitoring for adults with lower grade gliomas. It aims to help improve thinking and memory problems you may be experiencing.
San Francisco, CaliforniaAges 18 years+ - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT03451383Recruiting
Study brain changes in older breast cancer patients
This study follows older women with newly diagnosed breast cancer to see who might develop thinking or memory problems over time. It may help researchers understand early brain risk and how treatment and other factors relate to cognitive decline.
Washington D.C., District of ColumbiaAges 60–105 - NCT03137095Recruiting
Study how chemotherapy affects brain function in breast cancer
This study looks at changes in thinking and brain function in people with early to locally advanced breast cancer before and during chemotherapy. You may also be offered a brain MRI in a separate optional part of the research to learn more about brain changes.
Rochester, New YorkAges 21 years+ - NCT02290834Recruiting
Studying brain and thinking changes after chemotherapy in older breast cancer patients
This study looks at how chemotherapy may affect memory and thinking, using thinking tests and possibly brain imaging. It compares older breast cancer patients who do and do not get chemotherapy, plus a group of healthy older adults.
Boston, MassachusettsAges 60 years+ - NCT07877376Recruiting
How thinking problems affect pain in breast cancer survivors
This study looks at whether mild memory or thinking issues after breast cancer treatment are linked to ongoing pain. If you join, you will help doctors understand this connection, which may lead to better pain care.
Boulogne-Billancourt, IDEAges 35–65 - NCT07878078RecruitingPhase 3
Art and support program for parents of children with cancer
This trial offers art workshops and cognitive support sessions to help parents cope while their child is undergoing cancer treatment. The goal is to reduce stress and improve emotional well-being.
Cairo, Cairo GovernorateAges 20–60 - NCT07721467RecruitingPhase 2
Cognitive training with psilocybin for brain flexibility
This study tests whether combining a brain-training program with a psychedelic drug called psilocybin can boost the brain's ability to change and adapt. It may help improve thinking and memory.
Baltimore, MarylandAges 65–120 - NCT03774420Recruiting
Study of memory and thinking changes after breast surgery
This trial looks at whether certain anesthesia medications and airway devices are linked to short-term memory or thinking problems after breast surgery. If you’re having breast surgery under general anesthesia, your care team may compare outcomes to learn how to reduce “post-op cognitive dysfunction.”
Treviso, TVAges 18 years+ - NCT07169630RecruitingPhase 1
PET scan study for Alzheimer's or mild cognitive impairment
This study uses a special PET scan to look at a brain protein called PDE4 in people with Alzheimer's disease or mild cognitive impairment. It may help researchers understand how this protein is involved in memory and thinking problems.
Bethesda, MarylandAges 50–100 - NCT06542458Enrolling by invitation
Cognitive health study for under-represented communities
This study looks at cognitive changes in people from communities that are often not well represented in research. It uses a telehealth approach to make participation easier and may help improve understanding of early memory and thinking problems.
Columbus, OhioAges 50 years+ - NCT07876570Recruiting
Predicting memory decline with brain and blood tests
This study follows older adults with normal memory, mild memory problems, or dementia over a year to see if brain scans and blood tests can predict who will get worse. It may help find early warning signs of Alzheimer's and other dementias.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07358598Recruiting
Eye movement and thinking in older adults
This study looks at how eye movements relate to thinking abilities in people aged 65 and older. It may help understand how the brain changes with age.
Kaohsiung CityAges 65 years+ - NCT04360200Recruiting
Study of thinking changes in older adults
This trial looks at people over age 50 who have mild thinking or memory problems but do not have dementia by standard clinical criteria. It tests how these early changes are characterized and measured using exams such as blood tests and brain scans, which may help improve understanding and future care.
Guangzhou, GuangdongAges 50 years+ - NCT05250349Recruiting
Ultrasound brain blood flow and thinking in stable heart failure
This trial studies whether a noninvasive ultrasound test of blood flow in the brain, along with memory and thinking questionnaires, can help explain thinking changes in people with stable heart failure. It may help researchers better understand why some people develop cognitive (thinking) difficulties as heart failure progresses.
Krakow, MPAges 18 years+ - NCT05357456Recruiting
Study of brain and memory changes in cortisol-producing adrenal conditions
This study tracks thinking and brain changes over time in people with adrenal findings that produce too much cortisol (a stress hormone) on their own. It may help doctors understand how different treatments or watchful waiting affect the brain and cognition.
Nanjing, JiangsuAges 20–65 - NCT05468905Recruiting
Study of aging and early thinking changes over time
This study follows adults 40+ to better understand and track changes in memory and thinking as people age. It groups people with normal thinking, subjective complaints, mild cognitive impairment, early Alzheimer’s, and vascular (blood vessel) related brain changes to find what predicts progression.
Hangzhou, ZhejiangAges 40–99 - NCT05555693Recruiting
Brain chemistry study after surgery in older adults
This study looks at how brain “metabolomics” (small chemical signals in the brain/body) relate to thinking or mood problems that can happen after surgery in people age 65 and older. It may help doctors understand who is more likely to have these side effects after an operation.
Shanghai, Shanghai MunicipalityAges 65 years+ - NCT05694039Recruiting
Track thinking changes in older adults with hearing loss
This study follows older adults who have age-related hearing loss to see whether wearing hearing aids helps protect thinking and memory over time. You may be included if your hearing loss is the type that hearing aids can usually improve and if your thinking test scores suggest mild cognitive difficulties.
Guangzhou, GuangdongAges 60–85 - NCT03542734Recruiting
Imaging study for thinking and brain changes in older adults
This study looks at brain scans and eye/eye-nerve findings to understand why thinking can change with aging. It may help researchers connect eye and brain changes, which could guide future ways to prevent or detect dementia early.
HangzhouAges 40 years+ - NCT05193136Recruiting
Testing sleep and exercise effects on strength and thinking in lung disease
This trial studies whether improving sleep habits can help people with lung conditions like COPD or IPF maintain muscle strength and thinking (cognitive function). It may help by addressing sleep quality and related health factors, but eligibility depends on your current diagnoses and treatments.
Jōyō, KyotoAges 20 years+ - NCT05294068Recruiting
Study barriers to physical activity in aging with disabilities
This study looks at what makes it hard or easier for people with cognitive, physical movement, or sensory (hearing/vision) impairments to be active as they age. It may help improve support and services for physical activity at a rehabilitation/parasport clinic.
GarchesAges 6 years+
Hear when a new Cognition trial opens
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Common questions
- Are there clinical trials for cognition?
- Yes. Clin2 currently lists 1,981 recruiting cognition studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognition trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.