Clinical trials · Massachusetts
Cognitive Impairment clinical trials in Massachusetts
We’re tracking 22 recruiting cognitive impairment studies with a site in Massachusetts — including Early Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT06687161Recruiting
Treating insomnia in mild memory problems
This study tests whether a non-invasive brain stimulation method (TMS) combined with cognitive training can improve sleep in older adults with mild memory issues. It may help if you have trouble falling or staying asleep and have early memory changes.
Boston, MassachusettsAges 60 years+ - NCT04916210Recruiting
Study how stroke type affects thinking and recovery
This study looks at what predicts memory and thinking problems after different types of stroke or brain bleeding, and how blood-vessel changes relate to recovery. You may be invited if you recently had a stroke/bleed and can complete a baseline check within 6 weeks.
Boston, MassachusettsAges 18 years+ - NCT06245031Enrolling by invitation
Long-term follow-up of sensory stimulation for Alzheimer's
This is a follow-up study for people who already completed the 12-month Hope Study (CA-0011). It tests long-term safety and effects of a gentle sensory stimulation device (light and sound) for Alzheimer's disease. You will continue using the device at home with a study partner.
Newton, MassachusettsAges 50–92 - NCT06792877Recruiting
Mindfulness for thinking in early Alzheimer's
This study tests if mindfulness training can help protect thinking and memory in early-stage Alzheimer's disease. It compares mindfulness to other activities to see if it slows down memory loss.
Boston, MassachusettsAges 50–100 - NCT05881239Recruiting
Remote smell tests to track early Alzheimer’s health changes
This trial uses remote, at-home (or remote) smell-based testing to help researchers assess health in people with preclinical Alzheimer’s disease and in control participants. It may help by showing how well smell-related changes can signal disease status over time.
Boston, MassachusettsAges 18–100 - NCT07236190RecruitingPhase 2
Using brain markers to test NPC-1 for Alzheimer's
This trial tests whether NPC-1, a new drug, can help people with early memory changes or Alzheimer's. Your blood or PET scan will show if you have Alzheimer's-related brain changes, which is required for this study.
Boston, MassachusettsAges 55 years+ - NCT06839079Recruiting
Brain training for trauma survivors with head injury
This study tests a cognitive rehabilitation program for people with traumatic brain injury who have also experienced war, violence, or other trauma. It aims to improve memory and thinking skills using exercises and strategies.
Boston, MassachusettsAges 18–65 - NCT02290834Recruiting
Studying brain and thinking changes after chemotherapy in older breast cancer patients
This study looks at how chemotherapy may affect memory and thinking, using thinking tests and possibly brain imaging. It compares older breast cancer patients who do and do not get chemotherapy, plus a group of healthy older adults.
Boston, MassachusettsAges 60 years+ - NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT06976216RecruitingPhase 3
Study of KarXT plus KarX-EC for Alzheimer's cognitive symptoms
This trial tests a new combination treatment (KarXT plus KarX-EC) to see if it can help with thinking and memory problems caused by Alzheimer's disease. It is for people with mild to moderate Alzheimer's who have a caregiver available.
Newton, MassachusettsAges 60–85 - NCT05617014Enrolling by invitation
ADNI4 study for early Alzheimer’s with brain imaging tests
This study enrolls people with no memory impairment, mild memory problems, or mild Alzheimer’s dementia to test how brain scans and cognitive tests relate to Alzheimer’s disease. It may help by contributing to better early diagnosis and by letting you see whether you fit into the study’s imaging and blood-test pathway.
Boston, MassachusettsAges 55–90 - NCT07659964Recruiting
Rhythmic music and walking study for Alzheimer's
This study tests whether listening to a steady beat (rhythmic music) while walking can improve movement and brain function in people with mild Alzheimer's disease. Healthy volunteers are also needed for comparison.
Boston, MassachusettsAges 50–90 - NCT05904132Recruiting
Brain stimulation therapy for early Alzheimer’s memory loss
This trial studies a “closed-loop” brain stimulation approach to improve symptoms in people with early Alzheimer’s-related memory problems. It may help by delivering stimulation based on your brain signals, if you meet the safety and diagnosis requirements.
Charlestown, MassachusettsAges 50–80 - NCT04124029Recruiting
Study how mild brain injuries may relate to dementia
This study looks at how past mild traumatic brain injury may contribute to brain changes seen in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease (AD). It may help researchers understand risk and brain markers by comparing people with mild or moderate TBI, people with mild memory problems, and healthy controls.
Boston, MassachusettsAges 30–90 - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Boston, MassachusettsAges 75 years+ - NCT06191965RecruitingPhase 2/Phase 3
MitoQ supplement for early psychosis
This study tests whether a supplement called MitoQ can help people with early-stage psychosis by improving how their cells produce energy. If you are younger and have been treated for psychosis for less than 5 years, this trial may be an option for you.
Belmont, MassachusettsAges 18–35 - NCT06489548RecruitingPhase 2
Foralumab for Early Alzheimer's Disease
This study tests an experimental drug called Foralumab, which aims to calm overactive immune cells in the brain linked to Alzheimer's. It may help slow memory loss in people with early-stage Alzheimer's.
Boston, MassachusettsAges 60–85 - NCT06502964RecruitingPhase 2
ALTO-101 study for schizophrenia cognitive symptoms
This study tests an experimental medication called ALTO-101 for people with schizophrenia who also have cognitive impairment (memory or thinking problems). It aims to see if the drug can improve these symptoms while you continue your current antipsychotic treatment.
Belmont, MassachusettsAges 21–55 - NCT06538311RecruitingEarly Phase 1
TMS treatment for early Alzheimer's disease
This study tests whether a non-invasive brain stimulation treatment called TMS (transcranial magnetic stimulation) can help people with early Alzheimer's disease or related memory problems. It's a safe, gentle way to stimulate brain cells using magnetic pulses.
Boston, MassachusettsAges 40–99 - NCT06976203RecruitingPhase 3
Testing karxt for thinking problems in alzheimer's
This trial tests if a combination medicine, KarXT plus KarX-EC, can help with thinking and memory problems in people with mild to moderate Alzheimer's disease. It aims to see if the treatment is safe and effective.
Watertown, MassachusettsAges 60–85 - NCT06989619Recruiting
Sleep and mindfulness program for older adults in residential housing
This study uses peer support and group activities to help older adults living in residential facilities improve their sleep and practice mindfulness (a type of focused relaxation). If you're 55+ and live in a residential building, you may be able to join.
Boston, MassachusettsAges 55 years+
Cognitive Impairment trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting cognitive impairment studies listed above.
- Massachusetts General Hospital · 8 studies
- VA Boston Healthcare System Jamaica Plain Campus · 3 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Boston Center for Memory · 2 studies
- Boston University · 2 studies
- Brigham and Women's Hospital · 2 studies
- McLean Hospital · 2 studies
- Boston Medical Center
What taking part in a cognitive impairment study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cognitive Impairment trials in other states
Common questions
- Are there cognitive impairment clinical trials in Massachusetts?
- Yes. We're currently tracking 22 recruiting cognitive impairment studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cognitive impairment study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cognitive impairment studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.