Clinical trials · California
Cognitive Impairment clinical trials in California
We’re tracking 37 recruiting cognitive impairment studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07474038Enrolling by invitation
AI-Supported Memory Training for Older Adults
This study tests a computer-based program that uses artificial intelligence (AI) to help older adults with mild memory problems improve their thinking skills. It is done remotely, so you can participate from home.
Pasadena, CaliforniaAges 65 years+ - NCT07220694Recruiting
Sabroxy supplement for memory and insulin resistance
This study tests whether a supplement called Sabroxy can improve insulin resistance and memory in adults with mild cognitive impairment and insulin resistance. It may help if you have early memory problems and your blood sugar is slightly higher than normal.
San Francisco, CaliforniaAges 40–80 - NCT05201534Recruiting
Math and thinking skills training for school-age children
This trial studies interventions to improve math and cognitive (thinking) skills in elementary school children. It includes both children with math learning difficulties and typically developing children, using tests and MRI brain scans for those who can participate.
Palo Alto, CaliforniaAges 6–12 - NCT06005038RecruitingPhase 1
Memory training study for older adults with mild cognitive issues
This study tests a computer-based memory training program to see if it can improve memory and thinking skills in older adults with mild cognitive impairment. It may help you if you have memory concerns but still live independently.
Palo Alto, CaliforniaAges 60 years+ - NCT06245031Enrolling by invitation
Long-term follow-up of sensory stimulation for Alzheimer's
This is a follow-up study for people who already completed the 12-month Hope Study (CA-0011). It tests long-term safety and effects of a gentle sensory stimulation device (light and sound) for Alzheimer's disease. You will continue using the device at home with a study partner.
Anaheim, CaliforniaAges 50–92 - NCT04916210Recruiting
Study how stroke type affects thinking and recovery
This study looks at what predicts memory and thinking problems after different types of stroke or brain bleeding, and how blood-vessel changes relate to recovery. You may be invited if you recently had a stroke/bleed and can complete a baseline check within 6 weeks.
Los Angeles, CaliforniaAges 18 years+ - NCT07866768Recruiting
Ultrasound treatment to clear brain waste in early memory loss
This study tests a low-intensity ultrasound treatment aimed at helping the brain clear out harmful protein buildup linked to Alzheimer's disease. It is for people 65 and older with mild cognitive impairment (slight but noticeable memory problems) and a positive test for amyloid, a protein in the brain.
San Francisco, CaliforniaAges 65 years+ - NCT07191483RecruitingPhase 2
Study of KYN-5356 for cognitive problems in schizophrenia
This trial tests an investigational drug, KYN-5356, to see if it can improve thinking and memory problems in adults with schizophrenia. You may join if your schizophrenia is stable and you take only one antipsychotic medication.
Cerritos, CaliforniaAges 18–55 - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT07130669RecruitingPhase 1/Phase 2
Memory and thinking study for older adults
This trial tests a program to help maintain or improve memory and thinking skills in older adults. You may join if you are 60-89, speak English, and live at home or in an assisted-living facility.
Palo Alto, CaliforniaAges 60–89 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT04520139RecruitingPhase 1/Phase 2
NAC to help prevent chemo brain fog in ovarian cancer
This Phase 1/2 study tests whether taking NAC (a supplement medicine) can help prevent or reduce memory and thinking problems after platinum chemotherapy. It targets people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are starting at least six cycles of platinum-based treatment.
Orange, CaliforniaAges 18 years+ - NCT06413173Recruiting
Remote brain stimulation for attention after mild TBI
This trial tests if a remote brain stimulation device can improve attention and concentration in active-duty service members who have had a mild traumatic brain injury. Participants use the device at home while completing tasks to help with daily focus.
San Diego, CaliforniaAges 18–60 - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT04240665Enrolling by invitation
Test a digital notebook for memory problems
This study tests a digital “memory notebook” to help people who have early memory concerns keep track and report changes over time. It may be useful if you’re having mild memory issues and can complete surveys with a study partner.
Sacramento, CaliforniaAges 60 years+ - NCT05770479Enrolling by invitation
Testing long-lasting cognitive training for older veterans
This study looks at whether a cognitive training program you’ve already completed can keep helping over time, and whether it can be improved with “booster” sessions. It may help older veterans maintain thinking and daily functioning skills after earlier training.
San Diego, CaliforniaAges 55 years+ - NCT06107842Recruiting
Exercise program for older veterans' memory and thinking
This study tests whether an exercise program called Gerofit can help improve memory and thinking in older Veterans. If you join, you will take part in supervised exercise sessions to see how it affects your brain health.
West Los Angeles, CaliforniaAges 65 years+ - NCT07646054Enrolling by invitation
Lifestyle coaching for preventing Alzheimer's in APOE4 carriers
This study tests a digital lifestyle coaching program designed to help prevent Alzheimer's disease in people who carry the APOE4 genetic variant, which increases risk. Over one year, you'll get personalized health coaching through apps and possibly a smart ring to track your progress.
La Jolla, CaliforniaAges 60–80 - NCT07516119Recruiting
Predicting Alzheimer's Risk Before Memory Loss Occurs
This study identifies people at high risk for Alzheimer's disease before symptoms develop, using genetics and digital tools to track brain health over time. If you qualify, you'll help researchers understand who will develop cognitive decline and potentially enable earlier interventions.
San Diego, CaliforniaAges 55 years+ - NCT05980117RecruitingPhase 4
Remimazolam sedation for cataract surgery
This study tests a sedative, remimazolam, for older adults having their first cataract surgery. It aims to see if it helps keep patients comfortable and calm without needing general anesthesia.
Los Angeles, CaliforniaAges 65 years+ - NCT06976203RecruitingPhase 3
Testing karxt for thinking problems in alzheimer's
This trial tests if a combination medicine, KarXT plus KarX-EC, can help with thinking and memory problems in people with mild to moderate Alzheimer's disease. It aims to see if the treatment is safe and effective.
Fullerton, CaliforniaAges 60–85 - NCT06976216RecruitingPhase 3
Study of KarXT plus KarX-EC for Alzheimer's cognitive symptoms
This trial tests a new combination treatment (KarXT plus KarX-EC) to see if it can help with thinking and memory problems caused by Alzheimer's disease. It is for people with mild to moderate Alzheimer's who have a caregiver available.
Long Beach, CaliforniaAges 60–85
Cognitive Impairment trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting cognitive impairment studies listed above.
- Neurology Center of North Orange County · 2 studies
- Stanford Neuroscience Health Center · 2 studies
- University of California, Irvine · 2 studies
- University of California, San Francisco · 2 studies
- Advanced Research Center, Inc
- Alzheimer's Disease Center, University of California, Davis
- Anderson Clinical Research
- ATP Clinical Research, Inc.
What taking part in a cognitive impairment study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cognitive Impairment trials in other states
Common questions
- Are there cognitive impairment clinical trials in California?
- Yes. We're currently tracking 37 recruiting cognitive impairment studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cognitive impairment study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cognitive impairment studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.