Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,580 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04342546Recruiting
Radiation skin side-effect test after mastectomy with implant
This trial looks at a test meant to predict how likely you are to develop side effects from radiation to the chest wall after mastectomy. It is designed for people getting immediate breast reconstruction using an implant, so treatment planning may be safer and more personalized.
DijonAges 18 years+ - NCT04341181RecruitingPhase 2
Targeted cancer treatment chosen by tumor genetic test results
This Phase 2 trial matches people with advanced cancer to a targeted treatment based on a genetic (DNA) or protein (IHC) test from their tumor. It’s for cancers that are no longer responding to standard treatment or where no standard option is available.
Aalborg, AalborgAges 18 years+ - NCT04344496Recruiting
Collecting breast cancer tissue to predict recurrence risk
This study builds a “genome atlas” to better predict the chance that breast cancer will come back. It asks participants to share medical information and provide blood and tumor tissue samples, including samples kept in paraffin.
TaipeiAges 20 years+ - NCT04375904RecruitingPhase 2
Stereotactic radiation for central lung tumors
This trial tests a precise, high-dose radiation treatment aimed at central lung tumors. It may help people who cannot have lung surgery and whose tumors can be safely targeted near sensitive organs.
DublinAges 18 years+ - NCT04402151RecruitingPhase 2
PSMA scan–guided targeted radiation for higher-risk prostate cancer
This trial uses a special PET/MR scan to help doctors aim stereotactic radiation more precisely for certain higher-risk or unfavorable intermediate prostate cancers. It studies whether this targeted approach can safely treat the prostate (and specific areas needing extra treatment) without spreading to the body.
New York, New YorkAges 21–90 - NCT04455282Recruiting
Blood test-guided surgery for gastroesophageal cancer
This trial studies blood-based biomarkers to help doctors choose the best individualized surgical treatment for gastroesophageal junction adenocarcinoma. If you qualify, you’ll get standard care plus additional testing to see whether the blood results can guide surgery more precisely.
Cologne, North Rhine-WestphaliaAges 18 years+ - NCT04481763RecruitingPhase 1/Phase 2
Camrelizumab plus radiation for early triple-negative breast cancer
This trial studies whether adding camrelizumab (an immunotherapy drug) to radiation can improve outcomes and be safe for people with early triple-negative breast cancer. It is designed for specific early-stage cases after breast surgery, using tumor and blood tests to match the cancer’s features.
Nanchang, JiangxiAges 18–75 - NCT04498221Recruiting
Mapping lymph flow in oropharyngeal cancer with scans
This study uses a special dye or tracer to map how lymph fluid travels from an oropharyngeal (throat) cancer to nearby lymph nodes. It may help doctors understand the most likely spread pattern and plan future treatment more accurately.
LondonAges 18 years+ - NCT04525989Recruiting
Short-course proton vs photon radiation before rectal surgery
This study compares two types of pre-surgery radiation—protons versus standard photons—in people with high-risk rectal cancer. The goal is to shrink and control the tumor while safely getting you ready for surgery, and to see which approach works better.
Stockholm, SolnaAges 18 years+ - NCT04539977RecruitingPhase 2
PD-L1 antibody plus chemotherapy for limited-stage small-cell lung cancer
This Phase 2 study tests whether adding a PD-L1 antibody to chemotherapy helps people with newly diagnosed limited-stage small-cell lung cancer live longer and control the cancer better. It may benefit patients who have not had any prior cancer treatment for SCLC and can meet health and lab requirements.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04574960RecruitingPhase 3
Neoadjuvant chemotherapy before kidney/ureter cancer surgery
This Phase 3 trial studies giving cisplatin-based chemotherapy before surgery for certain newly diagnosed upper-urinary-tract urothelial cancers (kidney/ureter). It may help shrink the cancer and improve outcomes by treating microscopic disease earlier.
Ottawa, OntarioAges 18 years+ - NCT04616131Recruiting
Testing ctDNA as a marker in pancreatic cancer treatment
This trial is studying a blood test that looks for tumor DNA (ctDNA) to see if it can help predict how well treatment is working in people with pancreatic cancer that hasn't spread. It is for patients getting chemotherapy before possible surgery.
DeKalb, IllinoisAges 18 years+ - NCT04620187RecruitingPhase 2
Study medicine T-DM1 after surgery for HER2-positive salivary cancer
This Phase 2 trial studies T-DM1 given after surgery for salivary gland cancer that is HER2-positive. The goal is to reduce the risk of the cancer coming back by targeting HER2-positive tumor cells.
Atlanta, GeorgiaAges 18 years+ - NCT04643041Recruiting
Watch-and-wait after PD-1 for certain rectal cancer
This study looks at whether people with a very strong response to a PD-1 antibody can safely delay or avoid more standard rectal cancer treatment (a “watch-and-wait” approach). It may help some people avoid surgery, radiation, or ongoing treatment while still closely monitoring the cancer.
Guangzhou, GuangdongAges 18–80 - NCT04657042Recruiting
4D MRI scans to guide lung or liver cancer radiation
This trial tests whether special “4D” MRI scans can improve precision radiation planning for people with lung or liver cancer. You may get MRI scan data to better account for tumor movement, alongside your usual radiation treatment.
Charlottesville, VirginiaAges 18–82 - NCT04683653RecruitingPhase 1/Phase 2
Pelvic radiation test for uterine or cervical cancer
This trial studies a specific radiation schedule aimed at the pelvis (lower belly area) for uterine or cervical cancer. It looks at whether this “hypofractionated” approach can control cancer while limiting side effects, especially in patients whose disease has not spread to distant organs.
Atlanta, GeorgiaAges 18 years+ - NCT04696081Recruiting
Atrial fibrillation treatment in people with active cancer
This trial studies atrial fibrillation (an irregular heartbeat) in adults who have active cancer. It looks at people whose atrial fibrillation started after their cancer diagnosis or returned after cancer diagnosis.
Caen, NormandyAges 18 years+ - NCT04728724RecruitingPhase 2
Check immune treatment before surgery for stage III lung cancer
This Phase 2 trial tests an “immunotherapy” medicine given before surgery for stage III non-small cell lung cancer. The goal is to shrink the cancer and make curative surgery more successful while monitoring safety and response.
ShanghaiAges 18–75 - NCT04729543RecruitingPhase 1/Phase 2
TCR cell therapy for melanoma and head and neck cancer
This early-phase study tests a lab-made T-cell treatment that targets a specific tumor marker (MC2) in melanoma and head and neck cancers. It aims to see if the treatment can safely shrink tumors and control cancer after standard options have run out.
RotterdamAges 18 years+ - NCT04787354RecruitingPhase 3
Choosing the best length of oxaliplatin after stomach surgery
This trial tests whether giving oxaliplatin for a shorter or longer time works best after curative surgery for stage II–III stomach (or stomach–esophagus junction) cancer. It aims to improve outcomes while balancing side effects from chemotherapy.
Gyeonggi-doAges 19 years+ - NCT04842162RecruitingPhase 2
Near-infrared dye imaging to help remove all mouth/throat cancer
This Phase 2 study tests a special camera and dye during surgery to help surgeons confirm they removed all cancer at the edge of the removed tissue. If it works, it may lower the chance of cancer being left behind after oral cavity or oropharynx squamous cell cancer surgery.
AnderlechtAges 18 years+ - NCT04843865Recruiting
Chinese herbal add-on for joint pain from letrozole
This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.
Bukit Bintang, Kuala LumpurAges 18 years+ - NCT04846309RecruitingPhase 1
MRI scan to personalize radiation for esophageal cancer
This Phase 1 study uses specialized imaging (including MRI) to better “see” low-oxygen areas in esophageal cancer and help guide individualized radiation treatment. It aims to improve how radiation is planned and delivered while checking safety.
Salt Lake City, UtahAges 18 years+ - NCT04852887RecruitingPhase 3
Testing shorter breast radiation after low-risk hormone breast cancer
This Phase 3 trial studies whether “less intense” radiation can work as well as standard radiation for certain early-stage hormone receptor–positive, HER2-negative breast cancers that have a low Oncotype DX score. It may help reduce treatment burden while keeping cancer control strong.
Birmingham, AlabamaAges 50–70
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,580 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.