Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,065 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06889844Recruiting
Blood test for colorectal cancer cross-reactivity study
This research study uses a blood test to look for signs of colorectal cancer in people who have other types of cancer or digestive diseases. The goal is to see if the test can correctly tell the difference between colorectal cancer and other conditions.
Málaga, AndalusiaAges 18 years+ - NCT06887218RecruitingPhase 2
Testing a new combination for advanced colorectal cancer
This trial tests a combination of two drugs, regorafenib and 5-FU with leucovorin, for people with colorectal cancer that has spread and has not responded to at least two previous treatments. The goal is to see if this new mix can help shrink or control the cancer.
Houston, TexasAges 18 years+ - NCT06869096Recruiting
Flushing liquid during colorectal cancer surgery
This trial compares two different liquids used to flush the surgical area during colorectal cancer surgery to see which one better prevents infections. If you are having surgery for colorectal cancer, you may be able to join.
Nanchong, SichuanAges 18–85 - NCT06856187RecruitingPhase 2
Second-line chemo plus TAS-102 combo for advanced colorectal cancer
This trial tests adding a new drug combo (TAS-102 and bevacizumab) to standard second-line treatment for advanced colorectal cancer, followed by local treatments. It may help if your first treatment stopped working and you are otherwise in good health.
Shanghai, Shanghai MunicipalityAges Any age - NCT06792695RecruitingPhase 2
Study of new treatments for colorectal cancer
This trial tests new treatment combinations for colorectal cancer that has spread (metastatic). It is for people whose cancer is mismatch repair proficient (pMMR) or microsatellite stable (MSS) and who have not had previous treatment for metastatic disease.
Scottsdale, ArizonaAges 18–130 - NCT06787105Recruiting
Fruquintinib for advanced colorectal cancer
This trial tests a drug called fruquintinib for people with advanced colorectal cancer that has spread. It is for patients who have already tried several standard treatments and need a new option.
Biberach, Baden-WurttembergAges 18 years+ - NCT06769087Enrolling by invitation
Removing urinary catheter right after colorectal cancer surgery
This study compares taking out the urinary catheter immediately after colorectal cancer surgery versus leaving it in for one day. It aims to see which approach leads to fewer complications and faster recovery.
Seoul, SeoulAges 19–80 - NCT06733038RecruitingPhase 3
Chemo plus Avastin with or without Tecentriq for advanced colorectal cancer
This trial tests whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (FOLFOXIRI) and bevacizumab (Avastin) is more effective as a first treatment for people with a specific type of metastatic colorectal cancer that has a high immune score and is mismatch repair proficient.
Brescia, BSAges 18–75 - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06738173Recruiting
Gut bacteria test to screen for colorectal cancer
This trial tests a new tool that looks at gut bacteria to help find colorectal cancer earlier. It's for people who already had a positive result on a standard stool test (FIT) as part of a national screening program.
Rome, RMAges 50–74 - NCT06717295Recruiting
Blood test to find cancer early and track treatment
This study uses a blood test that looks at your platelets and immune cells to find common cancers early, and for certain cancers, to monitor how well treatment is working.
RosarioAges 40–75 - NCT06714318Recruiting
Using blood samples to improve colorectal cancer screening
This study is looking at whether adding a blood test can make the current stool-based screening for colorectal cancer more accurate. It may help find cancers earlier or reduce the need for colonoscopy.
AabenraaAges 50–74 - NCT06298916RecruitingPhase 1/Phase 2
Study of 64Cu-LNTH-1363S in Sarcoma or GI Cancer
This trial tests a new imaging agent, 64Cu-LNTH-1363S, to see if it can find certain sarcomas and gastrointestinal cancers. The goal is to help doctors better see where your cancer is and plan the best treatment. You may be eligible if you have a sarcoma or a GI cancer and are willing to have a tumor tissue sample taken.
Duarte, CaliforniaAges 15 years+ - NCT06654037RecruitingPhase 1
Testing abemaciclib plus 5-FU for advanced colorectal cancer
This trial is testing whether adding a targeted drug called abemaciclib to the standard chemotherapy 5-FU can help people with a specific type of advanced colorectal cancer (MSS) that has stopped responding to other treatments. The goal is to see if this combination is safe and effective.
Irvine, CaliforniaAges 18 years+ - NCT06634875RecruitingPhase 2
Test of isunakinra alone or with pembrolizumab for colorectal cancer
This trial tests a new drug combination (isunakinra plus pembrolizumab) for people with a specific type of colorectal cancer (MSS, RAS-mutated) that has a high tumor mutational burden. It may help if other treatments have stopped working.
Los Angeles, CaliforniaAges 18 years+ - NCT06597955Enrolling by invitation
Colorectal Cancer Screening Decision Aid Study
This study is testing a tool to help people decide about getting screened for colorectal cancer. If you are between 45 and 75, get care at certain health systems (like IU Health), and are due for screening, you may be able to join.
Indianapolis, IndianaAges 18 years+ - NCT06565052Recruiting
Exercise and nutrition before rectal cancer surgery study
This trial tests whether a personalized exercise and nutrition program before rectal cancer surgery can help you recover faster and have fewer complications. If you are not very active right now, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT06559059Recruiting
Virtual cancer program for Veterans with new cancer
This study looks at how well a virtual (telemedicine) cancer program works for Veterans who are newly diagnosed with lung, prostate, breast, or colon cancer. Participation involves a telemedicine visit at a VA medical center instead of traveling to the hospital.
Brooklyn, New YorkAges 18 years+ - NCT06497985RecruitingPhase 3
New drug combo for advanced colorectal cancer
This trial tests a combination of three drugs—tucidinostat, sintilimab, and bevacizumab—for people with a specific type of advanced colorectal cancer (MSS or pMMR) that has gotten worse after standard treatments. The goal is to see if this new mix can help shrink or slow the tumor.
Guangzhou, GuangdongAges 18–75 - NCT06502275Recruiting
Nutrition and Exercise for Older Colorectal Cancer Patients
This trial tests a nutrition and exercise program designed for older adults with colorectal cancer. It uses a smartphone app to help you stay active and eat well at home.
Chiayi CityAges 60 years+ - NCT06401174Enrolling by invitation
Patient navigation for colorectal cancer screening
This study tests a patient navigation program to help people who are due for colorectal cancer screening get the test they need. It connects you with a guide to make scheduling and completing screening easier.
Washington D.C., District of ColumbiaAges 45–75 - NCT06184594Enrolling by invitation
Using eNav Toolkit to boost colon cancer screening
This trial tests a computer program (eNav Toolkit) to help people decide about colon cancer screening. If you are between 45 and 75 and due for screening, this study may help you make an informed choice.
New York, New YorkAges 45–75 - NCT06085560Enrolling by invitation
Choose and use an at-home colorectal cancer screening test
This study helps African American adults choose an at-home colorectal cancer screening test and make a plan to use it. It aims to make screening easier and more convenient for you.
Flint, MichiganAges 45–72 - NCT06101277Recruiting
Local therapy for limited new cancer growth in digestive cancers
This trial tests a cancer treatment that uses local therapies (like radiation or targeted heat) to destroy a small number of growing spots. It is for people with certain gastrointestinal cancers whose main treatment is working well except for a few new spots, so they can avoid switching to a different drug right away.
Sacramento, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,065 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.