Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,064 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06243393RecruitingPhase 2/Phase 3
Sacituzumab govitecan for advanced colorectal cancer
This study tests a drug called sacituzumab govitecan for people with metastatic colorectal cancer who have already tried several standard treatments. It may be an option if your cancer is not MSI-H or dMMR and you haven't had irinotecan recently.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06242067RecruitingPhase 2
Second-line treatment for advanced colorectal cancer
This trial tests a new treatment for people with advanced colorectal cancer that has spread or come back after initial chemotherapy. It is for those who have already received standard first-line therapy and are now looking for a second treatment option.
Jinan, ShandongAges 18–75 - NCT06236373Recruiting
Understanding cancer survivors' needs in Reggio Emilia
This study aims to understand the challenges and needs of people who have survived certain cancers (breast, prostate, thyroid, colorectal, multiple myeloma, or lymphoma) and their caregivers. It uses interviews or focus groups to gather perspectives.
Reggio Emilia, Reggio EmiliaAges 18 years+ - NCT06184594Enrolling by invitation
Using eNav Toolkit to boost colon cancer screening
This trial tests a computer program (eNav Toolkit) to help people decide about colon cancer screening. If you are between 45 and 75 and due for screening, this study may help you make an informed choice.
New York, New YorkAges 45–75 - NCT06118762RecruitingPhase 4
Study of fruquintinib plus raltitrexed for advanced colorectal cancer
This trial tests two drugs, fruquintinib and raltitrexed, for people with metastatic colorectal cancer that has stopped responding to or is no longer tolerable after standard treatments like fluorouracil, oxaliplatin, and irinotecan. The goal is to see if this combination can help shrink or control the cancer.
Nanchang, JiangxiAges 18 years+ - NCT06101277Recruiting
Local therapy for limited new cancer growth in digestive cancers
This trial tests a cancer treatment that uses local therapies (like radiation or targeted heat) to destroy a small number of growing spots. It is for people with certain gastrointestinal cancers whose main treatment is working well except for a few new spots, so they can avoid switching to a different drug right away.
Sacramento, CaliforniaAges 18 years+ - NCT06085560Enrolling by invitation
Choose and use an at-home colorectal cancer screening test
This study helps African American adults choose an at-home colorectal cancer screening test and make a plan to use it. It aims to make screening easier and more convenient for you.
Flint, MichiganAges 45–72 - NCT05959356RecruitingPhase 2
First-line treatment for left-sided metastatic colon cancer with specific tumor markers
This Phase 2 trial tests a combination of medicines (cetuximab, envafolimab, and chemotherapy) as the first treatment for certain left-sided metastatic colorectal cancers. It may help by slowing or shrinking the cancer in people whose tumor has no RAS/BRAF mutations and is microsatellite-stable (MSS).
Foshan, GuangdongAges 18 years+ - NCT05797467RecruitingPhase 3
After-surgery chemo plus targeted therapy for colon cancer
This Phase 3 trial studies whether adding targeted therapy to standard chemotherapy after surgery helps people with stage T3-4, N2 colon cancer live longer or have fewer cancer returns. You would be assigned to receive chemotherapy with targeted therapy or chemotherapy alone, based on the study plan.
Guangzhou, GuangdongAges 18–75 - NCT05780684Recruiting
Personalized 5-FU dosing for advanced gastrointestinal cancer
This study tests whether doctors can safely find the best dose of 5-FU, a chemotherapy medicine, for people with advanced gastrointestinal cancers. The goal is to reduce side effects while still treating the cancer effectively.
Lebanon, New HampshireAges 18 years+ - NCT05740956RecruitingPhase 1
Drug study for cancers with HRR gene or HRD changes
This Phase 1 study tests HS-10502 in people with advanced solid tumors that have certain DNA repair problems (HRR or HRD). It may help by finding a safe dose and seeing whether the drug can shrink tumors in cancers that have specific genetic features.
Beijing, Beijing MunicipalityAges 18–75 - NCT05725200RecruitingPhase 2
Personalized treatment plan for metastatic colon or rectal cancer
This Phase 2 trial tests an individualized treatment chosen from your tumor’s lab testing (genetic and RNA profile plus a drug-sensitivity test from your tumor cells). It may help by matching you to targeted anti-cancer drugs that are most likely to work for your specific cancer.
OsloAges 18 years+ - NCT05645510Recruiting
Study for people on long-term cancer targeted medicines
This study looks at people who are already taking long-term targeted cancer medicines. It may help researchers understand how these treatments work over time and whether there are ways to improve care.
Edmonton, AlbertaAges 18–90 - NCT05639413Recruiting
Study of biology in people with BRAF V600E metastatic colon cancer
This study follows people with BRAF V600E–positive metastatic colorectal (colon) cancer to better understand how the cancer’s biology changes over time. It may help researchers learn which features to watch and how this cancer behaves after initial treatment.
AvignonAges 18 years+ - NCT05517811Recruiting
Blood clotting tests before and after surgery for cancer
This study looks at how cancer and surgery affect blood clotting. It may help doctors understand and prevent blood clots in patients having surgery for certain cancers.
Aurora, ColoradoAges 18–99 - NCT05102110Recruiting
Check rectal mucus in people with throat or lung cancers
This study looks at a substance called rectal mucus during an exam to learn about changes in people with cancers of the throat/airways (aero-digestive tract). It’s a feasibility study, meaning it mainly tests whether this approach is safe and practical.
ExeterAges 18–99 - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99 - NCT04899908RecruitingPhase 2
Brain radiation with or without gadolinium nanoparticles for brain metastases
This trial tests whether adding tiny gadolinium-containing nanoparticles to standard brain radiation can better control brain metastases from certain cancers. It is for people with tumors that have grown after immunotherapy, are from certain cancers (like melanoma, GI, or HER2+ breast), are cystic, are large, or have come back after prior radiation.
Boston, MassachusettsAges 18 years+ - NCT05691491RecruitingPhase 1/Phase 2
Temozolomide plus M1774 for advanced metastatic cancers
This Phase 1/2 trial tests a combination of temozolomide and M1774 to see how safe it is and whether it can help shrink advanced cancers that have spread. It focuses on certain tumor types and specific biomarker results, and it may be an option if standard treatments have been tried or aren’t possible.
Irvine, CaliforniaAges 18 years+ - NCT00722228RecruitingPhase 1/Phase 2
Cancer vaccine made from your cells or a donor
This early-phase trial tests a whole-cell cancer vaccine for people with certain metastatic cancers. It aims to help your immune system recognize and fight the cancer, especially when prior chemotherapy hasn’t worked.
JerusalemAges 18 years+ - NCT07227636RecruitingPhase 2
Immunotherapy for ctDNA-positive colorectal cancer after surgery
This trial tests two immunotherapy drugs, botensilimab and balstilimab, for people with colorectal cancer who have had surgery and chemotherapy but still have detectable cancer DNA in their blood. The goal is to see if these drugs can help clear the remaining cancer cells.
Basking Ridge, New JerseyAges 18 years+ - NCT06568679Recruiting
Improving detection and treatment of early-onset colorectal cancer
This study aims to find better ways to detect and treat colorectal cancer in younger adults (ages 18–49). It includes people with both early-stage and advanced cancer.
Amsterdam, North HollandAges 18–49 - NCT06500052RecruitingPhase 1
Study of BL-M17D1 for HER2-positive or low-expression digestive tract and other solid tumors
This trial tests a new drug called BL-M17D1 for people with advanced or metastatic HER2-positive or low-expression gastrointestinal cancer and other solid tumors. The goal is to see if it is safe and effective.
Guangzhou, GuangdongAges 18–75 - NCT06307249RecruitingPhase 1
Precision therapy for solid tumors targeting CDK4/6 and VEGF
This trial tests a combination of two targeted drugs for advanced solid tumors like colorectal, lung, breast, and genitourinary cancers. The goal is to see if blocking certain proteins and a long RNA molecule can slow tumor growth.
Tripoli, North LebanonAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,064 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.